Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor
Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly iden...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1992-08, Vol.257 (5073), p.1089-1095 |
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| container_issue | 5073 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 257 |
| creator | Grueneberg, Dorre A. Natesan, Sridaran Alexandre, Cyrille Gilman, Michael Z. |
| description | Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA resides within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of the specificity of action of homeodomain proteins in development. |
| doi_str_mv | 10.1126/science.257.5073.1089 |
| format | Article |
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How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. 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Psychology ; Fungal Proteins - chemistry ; Fungal Proteins - pharmacology ; HeLa cells ; homeodomain ; Homeodomain Proteins ; Humans ; man ; Minichromosome Maintenance 1 Protein ; Molecular and cellular biology ; Molecular Sequence Data ; Nuclear Proteins - metabolism ; Plasmids ; proteins ; Reporter genes ; Saccharomyces cerevisiae - genetics ; Serum Response Factor ; Transcription Factors - chemistry ; Transcription Factors - metabolism ; Transcription Factors - pharmacology ; Transfection ; Yeasts</subject><ispartof>Science (American Association for the Advancement of Science), 1992-08, Vol.257 (5073), p.1089-1095</ispartof><rights>Copyright 1992 American Association for the Advancement of Science</rights><rights>1992 INIST-CNRS</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c660t-d2b094cd0c67d37235904140d618ad98eebe7d16ce27ec6fed356736634a0df13</citedby><cites>FETCH-LOGICAL-c660t-d2b094cd0c67d37235904140d618ad98eebe7d16ce27ec6fed356736634a0df13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2879837$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2879837$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5472335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1509260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grueneberg, Dorre A.</creatorcontrib><creatorcontrib>Natesan, Sridaran</creatorcontrib><creatorcontrib>Alexandre, Cyrille</creatorcontrib><creatorcontrib>Gilman, Michael Z.</creatorcontrib><title>Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. 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Psychology</subject><subject>Fungal Proteins - chemistry</subject><subject>Fungal Proteins - pharmacology</subject><subject>HeLa cells</subject><subject>homeodomain</subject><subject>Homeodomain Proteins</subject><subject>Humans</subject><subject>man</subject><subject>Minichromosome Maintenance 1 Protein</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - metabolism</subject><subject>Plasmids</subject><subject>proteins</subject><subject>Reporter genes</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Serum Response Factor</subject><subject>Transcription Factors - chemistry</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription Factors - pharmacology</subject><subject>Transfection</subject><subject>Yeasts</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0kFr2zAUwHEzNrqs2zdYQYcxdqgzybIl-5imbVIIzVi7XYUiPScqtpRa8mi_fZUldAQCCz4Y_H6yDu-fJGcEDwnJ2HevDFgFw6zgwwJzOiS4rN4kA4KrIq0yTN8mA4wpS0vMi_fJB-8fMI6zip4kJ6TAVcbwIFlN-1ZaJK1Gl53zbr0yjURT14LTrpXGoh-dC2CsR_crGdCVXcl4KworQJe3o_TCWG3sEo1UMH9MeEauRnfQ9S36CX7trAd0LVVw3cfkXS0bD59279Pk1_XV_XiazuaTm_FolirGcEh1tsBVrjRWjGvKM1pUOCc51oyUUlclwAK4JkxBxkGxGjQtGKeM0VxiXRN6mnzd_nfduccefBCt8QqaRlpwvReckjzntPgvJIxmhJR5hOdbuJQNCGNrFzqplmChk42zUJv4eUSyosw4LiNPD_D4aGiNOuS_7flIAjyFpey9Fzd3t0fT-e-j6cXkWFpOZnv0_BBVrmlgCSIucjzf48WWq5iW76AW6860snsWBItNxGIXsYgRi03EYhNxPHe2W02_aEH_O7WtNs6_7ObSK9nUXUzS-FdW5LGbvxv-vGUPPgb4Os5KXpWU0xc9Qv_m</recordid><startdate>19920821</startdate><enddate>19920821</enddate><creator>Grueneberg, Dorre A.</creator><creator>Natesan, Sridaran</creator><creator>Alexandre, Cyrille</creator><creator>Gilman, Michael Z.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7SS</scope><scope>7T3</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19920821</creationdate><title>Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor</title><author>Grueneberg, Dorre A. ; Natesan, Sridaran ; Alexandre, Cyrille ; Gilman, Michael Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c660t-d2b094cd0c67d37235904140d618ad98eebe7d16ce27ec6fed356736634a0df13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>activity</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>binding</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Cell differentiation</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Cells</topic><topic>Complementary DNA</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>DNA - metabolism</topic><topic>DNA binding proteins</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>DNA-Binding Proteins - pharmacology</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal Proteins - chemistry</topic><topic>Fungal Proteins - pharmacology</topic><topic>HeLa cells</topic><topic>homeodomain</topic><topic>Homeodomain Proteins</topic><topic>Humans</topic><topic>man</topic><topic>Minichromosome Maintenance 1 Protein</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - metabolism</topic><topic>Plasmids</topic><topic>proteins</topic><topic>Reporter genes</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Serum Response Factor</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription Factors - pharmacology</topic><topic>Transfection</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grueneberg, Dorre A.</creatorcontrib><creatorcontrib>Natesan, Sridaran</creatorcontrib><creatorcontrib>Alexandre, Cyrille</creatorcontrib><creatorcontrib>Gilman, Michael Z.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Human Genome Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grueneberg, Dorre A.</au><au>Natesan, Sridaran</au><au>Alexandre, Cyrille</au><au>Gilman, Michael Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1992-08-21</date><risdate>1992</risdate><volume>257</volume><issue>5073</issue><spage>1089</spage><epage>1095</epage><pages>1089-1095</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA resides within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of the specificity of action of homeodomain proteins in development.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>1509260</pmid><doi>10.1126/science.257.5073.1089</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1992-08, Vol.257 (5073), p.1089-1095 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73144735 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | activity Amino Acid Sequence Amino acids Animals Base Sequence binding Binding Sites Biological and medical sciences Cell differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Cells Complementary DNA DNA DNA - genetics DNA - metabolism DNA binding proteins DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - pharmacology Drosophila Drosophila - genetics Drosophila Proteins Fundamental and applied biological sciences. Psychology Fungal Proteins - chemistry Fungal Proteins - pharmacology HeLa cells homeodomain Homeodomain Proteins Humans man Minichromosome Maintenance 1 Protein Molecular and cellular biology Molecular Sequence Data Nuclear Proteins - metabolism Plasmids proteins Reporter genes Saccharomyces cerevisiae - genetics Serum Response Factor Transcription Factors - chemistry Transcription Factors - metabolism Transcription Factors - pharmacology Transfection Yeasts |
| title | Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor |
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