Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle
This study was conducted to identify polymorphisms in the promoter and coding regions of the bovine growth hormone and growth hormone receptor genes and to study association of polymorphisms identified in these genes with growth traits and serum insulin-like growth factor-I (IGF-I) concentration. Th...
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Veröffentlicht in: | Journal of animal science 2003-03, Vol.81 (3), p.641-648 |
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creator | Ge, W Davis, M.E Hines, H.C Irvin, K.M Simmen, R.C.M |
description | This study was conducted to identify polymorphisms in the promoter and coding regions of the bovine growth hormone and growth hormone receptor genes and to study association of polymorphisms identified in these genes with growth traits and serum insulin-like growth factor-I (IGF-I) concentration. The denaturing gradient gel electrophoresis method and sequencing were utilized to identify three new single nucleotide polymorphisms in the promoter region of the growth hormone gene in Angus cattle. Polymerase chain reaction-based restriction fragment length polymorphism procedures were developed for rapid determination of the single nucleotide polymorphism genotypes in the growth hormone and the growth hormone receptor genes among Angus calves from lines divergently selected for high or low blood serum IGF-I concentration. The IGF-I concentration and growth traits were analyzed using animal models. The single nucleotide polymorphism in the promoter region of the growth hormone receptor gene was associated with serum IGF-I concentration on d 42 of the postweaning test and with mean IGF-I concentration. The associated effects of the markers need to be verified in other populations. |
doi_str_mv | 10.2527/2003.813641x |
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The denaturing gradient gel electrophoresis method and sequencing were utilized to identify three new single nucleotide polymorphisms in the promoter region of the growth hormone gene in Angus cattle. Polymerase chain reaction-based restriction fragment length polymorphism procedures were developed for rapid determination of the single nucleotide polymorphism genotypes in the growth hormone and the growth hormone receptor genes among Angus calves from lines divergently selected for high or low blood serum IGF-I concentration. The IGF-I concentration and growth traits were analyzed using animal models. The single nucleotide polymorphism in the promoter region of the growth hormone receptor gene was associated with serum IGF-I concentration on d 42 of the postweaning test and with mean IGF-I concentration. The associated effects of the markers need to be verified in other populations.</description><identifier>ISSN: 0021-8812</identifier><identifier>EISSN: 1525-3163</identifier><identifier>DOI: 10.2527/2003.813641x</identifier><identifier>PMID: 12661644</identifier><language>eng</language><publisher>Savoy, IL: Am Soc Animal Sci</publisher><subject>Angus ; animal models ; Animal productions ; Animals ; Biological and medical sciences ; blood serum ; cattle ; Cattle - blood ; Cattle - genetics ; Cattle - growth & development ; denaturing gradient gel electrophoresis ; Fundamental and applied biological sciences. Psychology ; genes ; Genetic Markers ; Genotype ; Growth Hormone - genetics ; growth traits ; insulin-like growth factor I ; Insulin-Like Growth Factor I - analysis ; Point Mutation - genetics ; polymerase chain reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; promoter regions ; Promoter Regions, Genetic ; Receptors, Somatotropin - genetics ; restriction fragment length polymorphism ; single nucleotide polymorphism ; somatotropin ; Terrestrial animal productions ; Vertebrates</subject><ispartof>Journal of animal science, 2003-03, Vol.81 (3), p.641-648</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14596409$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12661644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ge, W</creatorcontrib><creatorcontrib>Davis, M.E</creatorcontrib><creatorcontrib>Hines, H.C</creatorcontrib><creatorcontrib>Irvin, K.M</creatorcontrib><creatorcontrib>Simmen, R.C.M</creatorcontrib><title>Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle</title><title>Journal of animal science</title><addtitle>J Anim Sci</addtitle><description>This study was conducted to identify polymorphisms in the promoter and coding regions of the bovine growth hormone and growth hormone receptor genes and to study association of polymorphisms identified in these genes with growth traits and serum insulin-like growth factor-I (IGF-I) concentration. The denaturing gradient gel electrophoresis method and sequencing were utilized to identify three new single nucleotide polymorphisms in the promoter region of the growth hormone gene in Angus cattle. Polymerase chain reaction-based restriction fragment length polymorphism procedures were developed for rapid determination of the single nucleotide polymorphism genotypes in the growth hormone and the growth hormone receptor genes among Angus calves from lines divergently selected for high or low blood serum IGF-I concentration. The IGF-I concentration and growth traits were analyzed using animal models. The single nucleotide polymorphism in the promoter region of the growth hormone receptor gene was associated with serum IGF-I concentration on d 42 of the postweaning test and with mean IGF-I concentration. The associated effects of the markers need to be verified in other populations.</description><subject>Angus</subject><subject>animal models</subject><subject>Animal productions</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>cattle</subject><subject>Cattle - blood</subject><subject>Cattle - genetics</subject><subject>Cattle - growth & development</subject><subject>denaturing gradient gel electrophoresis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genes</subject><subject>Genetic Markers</subject><subject>Genotype</subject><subject>Growth Hormone - genetics</subject><subject>growth traits</subject><subject>insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Point Mutation - genetics</subject><subject>polymerase chain reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>promoter regions</subject><subject>Promoter Regions, Genetic</subject><subject>Receptors, Somatotropin - genetics</subject><subject>restriction fragment length polymorphism</subject><subject>single nucleotide polymorphism</subject><subject>somatotropin</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><issn>0021-8812</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0Eokvhxhl8gVuKx05s57iq-KhUiQP0HDmOnbg4drAdLf1__DACu1DEhdNI7zzzaKQZhJ4DuaANFW8oIexCAuM1fHuAdtDQpmLA2UO0I4RCJSXQM_Qk51tCgDZt8xidAeUceF3v0Pd9zlE7VVwMOFqcXRi9wWHV3sTiBoOX6O_mmJbJ5TljF3CZDB5TPJQJTzHNMRiswvBvlIw2S4kJjyaYjA9u6_U-xgFnk9Z5E-XVu1B59-WPzir9c-IK6xi0CSUd1_rLvkWu_NpiH8Y1Y61K8eYpemSVz-bZqZ6jm3dvP19-qK4_vr-63F9XllFaKtESq1kjKFgqW6OoYoNouBVaEiuNakAJaFmvGNdCaCBbatsegPUCNG_YOXp99C4pfl1NLt3ssjbeq2DimjvBgDEi_g-ClJKImmzgixO49rMZuiW5WaW77veBNuDVCVBZK2-TCtrle65uWl6T9p6b3DgdXDJdnpX3mxa6W5UldKzbPmTjXh45q2KnxrS5bj5RAjUhpBU1B_YDFe25zg</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Ge, W</creator><creator>Davis, M.E</creator><creator>Hines, H.C</creator><creator>Irvin, K.M</creator><creator>Simmen, R.C.M</creator><general>Am Soc Animal Sci</general><general>American Society of Animal Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle</title><author>Ge, W ; Davis, M.E ; Hines, H.C ; Irvin, K.M ; Simmen, R.C.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f322t-790fc35721f289ea2a3d756f7c80f8ea51a7193ba36c77c100f8f9b113b71c653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Angus</topic><topic>animal models</topic><topic>Animal productions</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>cattle</topic><topic>Cattle - blood</topic><topic>Cattle - genetics</topic><topic>Cattle - growth & development</topic><topic>denaturing gradient gel electrophoresis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genes</topic><topic>Genetic Markers</topic><topic>Genotype</topic><topic>Growth Hormone - genetics</topic><topic>growth traits</topic><topic>insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Point Mutation - genetics</topic><topic>polymerase chain reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>promoter regions</topic><topic>Promoter Regions, Genetic</topic><topic>Receptors, Somatotropin - genetics</topic><topic>restriction fragment length polymorphism</topic><topic>single nucleotide polymorphism</topic><topic>somatotropin</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ge, W</creatorcontrib><creatorcontrib>Davis, M.E</creatorcontrib><creatorcontrib>Hines, H.C</creatorcontrib><creatorcontrib>Irvin, K.M</creatorcontrib><creatorcontrib>Simmen, R.C.M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ge, W</au><au>Davis, M.E</au><au>Hines, H.C</au><au>Irvin, K.M</au><au>Simmen, R.C.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>81</volume><issue>3</issue><spage>641</spage><epage>648</epage><pages>641-648</pages><issn>0021-8812</issn><eissn>1525-3163</eissn><abstract>This study was conducted to identify polymorphisms in the promoter and coding regions of the bovine growth hormone and growth hormone receptor genes and to study association of polymorphisms identified in these genes with growth traits and serum insulin-like growth factor-I (IGF-I) concentration. The denaturing gradient gel electrophoresis method and sequencing were utilized to identify three new single nucleotide polymorphisms in the promoter region of the growth hormone gene in Angus cattle. Polymerase chain reaction-based restriction fragment length polymorphism procedures were developed for rapid determination of the single nucleotide polymorphism genotypes in the growth hormone and the growth hormone receptor genes among Angus calves from lines divergently selected for high or low blood serum IGF-I concentration. The IGF-I concentration and growth traits were analyzed using animal models. The single nucleotide polymorphism in the promoter region of the growth hormone receptor gene was associated with serum IGF-I concentration on d 42 of the postweaning test and with mean IGF-I concentration. The associated effects of the markers need to be verified in other populations.</abstract><cop>Savoy, IL</cop><pub>Am Soc Animal Sci</pub><pmid>12661644</pmid><doi>10.2527/2003.813641x</doi><tpages>8</tpages></addata></record> |
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subjects | Angus animal models Animal productions Animals Biological and medical sciences blood serum cattle Cattle - blood Cattle - genetics Cattle - growth & development denaturing gradient gel electrophoresis Fundamental and applied biological sciences. Psychology genes Genetic Markers Genotype Growth Hormone - genetics growth traits insulin-like growth factor I Insulin-Like Growth Factor I - analysis Point Mutation - genetics polymerase chain reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide promoter regions Promoter Regions, Genetic Receptors, Somatotropin - genetics restriction fragment length polymorphism single nucleotide polymorphism somatotropin Terrestrial animal productions Vertebrates |
title | Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle |
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