Comparing event-related and epoch analysis in blocked design fMRI
In this study we demonstrate that, even in blocked design fMRI, an event-related analysis may provide a more accurate model of the hemodynamic responses than an epoch-related analysis. This is because the temporal shape of the predicted response differs between the event-related and the epoch model,...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2003-03, Vol.18 (3), p.806-810 |
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| creator | Mechelli, Andrea Henson, Rik N.A Price, Cathy J Friston, Karl J |
| description | In this study we demonstrate that, even in blocked design fMRI, an event-related analysis may provide a more accurate model of the hemodynamic responses than an epoch-related analysis. This is because the temporal shape of the predicted response differs between the event-related and the epoch model, with the former reaching its peak sooner and returning to baseline later than the latter. We present data from a blocked design fMRI study of single word reading alternated with rest. Conventionally, such a design would be analyzed using an epoch analysis with boxcar regressors. However, here we used a combined model in which trials were modeled as both single events and epochs. This allowed us to estimate the variance in the BOLD signal that was explained by either the event-related or the epoch regressors having discounted the effect of the other. We found that, in a number of language regions, the event-related model explained changes in activity that were not accounted for by the epoch model. In addition, we show that the advantage of the event-related over epoch model was engendered by its early onset rather than its late offset, relative to the epoch model. |
| doi_str_mv | 10.1016/S1053-8119(02)00027-7 |
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| subjects | Adult Attention - physiology Brain Mapping Cerebral Cortex - physiology Female Hemodynamics - physiology Humans Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Male Mathematical Computing Medical research Neurons - physiology NMR Nuclear magnetic resonance Pattern Recognition, Visual - physiology Reaction Time - physiology Reading Regression Analysis Research Design Sensitivity and Specificity Vision systems |
| title | Comparing event-related and epoch analysis in blocked design fMRI |
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