Hyperoxia elicits myocardial protection through a nuclear factor kappaB-dependent mechanism in the rat heart

Hyperoxia has been previously shown to protect the heart from ischemia-reperfusion injury. In the present study we investigated whether the cardioprotective effects of hyperoxia were dependent on the redox-sensitive transcription factor nuclear factor kappaB. Rats were kept in a hyperoxic (> or =...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2003-03, Vol.125 (3), p.650-660
Hauptverfasser:	Tähepõld, Peeter, Vaage, Jarle, Starkopf, Joel, Valen, Guro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antioxidants - pharmacology Coronary Circulation Disease Models, Animal Electrophoretic Mobility Shift Assay Hyperoxia - metabolism I-kappa B Proteins - analysis Immunoblotting In Vitro Techniques Ischemic Preconditioning, Myocardial - methods Male Myocardial Contraction Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control NF-kappa B - analysis NF-kappa B - antagonists & inhibitors NF-kappa B - physiology NF-KappaB Inhibitor alpha Oxidation-Reduction Oxygen Inhalation Therapy - methods Peptides - pharmacology Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Recovery of Function Thiocarbamates - pharmacology Time Factors Transcriptional Activation Ventricular Pressure
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