Region-specific immunological response of the different laryngeal compartments: significance of larynx-associated lymphoid tissue
The occurrence of primary extranodal marginal-zone B-cell lymphoma [of the mucosa-associated lymphoid tissue (MALT) type] has only been described in the supraglottic region, implying that preexistent organized lymphoid tissue is present at that site only. To date, studies have not established clearl...
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| Veröffentlicht in: | Cell and tissue research 2003-03, Vol.311 (3), p.365-371 |
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| creator | Kutta, Hannes Steven, Philipp Tillmann, Bernhard N Tsokos, Michael Paulsen, Friedrich P |
| description | The occurrence of primary extranodal marginal-zone B-cell lymphoma [of the mucosa-associated lymphoid tissue (MALT) type] has only been described in the supraglottic region, implying that preexistent organized lymphoid tissue is present at that site only. To date, studies have not established clearly whether organized MALT shows a site-related distribution in the larynx. The supraglottic region of the false vocal folds and the subglottis from 87 unselected cadavers with no known history of nasal, oral, pharyngeal, laryngeal, tracheal, or esophageal disease were examined for the presence of organized MALT. Organized lymphoid tissue was found with the cytomorphological and immunophenotypic features of MALT in 100% of false vocal folds of children and in more than 90% of adolescents, decreasing to 7.1% in persons in their sixth decade, whereas MALT was completely absent in the subglottis in all age groups. The results explain why primary extranodal marginal-zone B-cell lymphoma has only been described in the supraglottic region but is absent in the subglottis. Moreover, the results suggest a region-specific immunological response of the different laryngeal areas as reflected in clinical observations and animal studies. However, the impact on presence or absence of laryngeal MALT awaits clarification. |
| doi_str_mv | 10.1007/s00441-002-0692-y |
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To date, studies have not established clearly whether organized MALT shows a site-related distribution in the larynx. The supraglottic region of the false vocal folds and the subglottis from 87 unselected cadavers with no known history of nasal, oral, pharyngeal, laryngeal, tracheal, or esophageal disease were examined for the presence of organized MALT. Organized lymphoid tissue was found with the cytomorphological and immunophenotypic features of MALT in 100% of false vocal folds of children and in more than 90% of adolescents, decreasing to 7.1% in persons in their sixth decade, whereas MALT was completely absent in the subglottis in all age groups. The results explain why primary extranodal marginal-zone B-cell lymphoma has only been described in the supraglottic region but is absent in the subglottis. Moreover, the results suggest a region-specific immunological response of the different laryngeal areas as reflected in clinical observations and animal studies. However, the impact on presence or absence of laryngeal MALT awaits clarification.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-002-0692-y</identifier><identifier>PMID: 12658444</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Dendritic Cells - cytology ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Female ; Fetus ; Humans ; Immunity, Mucosal - immunology ; Immunoglobulin A - metabolism ; Immunohistochemistry ; Infant ; Infant, Newborn ; Laryngeal Mucosa - cytology ; Laryngeal Mucosa - immunology ; Laryngeal Mucosa - metabolism ; Laryngitis - immunology ; Laryngitis - pathology ; Laryngitis - physiopathology ; Lymphocytes - cytology ; Lymphocytes - immunology ; Lymphocytes - metabolism ; Lymphoid Tissue - cytology ; Lymphoid Tissue - immunology ; Lymphoid Tissue - metabolism ; Lymphoma, B-Cell, Marginal Zone - immunology ; Lymphoma, B-Cell, Marginal Zone - pathology ; Lymphoma, B-Cell, Marginal Zone - physiopathology ; Macrophages - cytology ; Macrophages - immunology ; Macrophages - metabolism ; Male ; Middle Aged ; Pregnancy ; Sex Factors ; Vocal Cords - cytology ; Vocal Cords - immunology ; Vocal Cords - metabolism</subject><ispartof>Cell and tissue research, 2003-03, Vol.311 (3), p.365-371</ispartof><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-56fe7b4a7649171557826689e232dd03f4b6eedaa03ad27486721a89d62667f83</citedby><cites>FETCH-LOGICAL-c324t-56fe7b4a7649171557826689e232dd03f4b6eedaa03ad27486721a89d62667f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12658444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kutta, Hannes</creatorcontrib><creatorcontrib>Steven, Philipp</creatorcontrib><creatorcontrib>Tillmann, Bernhard N</creatorcontrib><creatorcontrib>Tsokos, Michael</creatorcontrib><creatorcontrib>Paulsen, Friedrich P</creatorcontrib><title>Region-specific immunological response of the different laryngeal compartments: significance of larynx-associated lymphoid tissue</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><description>The occurrence of primary extranodal marginal-zone B-cell lymphoma [of the mucosa-associated lymphoid tissue (MALT) type] has only been described in the supraglottic region, implying that preexistent organized lymphoid tissue is present at that site only. To date, studies have not established clearly whether organized MALT shows a site-related distribution in the larynx. The supraglottic region of the false vocal folds and the subglottis from 87 unselected cadavers with no known history of nasal, oral, pharyngeal, laryngeal, tracheal, or esophageal disease were examined for the presence of organized MALT. Organized lymphoid tissue was found with the cytomorphological and immunophenotypic features of MALT in 100% of false vocal folds of children and in more than 90% of adolescents, decreasing to 7.1% in persons in their sixth decade, whereas MALT was completely absent in the subglottis in all age groups. The results explain why primary extranodal marginal-zone B-cell lymphoma has only been described in the supraglottic region but is absent in the subglottis. Moreover, the results suggest a region-specific immunological response of the different laryngeal areas as reflected in clinical observations and animal studies. However, the impact on presence or absence of laryngeal MALT awaits clarification.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Female</subject><subject>Fetus</subject><subject>Humans</subject><subject>Immunity, Mucosal - immunology</subject><subject>Immunoglobulin A - metabolism</subject><subject>Immunohistochemistry</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Laryngeal Mucosa - cytology</subject><subject>Laryngeal Mucosa - immunology</subject><subject>Laryngeal Mucosa - metabolism</subject><subject>Laryngitis - immunology</subject><subject>Laryngitis - pathology</subject><subject>Laryngitis - physiopathology</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphoid Tissue - metabolism</subject><subject>Lymphoma, B-Cell, Marginal Zone - immunology</subject><subject>Lymphoma, B-Cell, Marginal Zone - pathology</subject><subject>Lymphoma, B-Cell, Marginal Zone - physiopathology</subject><subject>Macrophages - cytology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>Sex Factors</subject><subject>Vocal Cords - cytology</subject><subject>Vocal Cords - immunology</subject><subject>Vocal Cords - metabolism</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU9rFDEYh4Modlv9AF4kePA2Nv8myXiTolYoFKSCt5BN3mxTZpIxmYHusd_cbHdB8BTevM_vR8KD0DtKPlFC1GUlRAjaEcI6IgfW7V-gDRW8TVrpl2hDeNsoKX-fofNaHwihQsrhNTqjTPZaCLFBTz9hF3Pq6gwuhuhwnKY15THvorMjLlDnnCrgHPByD9jHEKBAWvBoyz7toDEuT7Mty9Ru62dc4y4dimxyz6ln7rGztWYX7QIej_tpvs_R4yXWusIb9CrYscLb03mBfn37end13d3cfv9x9eWmc5yJpetlALUVVkkxUEX7XmkmpR6AceY94UFsJYC3lnDrmRJaKkatHrxsmAqaX6CPx9655D8r1MVMsToYR5sgr9UoTgXV9AB--A98yGtJ7W2GUa563g-iQfQIuZJrLRDMXOLU_mooMQc55ijHNDnmIMfsW-b9qXjdTuD_JU42-F-6eI0B</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>Kutta, Hannes</creator><creator>Steven, Philipp</creator><creator>Tillmann, Bernhard N</creator><creator>Tsokos, Michael</creator><creator>Paulsen, Friedrich P</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Region-specific immunological response of the different laryngeal compartments: significance of larynx-associated lymphoid tissue</title><author>Kutta, Hannes ; Steven, Philipp ; Tillmann, Bernhard N ; Tsokos, Michael ; Paulsen, Friedrich P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-56fe7b4a7649171557826689e232dd03f4b6eedaa03ad27486721a89d62667f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dendritic Cells - cytology</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Female</topic><topic>Fetus</topic><topic>Humans</topic><topic>Immunity, Mucosal - immunology</topic><topic>Immunoglobulin A - metabolism</topic><topic>Immunohistochemistry</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Laryngeal Mucosa - cytology</topic><topic>Laryngeal Mucosa - immunology</topic><topic>Laryngeal Mucosa - metabolism</topic><topic>Laryngitis - immunology</topic><topic>Laryngitis - pathology</topic><topic>Laryngitis - physiopathology</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphoid Tissue - cytology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Lymphoid Tissue - metabolism</topic><topic>Lymphoma, B-Cell, Marginal Zone - immunology</topic><topic>Lymphoma, B-Cell, Marginal Zone - pathology</topic><topic>Lymphoma, B-Cell, Marginal Zone - physiopathology</topic><topic>Macrophages - 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Academic</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kutta, Hannes</au><au>Steven, Philipp</au><au>Tillmann, Bernhard N</au><au>Tsokos, Michael</au><au>Paulsen, Friedrich P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Region-specific immunological response of the different laryngeal compartments: significance of larynx-associated lymphoid tissue</atitle><jtitle>Cell and tissue research</jtitle><addtitle>Cell Tissue Res</addtitle><date>2003-03</date><risdate>2003</risdate><volume>311</volume><issue>3</issue><spage>365</spage><epage>371</epage><pages>365-371</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>The occurrence of primary extranodal marginal-zone B-cell lymphoma [of the mucosa-associated lymphoid tissue (MALT) type] has only been described in the supraglottic region, implying that preexistent organized lymphoid tissue is present at that site only. To date, studies have not established clearly whether organized MALT shows a site-related distribution in the larynx. The supraglottic region of the false vocal folds and the subglottis from 87 unselected cadavers with no known history of nasal, oral, pharyngeal, laryngeal, tracheal, or esophageal disease were examined for the presence of organized MALT. Organized lymphoid tissue was found with the cytomorphological and immunophenotypic features of MALT in 100% of false vocal folds of children and in more than 90% of adolescents, decreasing to 7.1% in persons in their sixth decade, whereas MALT was completely absent in the subglottis in all age groups. The results explain why primary extranodal marginal-zone B-cell lymphoma has only been described in the supraglottic region but is absent in the subglottis. Moreover, the results suggest a region-specific immunological response of the different laryngeal areas as reflected in clinical observations and animal studies. However, the impact on presence or absence of laryngeal MALT awaits clarification.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>12658444</pmid><doi>10.1007/s00441-002-0692-y</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Child Child, Preschool Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Female Fetus Humans Immunity, Mucosal - immunology Immunoglobulin A - metabolism Immunohistochemistry Infant Infant, Newborn Laryngeal Mucosa - cytology Laryngeal Mucosa - immunology Laryngeal Mucosa - metabolism Laryngitis - immunology Laryngitis - pathology Laryngitis - physiopathology Lymphocytes - cytology Lymphocytes - immunology Lymphocytes - metabolism Lymphoid Tissue - cytology Lymphoid Tissue - immunology Lymphoid Tissue - metabolism Lymphoma, B-Cell, Marginal Zone - immunology Lymphoma, B-Cell, Marginal Zone - pathology Lymphoma, B-Cell, Marginal Zone - physiopathology Macrophages - cytology Macrophages - immunology Macrophages - metabolism Male Middle Aged Pregnancy Sex Factors Vocal Cords - cytology Vocal Cords - immunology Vocal Cords - metabolism |
| title | Region-specific immunological response of the different laryngeal compartments: significance of larynx-associated lymphoid tissue |
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