Early rearing conditions alter immune responses in the developing infant primate
The influence of early rearing conditions on immunologic development was investigated in infant monkeys. Lymphocyte proliferation, natural killer cell activity, and antibody responses to tetanus vaccination were compared in 30 rhesus monkeys reared under five different conditions. Lymphocyte respons...
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| Veröffentlicht in: | Pediatrics (Evanston) 1992-09, Vol.90 (3), p.505-509 |
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| container_title | Pediatrics (Evanston) |
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| creator | COE, C. L LUBACH, G. R SCHNEIDER, M. L DIERSCHKE, D. J ERSHLER, W. B |
| description | The influence of early rearing conditions on immunologic development was investigated in infant monkeys. Lymphocyte proliferation, natural killer cell activity, and antibody responses to tetanus vaccination were compared in 30 rhesus monkeys reared under five different conditions. Lymphocyte responses to two mitogens (concanavalin A and pokeweed) were significantly increased in infants from disturbed rearing conditions compared with control infants that had been reared in an undisturbed manner by their mothers. The largest increases occurred in nursery-reared monkeys that had been fed Similac infant formula. The nursery-reared monkeys also tended to show lower natural killer cell activity, but there were no significant differences in response to vaccination. These findings support other research indicating that psychologic and nutritional aspects of the early rearing environment may have long-lasting effects on some, but not all, immune responses in the developing infant. |
| doi_str_mv | 10.1542/peds.90.3.505 |
| format | Article |
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These findings support other research indicating that psychologic and nutritional aspects of the early rearing environment may have long-lasting effects on some, but not all, immune responses in the developing infant.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.90.3.505</identifier><identifier>PMID: 1513616</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Animal Husbandry - standards ; Animals ; Animals, Newborn - blood ; Animals, Newborn - immunology ; Animals, Newborn - psychology ; Antibody Formation - immunology ; Behavioral psychophysiology ; Biological and medical sciences ; Breast feeding ; Development ; Evaluation Studies as Topic ; Fundamental and applied biological sciences. 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L</creatorcontrib><creatorcontrib>DIERSCHKE, D. J</creatorcontrib><creatorcontrib>ERSHLER, W. B</creatorcontrib><title>Early rearing conditions alter immune responses in the developing infant primate</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The influence of early rearing conditions on immunologic development was investigated in infant monkeys. Lymphocyte proliferation, natural killer cell activity, and antibody responses to tetanus vaccination were compared in 30 rhesus monkeys reared under five different conditions. Lymphocyte responses to two mitogens (concanavalin A and pokeweed) were significantly increased in infants from disturbed rearing conditions compared with control infants that had been reared in an undisturbed manner by their mothers. The largest increases occurred in nursery-reared monkeys that had been fed Similac infant formula. The nursery-reared monkeys also tended to show lower natural killer cell activity, but there were no significant differences in response to vaccination. These findings support other research indicating that psychologic and nutritional aspects of the early rearing environment may have long-lasting effects on some, but not all, immune responses in the developing infant.</description><subject>Animal Husbandry - standards</subject><subject>Animals</subject><subject>Animals, Newborn - blood</subject><subject>Animals, Newborn - immunology</subject><subject>Animals, Newborn - psychology</subject><subject>Antibody Formation - immunology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Breast feeding</subject><subject>Development</subject><subject>Evaluation Studies as Topic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunity</subject><subject>Immunity (Physiology)</subject><subject>Immunocompetence</subject><subject>Infant development</subject><subject>Infants</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Activation - immunology</subject><subject>Macaca mulatta</subject><subject>Methods</subject><subject>Miscellaneous</subject><subject>Mothers - psychology</subject><subject>Object Attachment</subject><subject>Parenting</subject><subject>Physiological aspects</subject><subject>Psychological aspects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early rearing conditions alter immune responses in the developing infant primate</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1992-09-01</date><risdate>1992</risdate><volume>90</volume><issue>3</issue><spage>505</spage><epage>509</epage><pages>505-509</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>The influence of early rearing conditions on immunologic development was investigated in infant monkeys. Lymphocyte proliferation, natural killer cell activity, and antibody responses to tetanus vaccination were compared in 30 rhesus monkeys reared under five different conditions. Lymphocyte responses to two mitogens (concanavalin A and pokeweed) were significantly increased in infants from disturbed rearing conditions compared with control infants that had been reared in an undisturbed manner by their mothers. The largest increases occurred in nursery-reared monkeys that had been fed Similac infant formula. The nursery-reared monkeys also tended to show lower natural killer cell activity, but there were no significant differences in response to vaccination. These findings support other research indicating that psychologic and nutritional aspects of the early rearing environment may have long-lasting effects on some, but not all, immune responses in the developing infant.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>1513616</pmid><doi>10.1542/peds.90.3.505</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animal Husbandry - standards Animals Animals, Newborn - blood Animals, Newborn - immunology Animals, Newborn - psychology Antibody Formation - immunology Behavioral psychophysiology Biological and medical sciences Breast feeding Development Evaluation Studies as Topic Fundamental and applied biological sciences. Psychology Immunity Immunity (Physiology) Immunocompetence Infant development Infants Killer Cells, Natural - immunology Lymphocyte Activation - immunology Macaca mulatta Methods Miscellaneous Mothers - psychology Object Attachment Parenting Physiological aspects Psychological aspects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Tetanus Toxoid - immunology |
| title | Early rearing conditions alter immune responses in the developing infant primate |
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