Nuclear Localisation Sequence Templated Nonviral Gene Delivery Vectors: Investigation of Intracellular Trafficking Events of LMD and LD Vector Systems

The impact of a peptide that contains a nuclear localisation sequence (NLS) on intracellular DNA trafficking was studied. We used the adenoviral core peptide mu and an SV40 NLS peptide to condense plasmid DNA (pDNA) prior to formulation with 3β-[N-(N′, N′-dimethylaminoethane)carbamoyl]cholesterol/di...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2003-04, Vol.4 (4), p.286-298
Hauptverfasser:	Keller, Michael, Harbottle, Richard P, Perouzel, Eric, Colin, Morvane, Shah, Imran, Rahim, Ahad, Vaysse, Laurence, Bergau, Anna, Moritz, Sylviane, Brahimi-Horn, Christiane, Coutelle, Charles, Miller, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Carbocyanines Cell Line Cholesterol - analogs & derivatives Cholesterol - chemistry DNA - chemistry DNA - metabolism Electrophoretic Mobility Shift Assay Fluorescent Dyes gene technology gene therapy Gene Transfer Techniques Genetic Vectors Glycoside Hydrolases - genetics Humans Intracellular Space - metabolism lipids Liposomes Microscopy, Confocal nuclear localisation sequence Nuclear Localization Signals - chemistry Oligopeptides - chemistry Oligopeptides - genetics Oligopeptides - metabolism peptides Peptides - chemistry Peptides - genetics Peptides - metabolism Phosphatidylethanolamines - chemistry Plasmids Polyethylene Glycols - chemistry Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Simian virus 40 Transfection
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