Evaluation of tissue polypeptide antigen serum levels for monitoring disease activity during chemotherapy in patients with transitional carcinoma of the urinary tract
In 28 patients with transitional carcinoma of the urinary tract, all treated with chemotherapy, serial measurements of serum tissue polypeptide antigen (TPA) were performed and correlated to clinical evaluations of response. At the start of chemotherapy elevated levels of TPA were found in 4 out of...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1992-08, Vol.118 (8), p.626-628 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | VAN DER GAAST, A KIRKELS, W. J BLIJENBERG, B. G SPLINTER, T. A. W |
| description | In 28 patients with transitional carcinoma of the urinary tract, all treated with chemotherapy, serial measurements of serum tissue polypeptide antigen (TPA) were performed and correlated to clinical evaluations of response. At the start of chemotherapy elevated levels of TPA were found in 4 out of 14 patients with T2-4NO-2MO tumours and in 7 out of 14 patients with distant metastases. In most patients with elevated TPA levels who responded to chemotherapy, TPA levels rapidly returned to normal. False positive elevations of TPA were observed in 2 patients. It is concluded that serial measurement of TPA for monitoring disease activity has limited value because of the low sensitivity of TPA, especially for patients with early-stage cancer, and because of the occurrence of false positive results. |
| doi_str_mv | 10.1007/BF01211809 |
| format | Article |
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J ; BLIJENBERG, B. G ; SPLINTER, T. A. W</creator><creatorcontrib>VAN DER GAAST, A ; KIRKELS, W. J ; BLIJENBERG, B. G ; SPLINTER, T. A. W</creatorcontrib><description>In 28 patients with transitional carcinoma of the urinary tract, all treated with chemotherapy, serial measurements of serum tissue polypeptide antigen (TPA) were performed and correlated to clinical evaluations of response. At the start of chemotherapy elevated levels of TPA were found in 4 out of 14 patients with T2-4NO-2MO tumours and in 7 out of 14 patients with distant metastases. In most patients with elevated TPA levels who responded to chemotherapy, TPA levels rapidly returned to normal. False positive elevations of TPA were observed in 2 patients. It is concluded that serial measurement of TPA for monitoring disease activity has limited value because of the low sensitivity of TPA, especially for patients with early-stage cancer, and because of the occurrence of false positive results.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/BF01211809</identifier><identifier>PMID: 1517284</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Antigens, Neoplasm - blood ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Carboplatin - therapeutic use ; Carcinoma, Transitional Cell - drug therapy ; Carcinoma, Transitional Cell - immunology ; Carcinoma, Transitional Cell - pathology ; Cisplatin - therapeutic use ; False Positive Reactions ; Female ; Humans ; Immunoassay - methods ; Male ; Medical sciences ; Methotrexate - therapeutic use ; Middle Aged ; Nephrology. Urinary tract diseases ; Organoplatinum Compounds - therapeutic use ; Peptides - blood ; Predictive Value of Tests ; Tissue Polypeptide Antigen ; Tumors of the urinary system ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - immunology ; Urinary Bladder Neoplasms - pathology ; Urinary tract. 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J</creatorcontrib><creatorcontrib>BLIJENBERG, B. G</creatorcontrib><creatorcontrib>SPLINTER, T. A. W</creatorcontrib><title>Evaluation of tissue polypeptide antigen serum levels for monitoring disease activity during chemotherapy in patients with transitional carcinoma of the urinary tract</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>In 28 patients with transitional carcinoma of the urinary tract, all treated with chemotherapy, serial measurements of serum tissue polypeptide antigen (TPA) were performed and correlated to clinical evaluations of response. At the start of chemotherapy elevated levels of TPA were found in 4 out of 14 patients with T2-4NO-2MO tumours and in 7 out of 14 patients with distant metastases. In most patients with elevated TPA levels who responded to chemotherapy, TPA levels rapidly returned to normal. False positive elevations of TPA were observed in 2 patients. It is concluded that serial measurement of TPA for monitoring disease activity has limited value because of the low sensitivity of TPA, especially for patients with early-stage cancer, and because of the occurrence of false positive results.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Neoplasm - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carboplatin - therapeutic use</subject><subject>Carcinoma, Transitional Cell - drug therapy</subject><subject>Carcinoma, Transitional Cell - immunology</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Cisplatin - therapeutic use</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoassay - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - therapeutic use</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Organoplatinum Compounds - therapeutic use</subject><subject>Peptides - blood</subject><subject>Predictive Value of Tests</subject><subject>Tissue Polypeptide Antigen</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - immunology</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary tract. 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W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-484cc0f73ba162b3bf179b72391f89265262be4f55e8d1d1495e98ecd5bd77043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Neoplasm - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carboplatin - therapeutic use</topic><topic>Carcinoma, Transitional Cell - drug therapy</topic><topic>Carcinoma, Transitional Cell - immunology</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Cisplatin - therapeutic use</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoassay - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methotrexate - therapeutic use</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Organoplatinum Compounds - therapeutic use</topic><topic>Peptides - blood</topic><topic>Predictive Value of Tests</topic><topic>Tissue Polypeptide Antigen</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Urinary Bladder Neoplasms - immunology</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DER GAAST, A</creatorcontrib><creatorcontrib>KIRKELS, W. J</creatorcontrib><creatorcontrib>BLIJENBERG, B. G</creatorcontrib><creatorcontrib>SPLINTER, T. A. 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W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of tissue polypeptide antigen serum levels for monitoring disease activity during chemotherapy in patients with transitional carcinoma of the urinary tract</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>1992-08</date><risdate>1992</risdate><volume>118</volume><issue>8</issue><spage>626</spage><epage>628</epage><pages>626-628</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>In 28 patients with transitional carcinoma of the urinary tract, all treated with chemotherapy, serial measurements of serum tissue polypeptide antigen (TPA) were performed and correlated to clinical evaluations of response. At the start of chemotherapy elevated levels of TPA were found in 4 out of 14 patients with T2-4NO-2MO tumours and in 7 out of 14 patients with distant metastases. In most patients with elevated TPA levels who responded to chemotherapy, TPA levels rapidly returned to normal. False positive elevations of TPA were observed in 2 patients. It is concluded that serial measurement of TPA for monitoring disease activity has limited value because of the low sensitivity of TPA, especially for patients with early-stage cancer, and because of the occurrence of false positive results.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>1517284</pmid><doi>10.1007/BF01211809</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Aged Antigens, Neoplasm - blood Biological and medical sciences Biomarkers, Tumor - blood Carboplatin - therapeutic use Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - immunology Carcinoma, Transitional Cell - pathology Cisplatin - therapeutic use False Positive Reactions Female Humans Immunoassay - methods Male Medical sciences Methotrexate - therapeutic use Middle Aged Nephrology. Urinary tract diseases Organoplatinum Compounds - therapeutic use Peptides - blood Predictive Value of Tests Tissue Polypeptide Antigen Tumors of the urinary system Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - pathology Urinary tract. Prostate gland |
| title | Evaluation of tissue polypeptide antigen serum levels for monitoring disease activity during chemotherapy in patients with transitional carcinoma of the urinary tract |
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