QSAR study of quinolinediones with inhibitory activity of endothelium-Dependent vasorelaxation by CoMSIA

The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vasorelaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q 2 (0.741) and r 2 (0.960) values, gave reliability to the prediction of inhibito...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2003-05, Vol.11 (9), p.2019-2023
Hauptverfasser:	Choo, Hea-Young Park, Choi, Suyoung, Ryu, Chung-Kyu, Kim, Hwa-Jung, Lee, In Young, Pae b, Ae Nim, Koh, Hun Yeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Medical sciences Miscellaneous Pharmacology. Drug treatments Quantitative Structure-Activity Relationship Quinolines - chemistry Quinolines - pharmacology Rats Vasodilation - drug effects Vasodilation - physiology
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