γ-aminobutyric acid, through GABAA receptors, inhibits the potassium-stimulated release of calcitonin gene-related peptide-but not that of substance P-like material from rat spinal cord slices
Superfusion of slices of the dorsal zone of the lumbar enlargement with an artificial cerebrospinal fluid was used to investigate the possible modulation by GABA receptor ligands of the in vitro release of calcitonin gene-related peptide- and substance P-like materials (CGRPLM and SPLM) from the rat...
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| Veröffentlicht in: | Brain research 1992-06, Vol.583 (1-2), p.344-348 |
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| container_title | Brain research |
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| creator | BOURGOIN, S POHL, M BENOLIEL, J. J MAUBORGNE, A COLLIN, E HAMON, M CESSELIN, F |
| description | Superfusion of slices of the dorsal zone of the lumbar enlargement with an artificial cerebrospinal fluid was used to investigate the possible modulation by GABA receptor ligands of the in vitro release of calcitonin gene-related peptide- and substance P-like materials (CGRPLM and SPLM) from the rat spinal cord. Whereas the spontaneous outflow of both peptides remained unaffected, the K+ (30 mM)-evoked overflow of CGRPLM could be partially inhibited (approx. -30%) by GABA (1 microM-0.1 mM) and muscimol (10 microM-0.1 mM) but not by baclofen (1-10 microM). Bicuculline methiodide (1 microM) completely prevented the inhibition by GABA (1 microM) and muscimol (10 microM) as expected from an action through GABAA receptors. By contrast, the K(+)-evoked SPLM overflow was altered neither by GABA nor muscimol and baclofen. These data further support that GABA exerts a presynaptic inhibitory control of (CGRP-containing) primary afferent fibres within the rat dorsal horn. |
| doi_str_mv | 10.1016/S0006-8993(10)80048-4 |
| format | Article |
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By contrast, the K(+)-evoked SPLM overflow was altered neither by GABA nor muscimol and baclofen. These data further support that GABA exerts a presynaptic inhibitory control of (CGRP-containing) primary afferent fibres within the rat dorsal horn.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(10)80048-4</identifier><identifier>PMID: 1380400</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier</publisher><subject>Animals ; Baclofen - pharmacology ; Bicuculline - pharmacology ; Biological and medical sciences ; Calcitonin Gene-Related Peptide - metabolism ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - pharmacology ; In Vitro Techniques ; Male ; Muscimol - pharmacology ; Potassium - pharmacology ; Rats ; Rats, Inbred Strains ; Receptors, GABA-A - drug effects ; Receptors, GABA-A - physiology ; Spinal Cord - drug effects ; Spinal Cord - physiology ; Substance P - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1992-06, Vol.583 (1-2), p.344-348</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c248t-4d7200d2481f1b0e6eccbf4bcc6327fa356c798149497319c9158e45ed5396ed3</citedby><cites>FETCH-LOGICAL-c248t-4d7200d2481f1b0e6eccbf4bcc6327fa356c798149497319c9158e45ed5396ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5361099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1380400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOURGOIN, S</creatorcontrib><creatorcontrib>POHL, M</creatorcontrib><creatorcontrib>BENOLIEL, J. 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Whereas the spontaneous outflow of both peptides remained unaffected, the K+ (30 mM)-evoked overflow of CGRPLM could be partially inhibited (approx. -30%) by GABA (1 microM-0.1 mM) and muscimol (10 microM-0.1 mM) but not by baclofen (1-10 microM). Bicuculline methiodide (1 microM) completely prevented the inhibition by GABA (1 microM) and muscimol (10 microM) as expected from an action through GABAA receptors. By contrast, the K(+)-evoked SPLM overflow was altered neither by GABA nor muscimol and baclofen. These data further support that GABA exerts a presynaptic inhibitory control of (CGRP-containing) primary afferent fibres within the rat dorsal horn.</description><subject>Animals</subject><subject>Baclofen - pharmacology</subject><subject>Bicuculline - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Calcitonin Gene-Related Peptide - metabolism</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscimol - pharmacology</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Receptors, GABA-A - physiology</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - physiology</subject><subject>Substance P - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1TAQhS0EKpfCI1TyAiGQarBj58fL2woKUiWQgHXkOJNeQxIHj7Poc_EEvADPxNwflZU9c745I81h7ELJt0qq6t1XKWUlGmv1ayXfNFKaRphHbKOauhBVYeRjtnlAnrJniD-o1NrKM3amdCONlBv25-9v4aYwx27N9yl47nzoL3nepbje7fjN9mq75Qk8LDkmvORh3oUuZCQC-BKzQwzrJDCHaR1dhp7gERwCjwP3bvQhxznM_A5mECQdkIXcQg-CdvI5ZvJyec_j2mF2swf-RYzhJ_CJ8BTcyIcUJ56IwiXMVPuYeo5j8IDP2ZPBjQgvTu85-_7h_bfrj-L2882n6-2t8IVpsjB9XUjZ018NqpNQgffdYDrvK13Ug9Nl5WvbKGONrbWy3qqyAVNCX2pbQa_P2auj75LirxUwt1NAD-PoZogrtjRk6KyWwPII-hQREwztksLk0n2rZLuPrj1E1-5z2bcO0bWG5i5OC9Zugv7_1DEr0l-edId02SHRpQI-YKWulCTLf75VpcE</recordid><startdate>19920626</startdate><enddate>19920626</enddate><creator>BOURGOIN, S</creator><creator>POHL, M</creator><creator>BENOLIEL, J. 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J ; MAUBORGNE, A ; COLLIN, E ; HAMON, M ; CESSELIN, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c248t-4d7200d2481f1b0e6eccbf4bcc6327fa356c798149497319c9158e45ed5396ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Baclofen - pharmacology</topic><topic>Bicuculline - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Calcitonin Gene-Related Peptide - metabolism</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscimol - pharmacology</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, GABA-A - physiology</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - physiology</topic><topic>Substance P - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOURGOIN, S</creatorcontrib><creatorcontrib>POHL, M</creatorcontrib><creatorcontrib>BENOLIEL, J. J</creatorcontrib><creatorcontrib>MAUBORGNE, A</creatorcontrib><creatorcontrib>COLLIN, E</creatorcontrib><creatorcontrib>HAMON, M</creatorcontrib><creatorcontrib>CESSELIN, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOURGOIN, S</au><au>POHL, M</au><au>BENOLIEL, J. J</au><au>MAUBORGNE, A</au><au>COLLIN, E</au><au>HAMON, M</au><au>CESSELIN, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>γ-aminobutyric acid, through GABAA receptors, inhibits the potassium-stimulated release of calcitonin gene-related peptide-but not that of substance P-like material from rat spinal cord slices</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1992-06-26</date><risdate>1992</risdate><volume>583</volume><issue>1-2</issue><spage>344</spage><epage>348</epage><pages>344-348</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Superfusion of slices of the dorsal zone of the lumbar enlargement with an artificial cerebrospinal fluid was used to investigate the possible modulation by GABA receptor ligands of the in vitro release of calcitonin gene-related peptide- and substance P-like materials (CGRPLM and SPLM) from the rat spinal cord. Whereas the spontaneous outflow of both peptides remained unaffected, the K+ (30 mM)-evoked overflow of CGRPLM could be partially inhibited (approx. -30%) by GABA (1 microM-0.1 mM) and muscimol (10 microM-0.1 mM) but not by baclofen (1-10 microM). Bicuculline methiodide (1 microM) completely prevented the inhibition by GABA (1 microM) and muscimol (10 microM) as expected from an action through GABAA receptors. By contrast, the K(+)-evoked SPLM overflow was altered neither by GABA nor muscimol and baclofen. These data further support that GABA exerts a presynaptic inhibitory control of (CGRP-containing) primary afferent fibres within the rat dorsal horn.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier</pub><pmid>1380400</pmid><doi>10.1016/S0006-8993(10)80048-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Brain research, 1992-06, Vol.583 (1-2), p.344-348 |
| issn | 0006-8993 1872-6240 |
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| subjects | Animals Baclofen - pharmacology Bicuculline - pharmacology Biological and medical sciences Calcitonin Gene-Related Peptide - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - pharmacology In Vitro Techniques Male Muscimol - pharmacology Potassium - pharmacology Rats Rats, Inbred Strains Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Spinal Cord - drug effects Spinal Cord - physiology Substance P - metabolism Vertebrates: nervous system and sense organs |
| title | γ-aminobutyric acid, through GABAA receptors, inhibits the potassium-stimulated release of calcitonin gene-related peptide-but not that of substance P-like material from rat spinal cord slices |
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