Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1

Lysophosphatidic acid (LPA) is a lipid mediator with diverse effects on various cells. Here, we investigated the effects of LPA on human colon carcinoma DLD1 cells. Northern blot analysis revealed that DLD1 highly expressed LPA1/Edg-2 but showed only low expression of LPA2/Edg-4 and no expression of...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-04, Vol.63 (7), p.1706-1711
Hauptverfasser:	SHIDA, Dai, KITAYAMA, Joji, YAMAGUCHI, Hironori, OKAJI, Yurai, TSUNO, Nelson Hirokazu, WATANABE, Toshiaki, TAKUWA, Yoh, NAGAWA, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Adhesion - drug effects Cell Division - drug effects Cell Movement - drug effects Collagen Type I - metabolism Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - secretion Dissemination Endothelial Growth Factors - secretion Enzyme Activation - drug effects Humans I-kappa B Proteins - metabolism Intercellular Signaling Peptides and Proteins - secretion Interleukin-8 - secretion Lymphokines - secretion Lysophospholipids - pharmacology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 2 - secretion Medical sciences Neoplasm Metastasis NF-KappaB Inhibitor alpha Nuclear Proteins - metabolism Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, G-Protein-Coupled Receptors, Lysophosphatidic Acid RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal Transduction - drug effects Transcription Factors - metabolism Tumor cell Tumors Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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