Different patterns of regulation of Tyr-phosphorylated STAT1 and STAT3 in human hepatoma Hep3B cells by the phosphatase inhibitor orthovanadate

The cellular physiology of signal transducer and activator of transcription protein family (STAT) transcription factors includes activation by Tyr-phosphorylation (PY) in cytokine and growth factor receptor complexes at the level of plasma membrane rafts, subsequent cytoplasmic transit and nuclear i...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2003-04, Vol.412 (2), p.242-250
Hauptverfasser:	Sehgal, Pravin B, Kumar, Vinita, Guo, Gary, Murray, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport, Active - drug effects Carcinoma, Hepatocellular - metabolism Cytokines DNA, Neoplasm - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Drug Stability Enzyme Inhibitors - pharmacology Humans Interferon Interferon-gamma - pharmacology Interleukin Interleukin-6 - pharmacology Kinetics Liver Neoplasms - metabolism Orthovanadate Phosphorylation Protein tyrosine phosphatases Protein Tyrosine Phosphatases - antagonists & inhibitors Recombinant Proteins Signal transduction Signal Transduction - drug effects STAT STAT1 Transcription Factor STAT3 Transcription Factor Trans-Activators - chemistry Trans-Activators - metabolism Transcription factors Tumor Cells, Cultured Tyr-phosphorylation Tyrosine - chemistry Vanadates - pharmacology
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