Altered myogenesis in Six1-deficient mice

Six homeoproteins are expressed in several tissues, including muscle, during vertebrate embryogenesis, suggesting that they may be involved in diverse differentiation processes. To determine the functions of the Six1 gene during myogenesis, we constructed Six1 -deficient mice by replacing its first...

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Veröffentlicht in:	Development (Cambridge) 2003-05, Vol.130 (10), p.2239-2252
Hauptverfasser:	Laclef, Christine, Hamard, Ghislaine, Demignon, Josiane, Souil, Evelyne, Houbron, Christophe, Maire, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Cell Differentiation - physiology Cell Movement - physiology Embryo, Mammalian - anatomy & histology Embryo, Mammalian - physiology Female Gene Targeting Homeodomain Proteins - genetics Homeodomain Proteins - metabolism In Situ Hybridization In Situ Nick-End Labeling Male Mice Mice, Transgenic Muscle Development - genetics Muscle Development - physiology Muscle, Skeletal - pathology Muscle, Skeletal - physiology MyoD Protein - genetics MyoD Protein - metabolism Myogenin - genetics Myogenin - metabolism Phenotype Ribs - pathology Sternum - pathology
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