Structure and function of archaeal box C/D sRNP core proteins
Nop56p and Nop58p are two core proteins of the box C/D snoRNPs that interact concurrently with fibrillarin and snoRNAs to function in enzyme assembly and catalysis. Here we report the 2.9 Å resolution co-crystal structure of an archaeal homolog of Nop56p/Nop58p, Nop5p, in complex with fibrillarin fr...
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| Veröffentlicht in: | Nature Structural Biology 2003-04, Vol.10 (4), p.256-263 |
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| creator | Aittaleb, Mohamed Rashid, Rumana Chen, Qiong Palmer, John R. Daniels, Charles J. Li, Hong |
| description | Nop56p and Nop58p are two core proteins of the box C/D snoRNPs that interact concurrently with fibrillarin and snoRNAs to function in enzyme assembly and catalysis. Here we report the 2.9 Å resolution co-crystal structure of an archaeal homolog of Nop56p/Nop58p, Nop5p, in complex with fibrillarin from
Archaeoglobus fulgidus
(AF) and the methyl donor
S
-adenosyl-
L
-methionine. The N-terminal domain of Nop5p forms a complementary surface to fibrillarin that serves to anchor the catalytic subunit and to stabilize cofactor binding. A coiled coil in Nop5p mediates dimerization of two fibrillarin–Nop5p heterodimers for optimal interactions with bipartite box C/D RNAs. Structural analysis and complementary biochemical data demonstrate that the conserved C-terminal domain of Nop5p harbors RNA-binding sites. A model of box C/D snoRNP assembly is proposed based on the presented structural and biochemical data. |
| doi_str_mv | 10.1038/nsb905 |
| format | Article |
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Archaeoglobus fulgidus
(AF) and the methyl donor
S
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L
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Archaeoglobus fulgidus
(AF) and the methyl donor
S
-adenosyl-
L
-methionine. The N-terminal domain of Nop5p forms a complementary surface to fibrillarin that serves to anchor the catalytic subunit and to stabilize cofactor binding. A coiled coil in Nop5p mediates dimerization of two fibrillarin–Nop5p heterodimers for optimal interactions with bipartite box C/D RNAs. Structural analysis and complementary biochemical data demonstrate that the conserved C-terminal domain of Nop5p harbors RNA-binding sites. A model of box C/D snoRNP assembly is proposed based on the presented structural and biochemical data.</description><subject>Amino Acid Sequence</subject><subject>Archaeal Proteins - chemistry</subject><subject>Archaeal Proteins - genetics</subject><subject>Archaeal Proteins - metabolism</subject><subject>Archaeoglobus fulgidus - genetics</subject><subject>Archaeoglobus fulgidus - metabolism</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Binding Sites</subject><subject>Biochemistry</subject><subject>BIOLOGICAL FUNCTIONS</subject><subject>Biological Microscopy</subject><subject>Biomedical and Life Sciences</subject><subject>Catalysis</subject><subject>Chromosomal Proteins, Non-Histone - chemistry</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>Crystallography, X-Ray</subject><subject>Dimerization</subject><subject>Electrophoretic Mobility Shift Assay</subject><subject>Life Sciences</subject><subject>Macromolecular Substances</subject><subject>Membrane Biology</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>Molecular Structure</subject><subject>NATIONAL SYNCHROTRON LIGHT SOURCE</subject><subject>Nuclear Proteins</subject><subject>PROTEIN STRUCTURE</subject><subject>Protein Structure, Tertiary</subject><subject>PROTEINS</subject><subject>Ribonucleoproteins, Small Nucleolar - chemistry</subject><subject>Ribonucleoproteins, Small Nucleolar - genetics</subject><subject>Ribonucleoproteins, Small Nucleolar - metabolism</subject><subject>RNA Editing</subject><subject>RNA, Archaeal - chemistry</subject><subject>RNA, Archaeal - genetics</subject><subject>RNA, Archaeal - metabolism</subject><subject>RNA, Guide - chemistry</subject><subject>RNA, Guide - genetics</subject><subject>RNA, Guide - metabolism</subject><subject>RNA, Small Nucleolar - chemistry</subject><subject>RNA, Small Nucleolar - genetics</subject><subject>RNA, Small Nucleolar - metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Static Electricity</subject><subject>Structural analysis</subject><issn>1545-9993</issn><issn>1072-8368</issn><issn>1545-9985</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV1LwzAUhoMoTqf-BCkKelWXtE2TXHgh8xOGih_XIT1LXUeXzCQF_fdGOhzsxqscch6enJMXoSOCLwjO-cj4SmC6hfYILWgqBKfbf7XIB2jf-znGGaUs30UDklHBucj20OVrcB2EzulEmWlSdwZCY01i60Q5mCmt2qSyX8l4dJ34l8fnBGxEl84G3Rh_gHZq1Xp9uDqH6P325m18n06e7h7GV5MUCipCqjjjjGAuWF6BLmrgmukpphWGKXChCIc6L6mqCItFvMWUM1FWqixJ7EM-RKe91_rQSA9N0DADa4yGIAnFOOqLSJ31VBzvs9M-yEXjQbetMtp2XrKcFJiw7F-QcI5zEv9tiE42wLntnImryizjmSg4Kdc2cNZ7p2u5dM1CuW9JsPwNR_bhRPB4ZeuqhZ6usVUaETjvAR9b5kO79XMbqh9wU5Rw</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Aittaleb, Mohamed</creator><creator>Rashid, Rumana</creator><creator>Chen, Qiong</creator><creator>Palmer, John R.</creator><creator>Daniels, Charles J.</creator><creator>Li, Hong</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20030401</creationdate><title>Structure and function of archaeal box C/D sRNP core proteins</title><author>Aittaleb, Mohamed ; Rashid, Rumana ; Chen, Qiong ; Palmer, John R. ; Daniels, Charles J. ; Li, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-a8787108973bce4fc8e7ed05b0cdc89a18cf365ab17cf3b0c058796ba661c89c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acid Sequence</topic><topic>Archaeal Proteins - 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chemistry</topic><topic>Ribonucleoproteins, Small Nucleolar - genetics</topic><topic>Ribonucleoproteins, Small Nucleolar - metabolism</topic><topic>RNA Editing</topic><topic>RNA, Archaeal - chemistry</topic><topic>RNA, Archaeal - genetics</topic><topic>RNA, Archaeal - metabolism</topic><topic>RNA, Guide - chemistry</topic><topic>RNA, Guide - genetics</topic><topic>RNA, Guide - metabolism</topic><topic>RNA, Small Nucleolar - chemistry</topic><topic>RNA, Small Nucleolar - genetics</topic><topic>RNA, Small Nucleolar - metabolism</topic><topic>Sequence Homology, Amino Acid</topic><topic>Static Electricity</topic><topic>Structural analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aittaleb, Mohamed</creatorcontrib><creatorcontrib>Rashid, Rumana</creatorcontrib><creatorcontrib>Chen, Qiong</creatorcontrib><creatorcontrib>Palmer, John R.</creatorcontrib><creatorcontrib>Daniels, Charles J.</creatorcontrib><creatorcontrib>Li, Hong</creatorcontrib><creatorcontrib>Brookhaven National Laboratory, National Synchrotron Light Source (US)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Nature Structural Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aittaleb, Mohamed</au><au>Rashid, Rumana</au><au>Chen, Qiong</au><au>Palmer, John R.</au><au>Daniels, Charles J.</au><au>Li, Hong</au><aucorp>Brookhaven National Laboratory, National Synchrotron Light Source (US)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure and function of archaeal box C/D sRNP core proteins</atitle><jtitle>Nature Structural Biology</jtitle><stitle>Nat Struct Mol Biol</stitle><addtitle>Nat Struct Biol</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>10</volume><issue>4</issue><spage>256</spage><epage>263</epage><pages>256-263</pages><issn>1545-9993</issn><issn>1072-8368</issn><eissn>1545-9985</eissn><abstract>Nop56p and Nop58p are two core proteins of the box C/D snoRNPs that interact concurrently with fibrillarin and snoRNAs to function in enzyme assembly and catalysis. Here we report the 2.9 Å resolution co-crystal structure of an archaeal homolog of Nop56p/Nop58p, Nop5p, in complex with fibrillarin from
Archaeoglobus fulgidus
(AF) and the methyl donor
S
-adenosyl-
L
-methionine. The N-terminal domain of Nop5p forms a complementary surface to fibrillarin that serves to anchor the catalytic subunit and to stabilize cofactor binding. A coiled coil in Nop5p mediates dimerization of two fibrillarin–Nop5p heterodimers for optimal interactions with bipartite box C/D RNAs. Structural analysis and complementary biochemical data demonstrate that the conserved C-terminal domain of Nop5p harbors RNA-binding sites. A model of box C/D snoRNP assembly is proposed based on the presented structural and biochemical data.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>12598892</pmid><doi>10.1038/nsb905</doi><tpages>8</tpages></addata></record> |
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| ispartof | Nature Structural Biology, 2003-04, Vol.10 (4), p.256-263 |
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| subjects | Amino Acid Sequence Archaeal Proteins - chemistry Archaeal Proteins - genetics Archaeal Proteins - metabolism Archaeoglobus fulgidus - genetics Archaeoglobus fulgidus - metabolism BASIC BIOLOGICAL SCIENCES Binding Sites Biochemistry BIOLOGICAL FUNCTIONS Biological Microscopy Biomedical and Life Sciences Catalysis Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism Crystallography, X-Ray Dimerization Electrophoretic Mobility Shift Assay Life Sciences Macromolecular Substances Membrane Biology Models, Molecular Molecular Sequence Data Molecular Structure NATIONAL SYNCHROTRON LIGHT SOURCE Nuclear Proteins PROTEIN STRUCTURE Protein Structure, Tertiary PROTEINS Ribonucleoproteins, Small Nucleolar - chemistry Ribonucleoproteins, Small Nucleolar - genetics Ribonucleoproteins, Small Nucleolar - metabolism RNA Editing RNA, Archaeal - chemistry RNA, Archaeal - genetics RNA, Archaeal - metabolism RNA, Guide - chemistry RNA, Guide - genetics RNA, Guide - metabolism RNA, Small Nucleolar - chemistry RNA, Small Nucleolar - genetics RNA, Small Nucleolar - metabolism Sequence Homology, Amino Acid Static Electricity Structural analysis |
| title | Structure and function of archaeal box C/D sRNP core proteins |
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