Recurrent Lymphangiomyomatosis after Transplantation: Genetic Analyses Reveal a Metastatic Mechanism

Lymphangiomyomatosis (LAM) is characterized by the proliferation of abnormal smooth muscle cells and cystic degeneration of the lung. LAM affects almost exclusively young women. Although lung transplantation provides effective therapy for end-stage LAM, there are reports of LAM recurrence after lung...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2003-04, Vol.167 (7), p.976-982
Hauptverfasser:	Karbowniczek, Magdalena, Astrinidis, Aristotelis, Balsara, Binaifer R, Testa, Joseph R, Lium, James H, Colby, Thomas V, McCormack, Francis X, Henske, Elizabeth Petri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Base Sequence Biological and medical sciences Biomarkers, Tumor - genetics Biopsy Chromosomes, Human, Pair 16 - genetics Chromosomes, Human, Y - genetics DNA, Neoplasm - genetics Exons - genetics Female Genes, Tumor Suppressor Heterozygote Humans Loss of Heterozygosity - genetics Lung Lung Neoplasms - genetics Lung Neoplasms - secondary Lung Neoplasms - surgery Lung Transplantation Lymph Nodes Lymphangioleiomyomatosis - genetics Lymphangioleiomyomatosis - pathology Lymphangioleiomyomatosis - surgery Medical sciences Microsatellite Repeats - genetics Neoplasm Recurrence, Local - etiology Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - secondary Pneumology Postoperative Complications - etiology Repressor Proteins - genetics Respiratory system : syndromes and miscellaneous diseases Treatment Failure Tumor Suppressor Proteins
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