Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleurum rotundifolium

The MeOH extract of the fruits of Bupleurum rotundifolium showed inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth (GI50: 6.25 μg/ml). From this extract, 10 new ursane-type triterpene glycosides viz. three 3-O-triosides (called rotundifoliosides A, I, and J) of 13β,28-epoxy...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2003, Vol.51(4), pp.365-372
Hauptverfasser:	Fujioka, Toshihiro, Yoshida, Keisuke, Fujii, Hiroko, Nagao, Tsuneatsu, Okabe, Hikaru, Mihashi, Kunihide
Format:	Artikel
Sprache:	eng
Schlagworte:	13β,28-epoxyursane-type triterpene glycoside Animals antiproliferative activity Apiaceae Bupleurum Bupleurum rotundifolium Fruit Growth Inhibitors - chemistry Growth Inhibitors - isolation & purification Growth Inhibitors - pharmacology Humans Mice Oleanolic Acid - analogs & derivatives Oleanolic Acid - chemistry Oleanolic Acid - isolation & purification Oleanolic Acid - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - physiology Umbelliferae
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