Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase

In search of novel nonsteroidal mimics of steroidal inhibitors of 5α reductase, 4‐(2‐phenylethyl)cyclohex‐1‐ene carboxylic acids 1—5 were synthesized with different substituents in para position of the phenyl ring (1: N, N‐diisopropylcarbamoyl, 2: phenyl, 3: phenoxy, 4: benzoyl, and 5: benzyl). The...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2003-03, Vol.336 (1), p.31-38
Hauptverfasser:	Baston, Eckhard, Salem, Ola I. A., Hartmann, Rolf W.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Benign prostatic hyperplasia Biological and medical sciences Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Carboxylic Acids - pharmacology Chromatography, High Pressure Liquid Cyclohex-1-ene carboxylic acids DU 145 cells Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Isoenzymes - drug effects Isozymes 1 and 2 Male Medical sciences Nonsteroidal inhibitors Pharmacology. Drug treatments Steroid 5α reductase Steroidomimetics Structure-Activity Relationship Urinary system
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