Alterations in human fetal hematopoiesis are associated with maternal HIV infection

In the majority of adult and pediatric patients with AIDS, hematologic abnormalities including leukopenia, anemia, and thrombocytopenia are commonly observed. In addition to these findings, changes in hematopoietic progenitor cells occur, including a reduction of multipotential-forming units, granul...

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Veröffentlicht in:Pediatric research 1992-08, Vol.32 (2), p.155-159
Hauptverfasser: Burstein, Y, Rashbaum, W K, Hatch, W C, Calvelli, T, Golodner, M, Soeiro, R, Lyman, W D
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container_end_page 159
container_issue 2
container_start_page 155
container_title Pediatric research
container_volume 32
creator Burstein, Y
Rashbaum, W K
Hatch, W C
Calvelli, T
Golodner, M
Soeiro, R
Lyman, W D
description In the majority of adult and pediatric patients with AIDS, hematologic abnormalities including leukopenia, anemia, and thrombocytopenia are commonly observed. In addition to these findings, changes in hematopoietic progenitor cells occur, including a reduction of multipotential-forming units, granulocyte-macrophages, macrophage as well as eosinophil colony-forming units, and bone marrow erythroid burst-forming units. This study examined alterations in human fetal liver hematopoiesis in 2nd trimester abortuses from human immunodeficiency virus (HIV)-seropositive women. The differentiation and growth potential of hematopoietic cells in vitro were monitored. Upon initial isolation, some populations of liver hematopoietic cells from abortuses of HIV-seropositive women were significantly decreased when compared to age-matched samples from fetuses of normal females including the percentage of early T cells [cluster of differentiation (CD)2], B cells (CD19), and early monocytes (CD14). A decrease in multipotent progenitors (CD34), myelomonocytes (CD33), and panleukocytes (CD45) was also observed. In contrast, after 21 d in culture, cells from HIV abortuses demonstrated an increase in the percentage of CD14 cells when stimulated with erythropoietin and granulocyte-monocyte colony-stimulating factor, as well as an increase in CD45 phenotype after exposure to granulocyte-monocyte colony-stimulating factor alone. These samples showed a persistence of erythropoietic elements (transferrin and CD36 phenotype) when compared to normal controls. No significant difference in the in vitro growth of hematopoietic progenitors (bone marrow erythroid burst-forming units, granulocyte-macrophage colony-forming units, and multipotential forming units) between these samples and normal controls was found.
doi_str_mv 10.1203/00006450-199208000-00006
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source MEDLINE; Journals@Ovid Ovid Autoload; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects AIDS/HIV
Female
Fetus - pathology
Hematopoiesis
Hematopoietic Stem Cells - pathology
HIV Infections - complications
Humans
Liver - pathology
Maternal-Fetal Exchange
Pregnancy
Pregnancy Complications, Infectious - pathology
title Alterations in human fetal hematopoiesis are associated with maternal HIV infection
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