Pathogenicity of three isolates of porcine respiratory coronavirus in the USA
The pathogenicity of three isolates of porcine respiratory coronavirus (AR310, LEPP and 1894) from the USA was assessed in specific pathogen-free pigs. Pigs inoculated with 1894 developed mild respiratory disease and pigs inoculated with AR31o and LEPP developed moderate respiratory disease from fou...
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| Veröffentlicht in: | Veterinary record 2003-03, Vol.152 (12), p.358-361 |
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| container_title | Veterinary record |
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| creator | Halbur, P. G. Pallarés, F. J. Opriessnig, T. Vaughn, E. M. Paul, P. S. |
| description | The pathogenicity of three isolates of porcine respiratory coronavirus (AR310, LEPP and 1894) from the USA was assessed in specific pathogen-free pigs. Pigs inoculated with 1894 developed mild respiratory disease and pigs inoculated with AR31o and LEPP developed moderate respiratory disease from four to 10 days after they were inoculated, but all the pigs recovered fully by 14 days after inoculation. Gross and microscopic examination revealed mild (1894) to moderate (AR31o and LEPP) multifocal bronchointerstitial pneumonia from four to 10 days after inoculation. The lesions were characterised by necrotising bronchiolitis, septal infiltration with mononuclear cells, and a mixed alveolar exudate. No clinical signs or microscopic lesions were observed in control pigs that had not been inoculated. |
| doi_str_mv | 10.1136/vr.152.12.358 |
| format | Article |
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G. ; Pallarés, F. J. ; Opriessnig, T. ; Vaughn, E. M. ; Paul, P. S.</creator><creatorcontrib>Halbur, P. G. ; Pallarés, F. J. ; Opriessnig, T. ; Vaughn, E. M. ; Paul, P. S.</creatorcontrib><description>The pathogenicity of three isolates of porcine respiratory coronavirus (AR310, LEPP and 1894) from the USA was assessed in specific pathogen-free pigs. Pigs inoculated with 1894 developed mild respiratory disease and pigs inoculated with AR31o and LEPP developed moderate respiratory disease from four to 10 days after they were inoculated, but all the pigs recovered fully by 14 days after inoculation. Gross and microscopic examination revealed mild (1894) to moderate (AR31o and LEPP) multifocal bronchointerstitial pneumonia from four to 10 days after inoculation. The lesions were characterised by necrotising bronchiolitis, septal infiltration with mononuclear cells, and a mixed alveolar exudate. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Coronaviridae Infections - microbiology Coronaviridae Infections - pathology Coronaviridae Infections - veterinary Coronavirus - classification Coronavirus - isolation & purification Coronavirus - pathogenicity Pneumonia, Viral - microbiology Pneumonia, Viral - pathology Pneumonia, Viral - veterinary Specific Pathogen-Free Organisms Swine Swine Diseases - microbiology Swine Diseases - pathology |
| title | Pathogenicity of three isolates of porcine respiratory coronavirus in the USA |
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