Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS

The influenza A virus NS1 protein (NS1A protein) binds and inhibits the function of the 30-kDa subunit of CPSF, a cellular factor that is required for the 3′-end processing of cellular pre-mRNAs. Here we generate a recombinant influenza A/Udorn/72 virus that encodes an NS1A protein containing a muta...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2003-03, Vol.307 (2), p.386-395
Hauptverfasser:	Noah, Diana L, Twu, Karen Y, Krug, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cleavage And Polyadenylation Specificity Factor - metabolism CPSF Gene Expression Regulation, Viral Humans IFN production IFN-independent cellular antiviral response Influenza A virus Influenza A virus - physiology Interferon-alpha - genetics Interferon-alpha - physiology Interferon-beta - genetics Interferon-beta - physiology NS1A protein Posttranscriptional regulation of cellular gene expression Protein Binding RNA Precursors - metabolism RNA, Messenger - metabolism Viral Nonstructural Proteins - metabolism Virus Replication
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