L-687,306 : a functionally selective and potent muscarinic M1 receptor agonist

The oxadiazole L-687,306 is a high affinity muscarinic agonist with a N-methylscopolamine/oxotremorine-M binding profile predictive of a partial agonist. L-687,306 showed marked selectivity in functional pharmacological assays. L-687,306 was a partial agonist at muscarinic M1 receptors in the rat ga...

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Veröffentlicht in:	European journal of pharmacology 1992-04, Vol.215 (1), p.135-136
Hauptverfasser:	FREEDMAN, S. B, SHIL PATEL, HARGREAVES, R, HARLEY, E. A, IVERSEN, L. L, BAKER, R, SHOWELL, G. A, SAUNDERS, J, MCKNIGHT, A, NEWBERRY, N, SCHOLEY, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic Cholinergic system Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Ganglia, Spinal - ultrastructure Guinea Pigs Medical sciences Muscarine - pharmacology Myenteric Plexus - drug effects Myenteric Plexus - physiology Neuromuscular Junction - drug effects Neuromuscular Junction - physiology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oxadiazoles - pharmacology Pharmacology. Drug treatments Rats Receptors, Muscarinic - physiology
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