Calcium-activated transient outward chloride current and phase 1 repolarization of swine ventricular action potential

It is unknown whether 4-aminopyridine- (4-AP-) sensitive transient outward K(+) current (I(to1)) and/or Ca(2+)-activated transient outward Cl(-) current (I(Ca.Cl) or I(to2)) contribute(s) to phase 1 repolarization of pig ventricular action potential (AP). The purpose of the present study was to dete...

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Veröffentlicht in:	Cardiovascular research 2003-04, Vol.58 (1), p.89-98
Hauptverfasser:	LI, Gui-Rong, DU, Xin-Ling, SIOW, Yaw L, KARMIN O, TSE, Hung-Fat, LAU, Chu-Pak
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology 4-Aminopyridine - pharmacology Action Potentials - drug effects Action Potentials - physiology Animals Biological and medical sciences Blotting, Western - methods Cadmium - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Chloride Channels - drug effects Chloride Channels - metabolism Fundamental and applied biological sciences. Psychology Heart Heart Ventricles Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Patch-Clamp Techniques Potassium Channel Blockers - pharmacology Potassium Channels - analysis Potassium Channels - metabolism Potassium Channels, Voltage-Gated Ryanodine - pharmacology Shal Potassium Channels Swine Vertebrates: cardiovascular system
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