Dual action of neutral sphingomyelinase on rat hepatocytes: Activation of cholesteryl ester metabolism and biliary cholesterol secretion and inhibition of VLDL secretion

To address the role of cell membrane neutral sphingomyelinase (EC 3.1.4.12; SMase) in the regulation of cholesterol metabolism in the liver parenchymal cell, we examined the effect of exogenous neutral SMase on the metabolism of cholesteryl esters and the secretion of VLDL and biliary lipids in isol...

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Veröffentlicht in:	Lipids 2003-01, Vol.38 (1), p.53-63
Hauptverfasser:	Liza, Mariana, Chico, Yolanda, Fresnedo, Olatz, Ochoa, Begoña
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins B - genetics Apolipoproteins B - metabolism Bile Bile Acids and Salts - biosynthesis Cells, Cultured Cholesterol Cholesterol - metabolism Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism Cholesterol Esters - metabolism Esters Female Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - metabolism Lipids Lipoproteins, VLDL - metabolism Metabolism Phospholipids - biosynthesis Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Rodents Sphingomyelin Phosphodiesterase - metabolism Sphingomyelin Phosphodiesterase - pharmacology Sterol O-Acyltransferase - genetics Sterol O-Acyltransferase - metabolism Sterol O-Acyltransferase 2
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