Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes
Podocyte structural changes have been suggested to be involved in the pathogenesis of albuminuria in diabetes. We evaluated podocytes density, number, and structure in 67 white patients with type 2 diabetes: 21 normoalbuminuric (NA), 23 microalbuminuric (MA), and 23 proteinuric (P). Kidney function...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2003-04, Vol.52 (4), p.1031-1035 |
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| container_title | Diabetes (New York, N.Y.) |
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| creator | DALLA VESTRA, Michele MASIERO, Alessandra ROITER, Anna Maria SALLER, Alois CREPALDI, Gaetano FIORETTO, Paola |
| description | Podocyte structural changes have been suggested to be involved in the pathogenesis of albuminuria in diabetes. We evaluated podocytes density, number, and structure in 67 white patients with type 2 diabetes: 21 normoalbuminuric (NA), 23 microalbuminuric (MA), and 23 proteinuric (P). Kidney function and biopsy studies were performed; 20 kidney donors served as control subjects. Electron microscopic morphometric analysis was used to estimate numerical density of podocytes per glomerulus [Nv(epi/glom)], filtration slit length density per glomerulus (FSLv/glom), and foot process width (FPW). The number of podocytes per glomerulus (Epi N/glom) was obtained by multiplying Nv(epi/glom) by mean glomerular volume. Nv(epi/glom) was significantly decreased in all type 2 diabetic groups compared with control subjects and was lower in MA and P than in NA (P < 0.0001, ANOVA). Epi N/glom was lower in MA and P patients compared with control subjects (P < 0.002, ANOVA); however, there were no significant differences among the type 2 diabetic groups. In addition, MA and P had decreased FSLv/glom and increased FPW compared with NA (P < 0.005 for both, ANOVA). The albumin excretion rate was inversely related to Nv(epi/glom) and FSLv/glom and directly to FPW (P < 0.0005 for all), whereas there was no correlation with Epi N/glom. In conclusion, changes in podocyte structure and density occur since the early stages of diabetic nephropathy and might contribute to increasing albuminuria in type 2 diabetic patients. These findings also suggest that in white type 2 diabetic patients, the density of podocytes may be functionally more relevant than the absolute number. |
| doi_str_mv | 10.2337/diabetes.52.4.1031 |
| format | Article |
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Studies in patients with type 2 diabetes</title><source>MEDLINE</source><source>EZB Electronic Journals Library</source><creator>DALLA VESTRA, Michele ; MASIERO, Alessandra ; ROITER, Anna Maria ; SALLER, Alois ; CREPALDI, Gaetano ; FIORETTO, Paola</creator><creatorcontrib>DALLA VESTRA, Michele ; MASIERO, Alessandra ; ROITER, Anna Maria ; SALLER, Alois ; CREPALDI, Gaetano ; FIORETTO, Paola</creatorcontrib><description>Podocyte structural changes have been suggested to be involved in the pathogenesis of albuminuria in diabetes. We evaluated podocytes density, number, and structure in 67 white patients with type 2 diabetes: 21 normoalbuminuric (NA), 23 microalbuminuric (MA), and 23 proteinuric (P). Kidney function and biopsy studies were performed; 20 kidney donors served as control subjects. Electron microscopic morphometric analysis was used to estimate numerical density of podocytes per glomerulus [Nv(epi/glom)], filtration slit length density per glomerulus (FSLv/glom), and foot process width (FPW). The number of podocytes per glomerulus (Epi N/glom) was obtained by multiplying Nv(epi/glom) by mean glomerular volume. Nv(epi/glom) was significantly decreased in all type 2 diabetic groups compared with control subjects and was lower in MA and P than in NA (P < 0.0001, ANOVA). Epi N/glom was lower in MA and P patients compared with control subjects (P < 0.002, ANOVA); however, there were no significant differences among the type 2 diabetic groups. In addition, MA and P had decreased FSLv/glom and increased FPW compared with NA (P < 0.005 for both, ANOVA). The albumin excretion rate was inversely related to Nv(epi/glom) and FSLv/glom and directly to FPW (P < 0.0005 for all), whereas there was no correlation with Epi N/glom. In conclusion, changes in podocyte structure and density occur since the early stages of diabetic nephropathy and might contribute to increasing albuminuria in type 2 diabetic patients. These findings also suggest that in white type 2 diabetic patients, the density of podocytes may be functionally more relevant than the absolute number.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/diabetes.52.4.1031</identifier><identifier>PMID: 12663476</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Aged ; Albuminuria ; Basement Membrane - pathology ; Biological and medical sciences ; Blood Pressure ; Body Mass Index ; Complications and side effects ; Development and progression ; Diabetes ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic nephropathies ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - physiopathology ; Diabetic nephropathy ; Female ; Fundamental and applied biological sciences. Psychology ; Glomerular Filtration Rate ; Glycated Hemoglobin A - analysis ; Humans ; Kidney - physiopathology ; Kidney Glomerulus - pathology ; Kinetics ; Longitudinal studies ; Male ; Middle Aged ; Pathogenesis ; Permeability ; Type 2 diabetes</subject><ispartof>Diabetes (New York, N.Y.), 2003-04, Vol.52 (4), p.1031-1035</ispartof><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 American Diabetes Association</rights><rights>Copyright American Diabetes Association Apr 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14698981$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12663476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DALLA VESTRA, Michele</creatorcontrib><creatorcontrib>MASIERO, Alessandra</creatorcontrib><creatorcontrib>ROITER, Anna Maria</creatorcontrib><creatorcontrib>SALLER, Alois</creatorcontrib><creatorcontrib>CREPALDI, Gaetano</creatorcontrib><creatorcontrib>FIORETTO, Paola</creatorcontrib><title>Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>Podocyte structural changes have been suggested to be involved in the pathogenesis of albuminuria in diabetes. We evaluated podocytes density, number, and structure in 67 white patients with type 2 diabetes: 21 normoalbuminuric (NA), 23 microalbuminuric (MA), and 23 proteinuric (P). Kidney function and biopsy studies were performed; 20 kidney donors served as control subjects. Electron microscopic morphometric analysis was used to estimate numerical density of podocytes per glomerulus [Nv(epi/glom)], filtration slit length density per glomerulus (FSLv/glom), and foot process width (FPW). The number of podocytes per glomerulus (Epi N/glom) was obtained by multiplying Nv(epi/glom) by mean glomerular volume. Nv(epi/glom) was significantly decreased in all type 2 diabetic groups compared with control subjects and was lower in MA and P than in NA (P < 0.0001, ANOVA). Epi N/glom was lower in MA and P patients compared with control subjects (P < 0.002, ANOVA); however, there were no significant differences among the type 2 diabetic groups. In addition, MA and P had decreased FSLv/glom and increased FPW compared with NA (P < 0.005 for both, ANOVA). The albumin excretion rate was inversely related to Nv(epi/glom) and FSLv/glom and directly to FPW (P < 0.0005 for all), whereas there was no correlation with Epi N/glom. In conclusion, changes in podocyte structure and density occur since the early stages of diabetic nephropathy and might contribute to increasing albuminuria in type 2 diabetic patients. These findings also suggest that in white type 2 diabetic patients, the density of podocytes may be functionally more relevant than the absolute number.</description><subject>Aged</subject><subject>Albuminuria</subject><subject>Basement Membrane - pathology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic nephropathies</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic nephropathy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glomerular Filtration Rate</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidney Glomerulus - pathology</subject><subject>Kinetics</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Permeability</subject><subject>Type 2 diabetes</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0V-LEzEQAPAgilerX8AHCYKHD7c1_zbZPMlR9Dwo3IMKvsiSZmfblG12L8nq7bc30h5SKfMwZPgxmUwQek3JgnGuPjTOrCFBXJRsIRaUcPoEzajmuuBM_XiKZoRQVlCl1QV6EeOOECJzPEcXlEnJhZIz9PM24qFvejslwM7vxjDhAB38Mj7lMz7c4Sz2MGxDP5i0nT7ir2lsHMS_IFcc-BTxb5e2OE0DYIYfJ3uJnrWmi_DqmOfo--dP35ZfitXdze3yelVsBNGpsLq0ZaO5FWvSWGuMMkpTK0mpS2C0aVptWsk4pUYLLhg3lVSSMKmtFGW75nN0eeg7hP5-hJjqvYsWus546MdYK05LWQma4dv_4K4fg8-z1YxKoSotqoyuDmhjOqidb_sUjN2Ah2C63kPrcvlaayUkz1ufo-IMz9HA3tlz_v2JzyTBQ9qYMca6ulmd0Ktz1PZdBxuo8w6Xdyf8zfF143oPTT0Etzdhqh-_O4N3R2CiNV0bjLcu_nNC6kpXlP8BoxC4Yw</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>DALLA VESTRA, Michele</creator><creator>MASIERO, Alessandra</creator><creator>ROITER, Anna Maria</creator><creator>SALLER, Alois</creator><creator>CREPALDI, Gaetano</creator><creator>FIORETTO, Paola</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Is podocyte injury relevant in diabetic nephropathy? 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Psychology</topic><topic>Glomerular Filtration Rate</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidney Glomerulus - pathology</topic><topic>Kinetics</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Permeability</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DALLA VESTRA, Michele</creatorcontrib><creatorcontrib>MASIERO, Alessandra</creatorcontrib><creatorcontrib>ROITER, Anna Maria</creatorcontrib><creatorcontrib>SALLER, Alois</creatorcontrib><creatorcontrib>CREPALDI, Gaetano</creatorcontrib><creatorcontrib>FIORETTO, Paola</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: High School</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DALLA VESTRA, Michele</au><au>MASIERO, Alessandra</au><au>ROITER, Anna Maria</au><au>SALLER, Alois</au><au>CREPALDI, Gaetano</au><au>FIORETTO, Paola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>52</volume><issue>4</issue><spage>1031</spage><epage>1035</epage><pages>1031-1035</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>Podocyte structural changes have been suggested to be involved in the pathogenesis of albuminuria in diabetes. We evaluated podocytes density, number, and structure in 67 white patients with type 2 diabetes: 21 normoalbuminuric (NA), 23 microalbuminuric (MA), and 23 proteinuric (P). Kidney function and biopsy studies were performed; 20 kidney donors served as control subjects. Electron microscopic morphometric analysis was used to estimate numerical density of podocytes per glomerulus [Nv(epi/glom)], filtration slit length density per glomerulus (FSLv/glom), and foot process width (FPW). The number of podocytes per glomerulus (Epi N/glom) was obtained by multiplying Nv(epi/glom) by mean glomerular volume. Nv(epi/glom) was significantly decreased in all type 2 diabetic groups compared with control subjects and was lower in MA and P than in NA (P < 0.0001, ANOVA). Epi N/glom was lower in MA and P patients compared with control subjects (P < 0.002, ANOVA); however, there were no significant differences among the type 2 diabetic groups. In addition, MA and P had decreased FSLv/glom and increased FPW compared with NA (P < 0.005 for both, ANOVA). The albumin excretion rate was inversely related to Nv(epi/glom) and FSLv/glom and directly to FPW (P < 0.0005 for all), whereas there was no correlation with Epi N/glom. In conclusion, changes in podocyte structure and density occur since the early stages of diabetic nephropathy and might contribute to increasing albuminuria in type 2 diabetic patients. These findings also suggest that in white type 2 diabetic patients, the density of podocytes may be functionally more relevant than the absolute number.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>12663476</pmid><doi>10.2337/diabetes.52.4.1031</doi><tpages>5</tpages></addata></record> |
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| ispartof | Diabetes (New York, N.Y.), 2003-04, Vol.52 (4), p.1031-1035 |
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| subjects | Aged Albuminuria Basement Membrane - pathology Biological and medical sciences Blood Pressure Body Mass Index Complications and side effects Development and progression Diabetes Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetic nephropathies Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Diabetic nephropathy Female Fundamental and applied biological sciences. Psychology Glomerular Filtration Rate Glycated Hemoglobin A - analysis Humans Kidney - physiopathology Kidney Glomerulus - pathology Kinetics Longitudinal studies Male Middle Aged Pathogenesis Permeability Type 2 diabetes |
| title | Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes |
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