Evaluation of transition zone and lateral sextant biopsies for prostate cancer detection after initial sextant biopsy
To assess the value of transition zone and lateral sextant biopsies for the detection of prostate cancer after a previous sextant biopsy was negative. A total of 74 prostates after radical prostatectomy were used to perform biopsies ex vivo. First, a sextant biopsy was taken, then two different rebi...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2003-04, Vol.61 (4), p.748-753 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Fink, Klaus G Hutarew, Georg Esterbauer, Brigitte Pytel, Akos Jungwirth, Andreas Dietze, Otto Schmeller, Nikolaus T |
| description | To assess the value of transition zone and lateral sextant biopsies for the detection of prostate cancer after a previous sextant biopsy was negative.
A total of 74 prostates after radical prostatectomy were used to perform biopsies ex vivo. First, a sextant biopsy was taken, then two different rebiopsy techniques were performed. Rebiopsy technique A consisted of a laterally placed sextant biopsy and two cores per side of the transition zones only. Rebiopsy technique B included a standard sextant biopsy and two cores per side from the lateral areas of the prostate. The biopsies were taken using ultrasound guidance to sample the areas of interest precisely.
The initial sextant biopsy found 39 prostate cancers. Rebiopsy technique A found 12 cancers (34%). In this group, a laterally placed sextant biopsy found 12 cancers; transition zone biopsies revealed cancer in 5 cases, but no additional tumor was found. Rebiopsy technique B detected 23 prostate cancers (66%). Fourteen tumors were found after a second standard sextant biopsy, and nine additional tumors were found in the lateral areas.
Sextant biopsy has a low sensitivity of only 53%. A biopsy including the transition zones is not the ideal technique for detecting the remaining tumors. Therefore, transition zone biopsies should be reserved for patients with multiple previous negative biopsies of the peripheral zone. A subsequent sextant biopsy with additional cores from the lateral areas of the prostate is favorable if rebiopsy is necessary after a negative sextant biopsy. |
| doi_str_mv | 10.1016/S0090-4295(02)02502-5 |
| format | Article |
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A total of 74 prostates after radical prostatectomy were used to perform biopsies ex vivo. First, a sextant biopsy was taken, then two different rebiopsy techniques were performed. Rebiopsy technique A consisted of a laterally placed sextant biopsy and two cores per side of the transition zones only. Rebiopsy technique B included a standard sextant biopsy and two cores per side from the lateral areas of the prostate. The biopsies were taken using ultrasound guidance to sample the areas of interest precisely.
The initial sextant biopsy found 39 prostate cancers. Rebiopsy technique A found 12 cancers (34%). In this group, a laterally placed sextant biopsy found 12 cancers; transition zone biopsies revealed cancer in 5 cases, but no additional tumor was found. Rebiopsy technique B detected 23 prostate cancers (66%). Fourteen tumors were found after a second standard sextant biopsy, and nine additional tumors were found in the lateral areas.
Sextant biopsy has a low sensitivity of only 53%. A biopsy including the transition zones is not the ideal technique for detecting the remaining tumors. Therefore, transition zone biopsies should be reserved for patients with multiple previous negative biopsies of the peripheral zone. A subsequent sextant biopsy with additional cores from the lateral areas of the prostate is favorable if rebiopsy is necessary after a negative sextant biopsy.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/S0090-4295(02)02502-5</identifier><identifier>PMID: 12670559</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biopsy, Needle - methods ; Biopsy, Needle - statistics & numerical data ; False Negative Reactions ; Genital system. Mammary gland ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Palpation ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prostate - diagnostic imaging ; Prostate - pathology ; Prostate-Specific Antigen - blood ; Prostatectomy ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Reoperation ; Sensitivity and Specificity ; Ultrasonography</subject><ispartof>Urology (Ridgewood, N.J.), 2003-04, Vol.61 (4), p.748-753</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-23d91a67c4a1165f87cda2856d6405cdaa24bdcfb0a06e99b7f6d40a8e5f7ee3</citedby><cites>FETCH-LOGICAL-c486t-23d91a67c4a1165f87cda2856d6405cdaa24bdcfb0a06e99b7f6d40a8e5f7ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0090-4295(02)02502-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14711706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12670559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fink, Klaus G</creatorcontrib><creatorcontrib>Hutarew, Georg</creatorcontrib><creatorcontrib>Esterbauer, Brigitte</creatorcontrib><creatorcontrib>Pytel, Akos</creatorcontrib><creatorcontrib>Jungwirth, Andreas</creatorcontrib><creatorcontrib>Dietze, Otto</creatorcontrib><creatorcontrib>Schmeller, Nikolaus T</creatorcontrib><title>Evaluation of transition zone and lateral sextant biopsies for prostate cancer detection after initial sextant biopsy</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>To assess the value of transition zone and lateral sextant biopsies for the detection of prostate cancer after a previous sextant biopsy was negative.
A total of 74 prostates after radical prostatectomy were used to perform biopsies ex vivo. First, a sextant biopsy was taken, then two different rebiopsy techniques were performed. Rebiopsy technique A consisted of a laterally placed sextant biopsy and two cores per side of the transition zones only. Rebiopsy technique B included a standard sextant biopsy and two cores per side from the lateral areas of the prostate. The biopsies were taken using ultrasound guidance to sample the areas of interest precisely.
The initial sextant biopsy found 39 prostate cancers. Rebiopsy technique A found 12 cancers (34%). In this group, a laterally placed sextant biopsy found 12 cancers; transition zone biopsies revealed cancer in 5 cases, but no additional tumor was found. Rebiopsy technique B detected 23 prostate cancers (66%). Fourteen tumors were found after a second standard sextant biopsy, and nine additional tumors were found in the lateral areas.
Sextant biopsy has a low sensitivity of only 53%. A biopsy including the transition zones is not the ideal technique for detecting the remaining tumors. Therefore, transition zone biopsies should be reserved for patients with multiple previous negative biopsies of the peripheral zone. A subsequent sextant biopsy with additional cores from the lateral areas of the prostate is favorable if rebiopsy is necessary after a negative sextant biopsy.</description><subject>Biological and medical sciences</subject><subject>Biopsy, Needle - methods</subject><subject>Biopsy, Needle - statistics & numerical data</subject><subject>False Negative Reactions</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Palpation</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prostate - diagnostic imaging</subject><subject>Prostate - pathology</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Reoperation</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7rj6E5RcFD20VjKdpHNaZFk_YMGDew_VSQUiPd1jkl5cf73ZmcEFL55Sgeetj4exlwLeCxD6w3cAC10vrXoL8h1IBbJTj9hGKGk6a616zDZ_kTP2rJQfAKC1Nk_ZmZDagFJ2w9arW5xWrGmZ-RJ5zTiXdPj9XmbiOAc-YaWMEy_0q-Jc-ZiWfUlUeFwy3-el1AZwj7OnzANV8oc8xhbjaW7d_g3fPWdPIk6FXpzec3bz6erm8kt3_e3z18uP153vB107uQ1WoDa-RyG0ioPxAeWgdNA9qFaj7Mfg4wgImqwdTdShBxxIRUO0PWdvjm3blj9XKtXtUvE0TTjTshZntkKBHmQD1RH07ZySKbp9TjvMd06Au9ftDrrdvUsH0h10O9Vyr04D1nFH4SF18tuA1ycAi8cpNr0-lQeuN0IY0I27OHLUbNwmyq74RM1oSLn5dGFJ_1nlDwxpn4Y</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Fink, Klaus G</creator><creator>Hutarew, Georg</creator><creator>Esterbauer, Brigitte</creator><creator>Pytel, Akos</creator><creator>Jungwirth, Andreas</creator><creator>Dietze, Otto</creator><creator>Schmeller, Nikolaus T</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Evaluation of transition zone and lateral sextant biopsies for prostate cancer detection after initial sextant biopsy</title><author>Fink, Klaus G ; Hutarew, Georg ; Esterbauer, Brigitte ; Pytel, Akos ; Jungwirth, Andreas ; Dietze, Otto ; Schmeller, Nikolaus T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-23d91a67c4a1165f87cda2856d6405cdaa24bdcfb0a06e99b7f6d40a8e5f7ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy, Needle - methods</topic><topic>Biopsy, Needle - statistics & numerical data</topic><topic>False Negative Reactions</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Palpation</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prostate - diagnostic imaging</topic><topic>Prostate - pathology</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Reoperation</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fink, Klaus G</creatorcontrib><creatorcontrib>Hutarew, Georg</creatorcontrib><creatorcontrib>Esterbauer, Brigitte</creatorcontrib><creatorcontrib>Pytel, Akos</creatorcontrib><creatorcontrib>Jungwirth, Andreas</creatorcontrib><creatorcontrib>Dietze, Otto</creatorcontrib><creatorcontrib>Schmeller, Nikolaus T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fink, Klaus G</au><au>Hutarew, Georg</au><au>Esterbauer, Brigitte</au><au>Pytel, Akos</au><au>Jungwirth, Andreas</au><au>Dietze, Otto</au><au>Schmeller, Nikolaus T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of transition zone and lateral sextant biopsies for prostate cancer detection after initial sextant biopsy</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>61</volume><issue>4</issue><spage>748</spage><epage>753</epage><pages>748-753</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>To assess the value of transition zone and lateral sextant biopsies for the detection of prostate cancer after a previous sextant biopsy was negative.
A total of 74 prostates after radical prostatectomy were used to perform biopsies ex vivo. First, a sextant biopsy was taken, then two different rebiopsy techniques were performed. Rebiopsy technique A consisted of a laterally placed sextant biopsy and two cores per side of the transition zones only. Rebiopsy technique B included a standard sextant biopsy and two cores per side from the lateral areas of the prostate. The biopsies were taken using ultrasound guidance to sample the areas of interest precisely.
The initial sextant biopsy found 39 prostate cancers. Rebiopsy technique A found 12 cancers (34%). In this group, a laterally placed sextant biopsy found 12 cancers; transition zone biopsies revealed cancer in 5 cases, but no additional tumor was found. Rebiopsy technique B detected 23 prostate cancers (66%). Fourteen tumors were found after a second standard sextant biopsy, and nine additional tumors were found in the lateral areas.
Sextant biopsy has a low sensitivity of only 53%. A biopsy including the transition zones is not the ideal technique for detecting the remaining tumors. Therefore, transition zone biopsies should be reserved for patients with multiple previous negative biopsies of the peripheral zone. A subsequent sextant biopsy with additional cores from the lateral areas of the prostate is favorable if rebiopsy is necessary after a negative sextant biopsy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12670559</pmid><doi>10.1016/S0090-4295(02)02502-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Biopsy, Needle - methods Biopsy, Needle - statistics & numerical data False Negative Reactions Genital system. Mammary gland Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Palpation Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prostate - diagnostic imaging Prostate - pathology Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Reoperation Sensitivity and Specificity Ultrasonography |
| title | Evaluation of transition zone and lateral sextant biopsies for prostate cancer detection after initial sextant biopsy |
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