Aprotinin reduces vasoactive medication use during adult liver transplantation
To determine whether aprotinin use during adult liver transplantation results in an improvement in hemodynamic stability. Review of data collected during a prospective, randomized, double-blind trial. Liver transplantation program in a tertiary referral institution. 63 adult patients undergoing orth...
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| Veröffentlicht in: | Journal of clinical anesthesia 2003-02, Vol.15 (1), p.19-23 |
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| creator | Findlay, James Y Kufner, Ronald P |
| description | To determine whether aprotinin use during adult liver transplantation results in an improvement in hemodynamic stability.
Review of data collected during a prospective, randomized, double-blind trial.
Liver transplantation program in a tertiary referral institution.
63 adult patients undergoing orthotopic liver transplantation (OLT).
Patients were randomized to receive either aprotinin (1,000,000 KIU loading dose, followed by an infusion of 250,000 KIU/hr) for the duration of the surgery or a placebo infusion (normal saline).
Hemodynamic parameters (mean systemic blood pressure, cardiac output, systemic vascular resistance, mean pulmonary artery (PA) pressure, and PA occlusion pressure) were compared at set time points during the procedure. The use of vasoactive medications during and after the reperfusion period was compared.
There were no significant differences in any of the measured hemodynamic parameters at any time point. Vasoactive infusions were used in 1 of 33 patients in the aprotinin group and in 6 of 30 patients in the control group (
p < 0.05). Bolus doses of pressor medications during the recirculation period did not differ between groups.
Aprotinin infusion during adult liver transplantation results in less requirement for vasoactive intervention. |
| doi_str_mv | 10.1016/S0952-8180(02)00475-0 |
| format | Article |
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Review of data collected during a prospective, randomized, double-blind trial.
Liver transplantation program in a tertiary referral institution.
63 adult patients undergoing orthotopic liver transplantation (OLT).
Patients were randomized to receive either aprotinin (1,000,000 KIU loading dose, followed by an infusion of 250,000 KIU/hr) for the duration of the surgery or a placebo infusion (normal saline).
Hemodynamic parameters (mean systemic blood pressure, cardiac output, systemic vascular resistance, mean pulmonary artery (PA) pressure, and PA occlusion pressure) were compared at set time points during the procedure. The use of vasoactive medications during and after the reperfusion period was compared.
There were no significant differences in any of the measured hemodynamic parameters at any time point. Vasoactive infusions were used in 1 of 33 patients in the aprotinin group and in 6 of 30 patients in the control group (
p < 0.05). Bolus doses of pressor medications during the recirculation period did not differ between groups.
Aprotinin infusion during adult liver transplantation results in less requirement for vasoactive intervention.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/S0952-8180(02)00475-0</identifier><identifier>PMID: 12657406</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject><![CDATA[Abdominal surgery. Urology. Gynecology. Obstetrics ; Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Aprotinin ; Aprotinin - therapeutic use ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Blood products ; Blood. Blood coagulation. Reticuloendothelial system ; Calcium Chloride - administration & dosage ; Calcium Chloride - pharmacology ; Cardiac Output - drug effects ; Cardiac Output - physiology ; Dopamine ; Double-Blind Method ; Epinephrine - administration & dosage ; Epinephrine - pharmacology ; Female ; hemodynamics ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Hemostatics - therapeutic use ; Humans ; Intraoperative Period ; liver transplantation ; Liver Transplantation - physiology ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Phenylephrine - administration & dosage ; Phenylephrine - pharmacology ; Prospective Studies ; Pulmonary arteries ; Pulmonary Circulation - drug effects ; Pulmonary Circulation - physiology ; Reperfusion Injury - prevention & control ; Studies ; Surgery ; Transplants & implants ; Vascular Resistance - drug effects ; Vascular Resistance - physiology ; Vasoconstrictor Agents - administration & dosage ; Vasoconstrictor Agents - therapeutic use]]></subject><ispartof>Journal of clinical anesthesia, 2003-02, Vol.15 (1), p.19-23</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-8d19d1282b12bafab9c5bbdf823048105919fbd2d5bcaeac86c8d4f75dd519c83</citedby><cites>FETCH-LOGICAL-c419t-8d19d1282b12bafab9c5bbdf823048105919fbd2d5bcaeac86c8d4f75dd519c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0952818002004750$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14710502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12657406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Findlay, James Y</creatorcontrib><creatorcontrib>Kufner, Ronald P</creatorcontrib><title>Aprotinin reduces vasoactive medication use during adult liver transplantation</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>To determine whether aprotinin use during adult liver transplantation results in an improvement in hemodynamic stability.
Review of data collected during a prospective, randomized, double-blind trial.
Liver transplantation program in a tertiary referral institution.
63 adult patients undergoing orthotopic liver transplantation (OLT).
Patients were randomized to receive either aprotinin (1,000,000 KIU loading dose, followed by an infusion of 250,000 KIU/hr) for the duration of the surgery or a placebo infusion (normal saline).
Hemodynamic parameters (mean systemic blood pressure, cardiac output, systemic vascular resistance, mean pulmonary artery (PA) pressure, and PA occlusion pressure) were compared at set time points during the procedure. The use of vasoactive medications during and after the reperfusion period was compared.
There were no significant differences in any of the measured hemodynamic parameters at any time point. Vasoactive infusions were used in 1 of 33 patients in the aprotinin group and in 6 of 30 patients in the control group (
p < 0.05). Bolus doses of pressor medications during the recirculation period did not differ between groups.
Aprotinin infusion during adult liver transplantation results in less requirement for vasoactive intervention.</description><subject>Abdominal surgery. Urology. Gynecology. Obstetrics</subject><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Aprotinin</subject><subject>Aprotinin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Blood products</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Calcium Chloride - administration & dosage</subject><subject>Calcium Chloride - pharmacology</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiac Output - physiology</subject><subject>Dopamine</subject><subject>Double-Blind Method</subject><subject>Epinephrine - administration & dosage</subject><subject>Epinephrine - pharmacology</subject><subject>Female</subject><subject>hemodynamics</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Hemostatics - therapeutic use</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>liver transplantation</subject><subject>Liver Transplantation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - administration & dosage</subject><subject>Phenylephrine - pharmacology</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary Circulation - drug effects</subject><subject>Pulmonary Circulation - physiology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Studies</subject><subject>Surgery</subject><subject>Transplants & implants</subject><subject>Vascular Resistance - drug effects</subject><subject>Vascular Resistance - physiology</subject><subject>Vasoconstrictor Agents - administration & dosage</subject><subject>Vasoconstrictor Agents - therapeutic use</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0E9r2zAYx3FRWto020toMZSN9uDteWQplk6jlP6D0h22nYUsyUXBsTNJDvTdT0lMC7v05MvHDz99CTlD-IaAi--_QHJaChRwCfQKgNW8hAMyQ1FXJeNUHpLZGzkhpzEuIStO8ZicIF3wmsFiRp6v12FIvvd9EZwdjYvFRsdBm-Q3rlg5641OfuiLMbrCjsH3L4W2Y5eKLoNQpKD7uO50n3bsEzlqdRfd5-k7J3_ubn_fPJRPP-8fb66fSsNQplJYlBapoA3SRre6kYY3jW0FrYAJBC5Rto2lljdGO23EwgjL2ppby1EaUc3J1_3dvP7v6GJSKx-N6_IQN4xR1RVWkgNkePEfXA5j6PM2hVAxWaMElhXfKxOGGINr1Tr4lQ6vGaltbrXLrbYtFVC1y62218-n62OTW73_NfXN4MsEdDS6a3Mt4-O7Y3V-LNDsfuydy9E23gUVjXe9yf2DM0nZwX8w5R8eXZzy</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Findlay, James Y</creator><creator>Kufner, Ronald P</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Aprotinin reduces vasoactive medication use during adult liver transplantation</title><author>Findlay, James Y ; Kufner, Ronald P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-8d19d1282b12bafab9c5bbdf823048105919fbd2d5bcaeac86c8d4f75dd519c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Abdominal surgery. Urology. Gynecology. Obstetrics</topic><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Aprotinin</topic><topic>Aprotinin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Blood products</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Calcium Chloride - administration & dosage</topic><topic>Calcium Chloride - pharmacology</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiac Output - physiology</topic><topic>Dopamine</topic><topic>Double-Blind Method</topic><topic>Epinephrine - administration & dosage</topic><topic>Epinephrine - pharmacology</topic><topic>Female</topic><topic>hemodynamics</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Hemostatics - therapeutic use</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>liver transplantation</topic><topic>Liver Transplantation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - administration & dosage</topic><topic>Phenylephrine - pharmacology</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary Circulation - drug effects</topic><topic>Pulmonary Circulation - physiology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Studies</topic><topic>Surgery</topic><topic>Transplants & implants</topic><topic>Vascular Resistance - drug effects</topic><topic>Vascular Resistance - physiology</topic><topic>Vasoconstrictor Agents - administration & dosage</topic><topic>Vasoconstrictor Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Findlay, James Y</creatorcontrib><creatorcontrib>Kufner, Ronald P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Findlay, James Y</au><au>Kufner, Ronald P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aprotinin reduces vasoactive medication use during adult liver transplantation</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>15</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>To determine whether aprotinin use during adult liver transplantation results in an improvement in hemodynamic stability.
Review of data collected during a prospective, randomized, double-blind trial.
Liver transplantation program in a tertiary referral institution.
63 adult patients undergoing orthotopic liver transplantation (OLT).
Patients were randomized to receive either aprotinin (1,000,000 KIU loading dose, followed by an infusion of 250,000 KIU/hr) for the duration of the surgery or a placebo infusion (normal saline).
Hemodynamic parameters (mean systemic blood pressure, cardiac output, systemic vascular resistance, mean pulmonary artery (PA) pressure, and PA occlusion pressure) were compared at set time points during the procedure. The use of vasoactive medications during and after the reperfusion period was compared.
There were no significant differences in any of the measured hemodynamic parameters at any time point. Vasoactive infusions were used in 1 of 33 patients in the aprotinin group and in 6 of 30 patients in the control group (
p < 0.05). Bolus doses of pressor medications during the recirculation period did not differ between groups.
Aprotinin infusion during adult liver transplantation results in less requirement for vasoactive intervention.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12657406</pmid><doi>10.1016/S0952-8180(02)00475-0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of clinical anesthesia, 2003-02, Vol.15 (1), p.19-23 |
| issn | 0952-8180 1873-4529 |
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| subjects | Abdominal surgery. Urology. Gynecology. Obstetrics Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Aprotinin Aprotinin - therapeutic use Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Blood products Blood. Blood coagulation. Reticuloendothelial system Calcium Chloride - administration & dosage Calcium Chloride - pharmacology Cardiac Output - drug effects Cardiac Output - physiology Dopamine Double-Blind Method Epinephrine - administration & dosage Epinephrine - pharmacology Female hemodynamics Hemodynamics - drug effects Hemodynamics - physiology Hemostatics - therapeutic use Humans Intraoperative Period liver transplantation Liver Transplantation - physiology Male Medical sciences Middle Aged Pharmacology. Drug treatments Phenylephrine - administration & dosage Phenylephrine - pharmacology Prospective Studies Pulmonary arteries Pulmonary Circulation - drug effects Pulmonary Circulation - physiology Reperfusion Injury - prevention & control Studies Surgery Transplants & implants Vascular Resistance - drug effects Vascular Resistance - physiology Vasoconstrictor Agents - administration & dosage Vasoconstrictor Agents - therapeutic use |
| title | Aprotinin reduces vasoactive medication use during adult liver transplantation |
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