Iterative Oxazole Assembly via α-Chloroglycinates: Total Synthesis of (−)-Muscoride A

An efficient iterative synthesis of oxazoles involves the cyclization of 2‐alkynyl glycinates (see scheme) formed from the reaction of 1‐alkynyl aluminum reagents with α‐chloroglycinates. This approach was used in the total synthesis of the bisoxazole natural product, (−)‐muscoride A.