No Impact of Cross‐Reactive Group Human Leucocyte Antigen Class I Matching on Long‐Term Kidney Graft Survival

No Impact of Cross‐Reactive Group Human Leucocyte Antigen Class I Matching on Long‐Term Kidney Graft Survival

The aim was to elucidate the effect of matching for the broad human leucocyte antigen (HLA)‐A and ‐B cross‐reactive groups (CREGs) of major histocompatibility complex (MHC) class I on long‐term kidney graft survival. Material and methods: 1304 patients transplanted at Rigshospitalet between 1968 and...

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Veröffentlicht in:Scandinavian journal of immunology 2003-04, Vol.57 (4), p.362-365
Hauptverfasser: Egfjord, M., Jakobsen, B. K., Ladefoged, J.
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Sprache:eng
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Adult
Female
Graft Survival - immunology
Histocompatibility Testing
HLA-A Antigens - immunology
HLA-B Antigens - immunology
Humans
Kidney Transplantation - adverse effects
Kidney Transplantation - immunology
Male
Proportional Hazards Models
Retrospective Studies
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container_title Scandinavian journal of immunology
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creator Egfjord, M.
Jakobsen, B. K.
Ladefoged, J.
description The aim was to elucidate the effect of matching for the broad human leucocyte antigen (HLA)‐A and ‐B cross‐reactive groups (CREGs) of major histocompatibility complex (MHC) class I on long‐term kidney graft survival. Material and methods: 1304 patients transplanted at Rigshospitalet between 1968 and 1999 with a cadaver kidney and followed until 2000. The definition of CREGs based on amino acid residues was according to United Network for Organ Sharing (UNOS) (1996). Graft‐survival analyses (Kaplan Meier) were performed for all cases and for cases censored for death with functioning grafts. Results: Univariate analysis showed no effect of any specific donor or recipient CREG on graft survival. Contrary to some reports in the literature, the absolute and relative number of CREG shares and of CREG mismatches had no effect on graft survival even when censored for graft loss because of death. However, graft survival was dependent on DR shares (P 
doi_str_mv 10.1046/j.1365-3083.2003.01203.x
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Contrary to some reports in the literature, the absolute and relative number of CREG shares and of CREG mismatches had no effect on graft survival even when censored for graft loss because of death. However, graft survival was dependent on DR shares (P &lt; 0.05), indicating that matching for MHC class II seems to be more important than that for the broad MHC class I phenotype represented by CREG.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1046/j.1365-3083.2003.01203.x</identifier><identifier>PMID: 12662299</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Female ; Graft Survival - immunology ; Histocompatibility Testing ; HLA-A Antigens - immunology ; HLA-B Antigens - immunology ; Humans ; Kidney Transplantation - adverse effects ; Kidney Transplantation - immunology ; Male ; Proportional Hazards Models ; Retrospective Studies</subject><ispartof>Scandinavian journal of immunology, 2003-04, Vol.57 (4), p.362-365</ispartof><rights>Copyright Blackwell Scientific Publications Ltd. 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K.</creatorcontrib><creatorcontrib>Ladefoged, J.</creatorcontrib><title>No Impact of Cross‐Reactive Group Human Leucocyte Antigen Class I Matching on Long‐Term Kidney Graft Survival</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>The aim was to elucidate the effect of matching for the broad human leucocyte antigen (HLA)‐A and ‐B cross‐reactive groups (CREGs) of major histocompatibility complex (MHC) class I on long‐term kidney graft survival. Material and methods: 1304 patients transplanted at Rigshospitalet between 1968 and 1999 with a cadaver kidney and followed until 2000. The definition of CREGs based on amino acid residues was according to United Network for Organ Sharing (UNOS) (1996). Graft‐survival analyses (Kaplan Meier) were performed for all cases and for cases censored for death with functioning grafts. Results: Univariate analysis showed no effect of any specific donor or recipient CREG on graft survival. Contrary to some reports in the literature, the absolute and relative number of CREG shares and of CREG mismatches had no effect on graft survival even when censored for graft loss because of death. 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subjects Adult
Female
Graft Survival - immunology
Histocompatibility Testing
HLA-A Antigens - immunology
HLA-B Antigens - immunology
Humans
Kidney Transplantation - adverse effects
Kidney Transplantation - immunology
Male
Proportional Hazards Models
Retrospective Studies
title No Impact of Cross‐Reactive Group Human Leucocyte Antigen Class I Matching on Long‐Term Kidney Graft Survival
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