Functional Analysis of Murine Uterine Natural Killer Cells Genetically Devoid of Oestrogen Receptors

Uterine Natural Killer (uNK) cell differentiation in vivo requires oestrogen (E) priming prior to progesterone (P). Hybridomas between uNK precursor and SP2/0 cells express message for E receptor (ER)α but nor PR. However, mature, rodent and human uNK cells lack these receptors. To functionally asse...

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Veröffentlicht in:	Placenta (Eastbourne) 2003-04, Vol.24 (4), p.403-411
Hauptverfasser:	Borzychowski, A.M, Chantakru, S, Minhas, K, Paffaro, V.A, Yamada, A.T, He, H, Korach, K.S, Croy, B.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow Transplantation Cell Count Cell Differentiation - physiology Cells, Cultured Decidua - blood supply Decidua - cytology Decidua - metabolism Embryo Implantation - physiology Estrogen Receptor alpha Estrogen Receptor beta Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Killer Cells, Natural - metabolism Killer Cells, Natural - ultrastructure Male Mammalian female genital system Mice Mice, Inbred C57BL Mice, Knockout Pregnancy Pregnancy, Animal Receptors, Estrogen - deficiency Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vertebrates: reproduction
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