Interstitial Nephritis Associated with Glomerulonephritis in a Patient with Hashimoto's Disease and Idiopathic Portal Hypertension

A middle-aged woman with hypothyroidism, idiopathic portal hypertension and nephrotic syndrome is presented. This unusual clinical appearance could not be explained as SLE by serological examinations. Pathohistological examinations showed "Banti's liver", Hashimoto's thyroiditis...

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Veröffentlicht in:Internal Medicine 1992, Vol.31(5), pp.641-648
Hauptverfasser: SASAKI, Hidetsugu, JOH, Kensuke, OHTSUKA, Isako, OHTA, Hideki, OHHASHI, Tsutomu, HOASHI, Seiji, TAKAHASHI, Takamune, TOKUDA, Tadaaki, KOYAMA, Katsuichi, ISOGAI, Yukihide
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container_end_page 648
container_issue 5
container_start_page 641
container_title Internal Medicine
container_volume 31
creator SASAKI, Hidetsugu
JOH, Kensuke
OHTSUKA, Isako
OHTA, Hideki
OHHASHI, Tsutomu
HOASHI, Seiji
TAKAHASHI, Takamune
TOKUDA, Tadaaki
KOYAMA, Katsuichi
ISOGAI, Yukihide
description A middle-aged woman with hypothyroidism, idiopathic portal hypertension and nephrotic syndrome is presented. This unusual clinical appearance could not be explained as SLE by serological examinations. Pathohistological examinations showed "Banti's liver", Hashimoto's thyroiditis and diffuse proliferative glomerulonephritis with severe tubulo-interstitial nephritis. Immunohistochemical studies revealed IgA deposits in glomeruli. Electron microscopic study disclosed peculiar lucent areas of rare faction with osmiophilic particles in tubular basement membranes. This tubulointerstitial nephritis was considered to be related to the immunological mechanism involving thyroid gland, liver and kidney disorders. This case thus had a clinically rare combination of these three. (Internal Medicine 31 : 641-648, 1992)
doi_str_mv 10.2169/internalmedicine.31.641
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This unusual clinical appearance could not be explained as SLE by serological examinations. Pathohistological examinations showed "Banti's liver", Hashimoto's thyroiditis and diffuse proliferative glomerulonephritis with severe tubulo-interstitial nephritis. Immunohistochemical studies revealed IgA deposits in glomeruli. Electron microscopic study disclosed peculiar lucent areas of rare faction with osmiophilic particles in tubular basement membranes. This tubulointerstitial nephritis was considered to be related to the immunological mechanism involving thyroid gland, liver and kidney disorders. This case thus had a clinically rare combination of these three. 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JOH, Kensuke ; OHTSUKA, Isako ; OHTA, Hideki ; OHHASHI, Tsutomu ; HOASHI, Seiji ; TAKAHASHI, Takamune ; TOKUDA, Tadaaki ; KOYAMA, Katsuichi ; ISOGAI, Yukihide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4111-bbe920ea1a2a6673fd372afc91f2765d390a2f6a51d4572dd20ac41faf13137e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Female</topic><topic>Glomerulonephritis - complications</topic><topic>Glomerulonephritis - immunology</topic><topic>Glomerulonephritis - pathology</topic><topic>hepatic glomerulosclerosis</topic><topic>Humans</topic><topic>hypergammaglobulinemia</topic><topic>Hypertension, Portal - complications</topic><topic>Hypertension, Portal - pathology</topic><topic>IgA deposits</topic><topic>Immunoglobulin A - metabolism</topic><topic>Kidney Glomerulus - immunology</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Nephritis, Interstitial - complications</topic><topic>Nephritis, Interstitial - pathology</topic><topic>nephrotic syndrome</topic><topic>osmiophilic body</topic><topic>Thyroiditis, Autoimmune - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SASAKI, Hidetsugu</creatorcontrib><creatorcontrib>JOH, Kensuke</creatorcontrib><creatorcontrib>OHTSUKA, Isako</creatorcontrib><creatorcontrib>OHTA, Hideki</creatorcontrib><creatorcontrib>OHHASHI, Tsutomu</creatorcontrib><creatorcontrib>HOASHI, Seiji</creatorcontrib><creatorcontrib>TAKAHASHI, Takamune</creatorcontrib><creatorcontrib>TOKUDA, Tadaaki</creatorcontrib><creatorcontrib>KOYAMA, Katsuichi</creatorcontrib><creatorcontrib>ISOGAI, Yukihide</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SASAKI, Hidetsugu</au><au>JOH, Kensuke</au><au>OHTSUKA, Isako</au><au>OHTA, Hideki</au><au>OHHASHI, Tsutomu</au><au>HOASHI, Seiji</au><au>TAKAHASHI, Takamune</au><au>TOKUDA, Tadaaki</au><au>KOYAMA, Katsuichi</au><au>ISOGAI, Yukihide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interstitial Nephritis Associated with Glomerulonephritis in a Patient with Hashimoto's Disease and Idiopathic Portal Hypertension</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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subjects Female
Glomerulonephritis - complications
Glomerulonephritis - immunology
Glomerulonephritis - pathology
hepatic glomerulosclerosis
Humans
hypergammaglobulinemia
Hypertension, Portal - complications
Hypertension, Portal - pathology
IgA deposits
Immunoglobulin A - metabolism
Kidney Glomerulus - immunology
Microscopy, Electron
Middle Aged
Nephritis, Interstitial - complications
Nephritis, Interstitial - pathology
nephrotic syndrome
osmiophilic body
Thyroiditis, Autoimmune - complications
title Interstitial Nephritis Associated with Glomerulonephritis in a Patient with Hashimoto's Disease and Idiopathic Portal Hypertension
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