Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors
Recent studies indicate that nitric oxide (NO) synthase inhibitors have antidepressant-like potential in various animal models. In the present study the behavioural activity of the NO synthase inhibitors, N G-nitro- l-arginine ( l-NA) and 7-nitroindazole (7-NI), were assessed in a modified rat force...
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| Veröffentlicht in: | Neuropharmacology 2003-04, Vol.44 (5), p.616-623 |
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| creator | Harkin, A Connor, T.J Walsh, M St John, N Kelly, J.P |
| description | Recent studies indicate that nitric oxide (NO) synthase inhibitors have antidepressant-like potential in various animal models. In the present study the behavioural activity of the NO synthase inhibitors,
N
G-nitro-
l-arginine (
l-NA) and 7-nitroindazole (7-NI), were assessed in a modified rat forced swimming test (FST). Both
l-NA and 7-NI, dose dependently reduced immobility and increased swimming behaviour in the rat FST. This behavioural profile parallels the one previously shown with selective serotonin re-uptake inhibitors and serotonergic agonists. Thus, we examined the role of serotonin mediating the behavioural effects of
l-NA and 7-NI in the rat FST. Depletion of endogenous serotonin using
para-chlorophenylalanine (
pCPA; 3×150 mg/kg, i.p.) completely blocked
l-NA (20 mg/kg, i.p.) and 7-NI (20 mg/kg, i.p.)-induced reductions in immobility and increases in swimming behaviour during the FST. In conclusion these observations suggest that NO synthase inhibitors elicit their antidepressant-like activity in the modified swimming test through a serotonin dependent mechanism. |
| doi_str_mv | 10.1016/S0028-3908(03)00030-3 |
| format | Article |
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N
G-nitro-
l-arginine (
l-NA) and 7-nitroindazole (7-NI), were assessed in a modified rat forced swimming test (FST). Both
l-NA and 7-NI, dose dependently reduced immobility and increased swimming behaviour in the rat FST. This behavioural profile parallels the one previously shown with selective serotonin re-uptake inhibitors and serotonergic agonists. Thus, we examined the role of serotonin mediating the behavioural effects of
l-NA and 7-NI in the rat FST. Depletion of endogenous serotonin using
para-chlorophenylalanine (
pCPA; 3×150 mg/kg, i.p.) completely blocked
l-NA (20 mg/kg, i.p.) and 7-NI (20 mg/kg, i.p.)-induced reductions in immobility and increases in swimming behaviour during the FST. In conclusion these observations suggest that NO synthase inhibitors elicit their antidepressant-like activity in the modified swimming test through a serotonin dependent mechanism.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/S0028-3908(03)00030-3</identifier><identifier>PMID: 12668047</identifier><identifier>CODEN: NEPHBW</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antidepressant ; Antidepressive Agents - pharmacology ; Antidepressive Agents - therapeutic use ; Behaviour ; Biological and medical sciences ; Depression ; Depression - drug therapy ; Depression - metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors - pharmacology ; Enzyme Inhibitors - therapeutic use ; Forced swimming test ; Immobilization - physiology ; Indazoles - pharmacology ; Indazoles - therapeutic use ; Male ; Medical sciences ; Motor Activity - drug effects ; Motor Activity - physiology ; Nitric oxide synthase ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - metabolism ; Nitroarginine - pharmacology ; Nitroarginine - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Serotonin ; Serotonin - metabolism</subject><ispartof>Neuropharmacology, 2003-04, Vol.44 (5), p.616-623</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-9aff5b4c1f7c42097419fb88404b18a27741ce7c71215c9ac9d0784654fb246d3</citedby><cites>FETCH-LOGICAL-c422t-9aff5b4c1f7c42097419fb88404b18a27741ce7c71215c9ac9d0784654fb246d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0028-3908(03)00030-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14642067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12668047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harkin, A</creatorcontrib><creatorcontrib>Connor, T.J</creatorcontrib><creatorcontrib>Walsh, M</creatorcontrib><creatorcontrib>St John, N</creatorcontrib><creatorcontrib>Kelly, J.P</creatorcontrib><title>Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Recent studies indicate that nitric oxide (NO) synthase inhibitors have antidepressant-like potential in various animal models. In the present study the behavioural activity of the NO synthase inhibitors,
N
G-nitro-
l-arginine (
l-NA) and 7-nitroindazole (7-NI), were assessed in a modified rat forced swimming test (FST). Both
l-NA and 7-NI, dose dependently reduced immobility and increased swimming behaviour in the rat FST. This behavioural profile parallels the one previously shown with selective serotonin re-uptake inhibitors and serotonergic agonists. Thus, we examined the role of serotonin mediating the behavioural effects of
l-NA and 7-NI in the rat FST. Depletion of endogenous serotonin using
para-chlorophenylalanine (
pCPA; 3×150 mg/kg, i.p.) completely blocked
l-NA (20 mg/kg, i.p.) and 7-NI (20 mg/kg, i.p.)-induced reductions in immobility and increases in swimming behaviour during the FST. In conclusion these observations suggest that NO synthase inhibitors elicit their antidepressant-like activity in the modified swimming test through a serotonin dependent mechanism.</description><subject>Animals</subject><subject>Antidepressant</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Behaviour</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Depression - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Forced swimming test</subject><subject>Immobilization - physiology</subject><subject>Indazoles - pharmacology</subject><subject>Indazoles - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Nitric oxide synthase</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitroarginine - pharmacology</subject><subject>Nitroarginine - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUha0K1A6FRyjKBgSL0OufxM6qqir-pEosWpbIcpzrjiFjD7YH0bfH6YzositbV9-xr75DyBmFDxRof34DwFTLB1DvgL8HAA4tPyIrqiRvJfTiGVn9R07Ii5x_Vkgoqo7JCWV9r0DIFflxgymWGDDdedtscPKm-Bia6JqyxsaE4ifcJsy5XtvZ_8IGnUNb8oIEX1KNxb8VavJ9KGuTsfFh7UdfYsovyXNn5oyvDucp-f7p4-3Vl_b62-evV5fXrRWMlXYwznWjsNTJOoBBCjq4USkBYqTKMFkHFqWVlNHODsYOE0gl-k64kYl-4qfk7f7dbYq_d5iL3vhscZ5NwLjLWnLKheTdk2C1x5hUvILdHrQp5pzQ6W3yG5PuNQW9FKAfCtCLXQ1cPxSgl9zrwwe7sdp8TB2MV-DNATDZmtklE6zPj5zoq4F-4S72HFZvfzwmna3HYGtDqerXU_RPrPIPmR2ifg</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Harkin, A</creator><creator>Connor, T.J</creator><creator>Walsh, M</creator><creator>St John, N</creator><creator>Kelly, J.P</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors</title><author>Harkin, A ; Connor, T.J ; Walsh, M ; St John, N ; Kelly, J.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-9aff5b4c1f7c42097419fb88404b18a27741ce7c71215c9ac9d0784654fb246d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antidepressant</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Behaviour</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depression - drug therapy</topic><topic>Depression - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Forced swimming test</topic><topic>Immobilization - physiology</topic><topic>Indazoles - pharmacology</topic><topic>Indazoles - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Nitric oxide synthase</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitroarginine - pharmacology</topic><topic>Nitroarginine - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harkin, A</creatorcontrib><creatorcontrib>Connor, T.J</creatorcontrib><creatorcontrib>Walsh, M</creatorcontrib><creatorcontrib>St John, N</creatorcontrib><creatorcontrib>Kelly, J.P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harkin, A</au><au>Connor, T.J</au><au>Walsh, M</au><au>St John, N</au><au>Kelly, J.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>44</volume><issue>5</issue><spage>616</spage><epage>623</epage><pages>616-623</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><coden>NEPHBW</coden><abstract>Recent studies indicate that nitric oxide (NO) synthase inhibitors have antidepressant-like potential in various animal models. In the present study the behavioural activity of the NO synthase inhibitors,
N
G-nitro-
l-arginine (
l-NA) and 7-nitroindazole (7-NI), were assessed in a modified rat forced swimming test (FST). Both
l-NA and 7-NI, dose dependently reduced immobility and increased swimming behaviour in the rat FST. This behavioural profile parallels the one previously shown with selective serotonin re-uptake inhibitors and serotonergic agonists. Thus, we examined the role of serotonin mediating the behavioural effects of
l-NA and 7-NI in the rat FST. Depletion of endogenous serotonin using
para-chlorophenylalanine (
pCPA; 3×150 mg/kg, i.p.) completely blocked
l-NA (20 mg/kg, i.p.) and 7-NI (20 mg/kg, i.p.)-induced reductions in immobility and increases in swimming behaviour during the FST. In conclusion these observations suggest that NO synthase inhibitors elicit their antidepressant-like activity in the modified swimming test through a serotonin dependent mechanism.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12668047</pmid><doi>10.1016/S0028-3908(03)00030-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antidepressant Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Behaviour Biological and medical sciences Depression Depression - drug therapy Depression - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Forced swimming test Immobilization - physiology Indazoles - pharmacology Indazoles - therapeutic use Male Medical sciences Motor Activity - drug effects Motor Activity - physiology Nitric oxide synthase Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitroarginine - pharmacology Nitroarginine - therapeutic use Rats Rats, Sprague-Dawley Serotonin Serotonin - metabolism |
| title | Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors |
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