Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality

Mutations in endoglin or activin like kinase-1, both involved in the endothelial transforming growth factor-beta signaling pathway, cause the autosomal dominant bleeding disorder hereditary hemorrhagic telangiectasia. We and others have reported mouse models for this disease that share the character...

Ausführliche Beschreibung