Refractive Errors, Axial Ocular Dimensions, and Age-Related Cataracts: The Tanjong Pagar Survey
To describe the relationship of refractive errors and axial ocular dimensions and age-related cataract. Population-based, cross-sectional survey of ocular diseases among Chinese men and women aged 40 to 81 years (n = 1232) living in the Tanjong Pagar district in Singapore. As part of the examination...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2003-04, Vol.44 (4), p.1479-1485 |
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| creator | Wong, Tien Yin Foster, Paul J Johnson, Gordon J Seah, Steve K. L |
| description | To describe the relationship of refractive errors and axial ocular dimensions and age-related cataract.
Population-based, cross-sectional survey of ocular diseases among Chinese men and women aged 40 to 81 years (n = 1232) living in the Tanjong Pagar district in Singapore. As part of the examination, refraction and corneal curvature were determined with an autorefractor, with refraction further refined subjectively. Ocular dimensions, including axial length, anterior chamber depth, lens thickness, and vitreous chamber depth, were measured with an A-mode ultrasound device. Lens opacity was graded clinically according to the Lens Opacity Classification System (LOCS) III system. Refraction, biometry, and cataract data on right (n = 989) and left (n = 995) eyes were analyzed separately.
In analyses controlling for age, gender, education, diabetes, and cigarette smoking, nuclear cataract was associated with myopia (-1.35 D vs. -0.11 D, P < 0.001, comparing right eyes with and without nuclear cataract), but not with any specific biometric component. Cortical cataract was associated with thinner lenses (4.67 mm vs. 4.79 mm, P = 0.001, comparing right eyes with and without cortical cataract), but not with refraction and other biometric components. Posterior subcapsular cataract was associated with myopia (-1.80 D vs. -0.39 D, P < 0.001, comparing right eyes with and without posterior subcapsular cataract), deeper anterior chamber (3.00 mm vs. 2.89 mm, P = 0.02), thinner lens (4.62 mm vs. 4.77 mm, P = 0.001), and longer vitreous chamber (15.78 mm vs. 15.57 mm, P = 0.09), but not with overall axial length and corneal curvature. Adjustment for vitreous chamber depth attenuated the association between posterior subcapsular cataract and myopia by 65.5%, but did not substantially change the association between nuclear cataract and myopia.
These population-based data support the associations between nuclear and posterior subcapsular cataracts and myopia reported in previous studies. Posterior subcapsular cataract is also associated with deeper anterior chamber, thinner lens, and longer vitreous chamber, with vitreous chamber depth explaining most of the association between posterior subcapsular cataract and myopia. |
| doi_str_mv | 10.1167/iovs.02-0526 |
| format | Article |
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Population-based, cross-sectional survey of ocular diseases among Chinese men and women aged 40 to 81 years (n = 1232) living in the Tanjong Pagar district in Singapore. As part of the examination, refraction and corneal curvature were determined with an autorefractor, with refraction further refined subjectively. Ocular dimensions, including axial length, anterior chamber depth, lens thickness, and vitreous chamber depth, were measured with an A-mode ultrasound device. Lens opacity was graded clinically according to the Lens Opacity Classification System (LOCS) III system. Refraction, biometry, and cataract data on right (n = 989) and left (n = 995) eyes were analyzed separately.
In analyses controlling for age, gender, education, diabetes, and cigarette smoking, nuclear cataract was associated with myopia (-1.35 D vs. -0.11 D, P < 0.001, comparing right eyes with and without nuclear cataract), but not with any specific biometric component. Cortical cataract was associated with thinner lenses (4.67 mm vs. 4.79 mm, P = 0.001, comparing right eyes with and without cortical cataract), but not with refraction and other biometric components. Posterior subcapsular cataract was associated with myopia (-1.80 D vs. -0.39 D, P < 0.001, comparing right eyes with and without posterior subcapsular cataract), deeper anterior chamber (3.00 mm vs. 2.89 mm, P = 0.02), thinner lens (4.62 mm vs. 4.77 mm, P = 0.001), and longer vitreous chamber (15.78 mm vs. 15.57 mm, P = 0.09), but not with overall axial length and corneal curvature. Adjustment for vitreous chamber depth attenuated the association between posterior subcapsular cataract and myopia by 65.5%, but did not substantially change the association between nuclear cataract and myopia.
These population-based data support the associations between nuclear and posterior subcapsular cataracts and myopia reported in previous studies. Posterior subcapsular cataract is also associated with deeper anterior chamber, thinner lens, and longer vitreous chamber, with vitreous chamber depth explaining most of the association between posterior subcapsular cataract and myopia.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.02-0526</identifier><identifier>PMID: 12657582</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging - physiology ; Asian Continental Ancestry Group ; Biological and medical sciences ; Biometry ; Cataract - ethnology ; Cataract - physiopathology ; Cross-Sectional Studies ; Eye - anatomy & histology ; Female ; Health Surveys ; Humans ; Lens diseases ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Refraction, Ocular - physiology ; Refractive Errors - ethnology ; Refractive Errors - physiopathology ; Retinopathies ; Singapore - epidemiology ; Vision disorders ; Weights and Measures</subject><ispartof>Investigative ophthalmology & visual science, 2003-04, Vol.44 (4), p.1479-1485</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1e84670fd610ca07a250a1042075e4f56a288b24597eb23a969b2df55412791b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14684839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12657582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Tien Yin</creatorcontrib><creatorcontrib>Foster, Paul J</creatorcontrib><creatorcontrib>Johnson, Gordon J</creatorcontrib><creatorcontrib>Seah, Steve K. L</creatorcontrib><title>Refractive Errors, Axial Ocular Dimensions, and Age-Related Cataracts: The Tanjong Pagar Survey</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To describe the relationship of refractive errors and axial ocular dimensions and age-related cataract.
Population-based, cross-sectional survey of ocular diseases among Chinese men and women aged 40 to 81 years (n = 1232) living in the Tanjong Pagar district in Singapore. As part of the examination, refraction and corneal curvature were determined with an autorefractor, with refraction further refined subjectively. Ocular dimensions, including axial length, anterior chamber depth, lens thickness, and vitreous chamber depth, were measured with an A-mode ultrasound device. Lens opacity was graded clinically according to the Lens Opacity Classification System (LOCS) III system. Refraction, biometry, and cataract data on right (n = 989) and left (n = 995) eyes were analyzed separately.
In analyses controlling for age, gender, education, diabetes, and cigarette smoking, nuclear cataract was associated with myopia (-1.35 D vs. -0.11 D, P < 0.001, comparing right eyes with and without nuclear cataract), but not with any specific biometric component. Cortical cataract was associated with thinner lenses (4.67 mm vs. 4.79 mm, P = 0.001, comparing right eyes with and without cortical cataract), but not with refraction and other biometric components. Posterior subcapsular cataract was associated with myopia (-1.80 D vs. -0.39 D, P < 0.001, comparing right eyes with and without posterior subcapsular cataract), deeper anterior chamber (3.00 mm vs. 2.89 mm, P = 0.02), thinner lens (4.62 mm vs. 4.77 mm, P = 0.001), and longer vitreous chamber (15.78 mm vs. 15.57 mm, P = 0.09), but not with overall axial length and corneal curvature. Adjustment for vitreous chamber depth attenuated the association between posterior subcapsular cataract and myopia by 65.5%, but did not substantially change the association between nuclear cataract and myopia.
These population-based data support the associations between nuclear and posterior subcapsular cataracts and myopia reported in previous studies. Posterior subcapsular cataract is also associated with deeper anterior chamber, thinner lens, and longer vitreous chamber, with vitreous chamber depth explaining most of the association between posterior subcapsular cataract and myopia.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Biometry</subject><subject>Cataract - ethnology</subject><subject>Cataract - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Eye - anatomy & histology</subject><subject>Female</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Lens diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Refraction, Ocular - physiology</subject><subject>Refractive Errors - ethnology</subject><subject>Refractive Errors - physiopathology</subject><subject>Retinopathies</subject><subject>Singapore - epidemiology</subject><subject>Vision disorders</subject><subject>Weights and Measures</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtu2zAQRYmiQeMm3XVdcNOuooRD8SF1Z7jpAwiQIHXXxEga2QwoKSUlu_n7yogBr2Zxz70YHMY-grgGMPbGD7t0LWQmtDRv2AK0lpm2Rf6WLQQokwkl1Dl7n9KTEBJAinfsHKTRVhdywdwjtRHr0e-I38Y4xHTFl_88Bn5fTwEj_-Y76pMf-jnAvuHLDWWPFHCkhq9wxEM5feXrLfE19k9Dv-EPuJmLv6e4o5dLdtZiSPTheC_Yn--369XP7O7-x6_V8i6r88KMGVChjBVtY0DUKCxKLRCEksJqUq02KIuikkqXliqZY2nKSjat1gqkLaHKL9iX193nOPydKI2u86mmELCnYUrO5qBAWTODV69gHYeUIrXuOfoO44sD4Q5C3UGoE9IdhM74p-PuVHXUnOCjwRn4fAQw1RhmmX3t04lTplBFXp4e3PrNdu8judRhCPMsuP1-r5RTM2zL_D_Yfonr</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Wong, Tien Yin</creator><creator>Foster, Paul J</creator><creator>Johnson, Gordon J</creator><creator>Seah, Steve K. L</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Refractive Errors, Axial Ocular Dimensions, and Age-Related Cataracts: The Tanjong Pagar Survey</title><author>Wong, Tien Yin ; Foster, Paul J ; Johnson, Gordon J ; Seah, Steve K. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-1e84670fd610ca07a250a1042075e4f56a288b24597eb23a969b2df55412791b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Biometry</topic><topic>Cataract - ethnology</topic><topic>Cataract - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Eye - anatomy & histology</topic><topic>Female</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Lens diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Refraction, Ocular - physiology</topic><topic>Refractive Errors - ethnology</topic><topic>Refractive Errors - physiopathology</topic><topic>Retinopathies</topic><topic>Singapore - epidemiology</topic><topic>Vision disorders</topic><topic>Weights and Measures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Tien Yin</creatorcontrib><creatorcontrib>Foster, Paul J</creatorcontrib><creatorcontrib>Johnson, Gordon J</creatorcontrib><creatorcontrib>Seah, Steve K. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Tien Yin</au><au>Foster, Paul J</au><au>Johnson, Gordon J</au><au>Seah, Steve K. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Refractive Errors, Axial Ocular Dimensions, and Age-Related Cataracts: The Tanjong Pagar Survey</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>44</volume><issue>4</issue><spage>1479</spage><epage>1485</epage><pages>1479-1485</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To describe the relationship of refractive errors and axial ocular dimensions and age-related cataract.
Population-based, cross-sectional survey of ocular diseases among Chinese men and women aged 40 to 81 years (n = 1232) living in the Tanjong Pagar district in Singapore. As part of the examination, refraction and corneal curvature were determined with an autorefractor, with refraction further refined subjectively. Ocular dimensions, including axial length, anterior chamber depth, lens thickness, and vitreous chamber depth, were measured with an A-mode ultrasound device. Lens opacity was graded clinically according to the Lens Opacity Classification System (LOCS) III system. Refraction, biometry, and cataract data on right (n = 989) and left (n = 995) eyes were analyzed separately.
In analyses controlling for age, gender, education, diabetes, and cigarette smoking, nuclear cataract was associated with myopia (-1.35 D vs. -0.11 D, P < 0.001, comparing right eyes with and without nuclear cataract), but not with any specific biometric component. Cortical cataract was associated with thinner lenses (4.67 mm vs. 4.79 mm, P = 0.001, comparing right eyes with and without cortical cataract), but not with refraction and other biometric components. Posterior subcapsular cataract was associated with myopia (-1.80 D vs. -0.39 D, P < 0.001, comparing right eyes with and without posterior subcapsular cataract), deeper anterior chamber (3.00 mm vs. 2.89 mm, P = 0.02), thinner lens (4.62 mm vs. 4.77 mm, P = 0.001), and longer vitreous chamber (15.78 mm vs. 15.57 mm, P = 0.09), but not with overall axial length and corneal curvature. Adjustment for vitreous chamber depth attenuated the association between posterior subcapsular cataract and myopia by 65.5%, but did not substantially change the association between nuclear cataract and myopia.
These population-based data support the associations between nuclear and posterior subcapsular cataracts and myopia reported in previous studies. Posterior subcapsular cataract is also associated with deeper anterior chamber, thinner lens, and longer vitreous chamber, with vitreous chamber depth explaining most of the association between posterior subcapsular cataract and myopia.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>12657582</pmid><doi>10.1167/iovs.02-0526</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Investigative ophthalmology & visual science, 2003-04, Vol.44 (4), p.1479-1485 |
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| subjects | Adult Aged Aged, 80 and over Aging - physiology Asian Continental Ancestry Group Biological and medical sciences Biometry Cataract - ethnology Cataract - physiopathology Cross-Sectional Studies Eye - anatomy & histology Female Health Surveys Humans Lens diseases Male Medical sciences Middle Aged Ophthalmology Refraction, Ocular - physiology Refractive Errors - ethnology Refractive Errors - physiopathology Retinopathies Singapore - epidemiology Vision disorders Weights and Measures |
| title | Refractive Errors, Axial Ocular Dimensions, and Age-Related Cataracts: The Tanjong Pagar Survey |
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