Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle

This study was conducted to identify polymorphisms in the promoter and coding regions of the bovine growth hormone and growth hormone receptor genes and to study association of polymorphisms identified in these genes with growth traits and serum insulin-like growth factor-I (IGF-I) concentration. Th...

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Veröffentlicht in:Journal of animal science 2003-03, Vol.81 (3), p.641-648
Hauptverfasser: Ge, W, Davis, M.E, Hines, H.C, Irvin, K.M, Simmen, R.C.M
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container_end_page 648
container_issue 3
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container_title Journal of animal science
container_volume 81
creator Ge, W
Davis, M.E
Hines, H.C
Irvin, K.M
Simmen, R.C.M
description This study was conducted to identify polymorphisms in the promoter and coding regions of the bovine growth hormone and growth hormone receptor genes and to study association of polymorphisms identified in these genes with growth traits and serum insulin-like growth factor-I (IGF-I) concentration. The denaturing gradient gel electrophoresis method and sequencing were utilized to identify three new single nucleotide polymorphisms in the promoter region of the growth hormone gene in Angus cattle. Polymerase chain reaction-based restriction fragment length polymorphism procedures were developed for rapid determination of the single nucleotide polymorphism genotypes in the growth hormone and the growth hormone receptor genes among Angus calves from lines divergently selected for high or low blood serum IGF-I concentration. The IGF-I concentration and growth traits were analyzed using animal models. The single nucleotide polymorphism in the promoter region of the growth hormone receptor gene was associated with serum IGF-I concentration on d 42 of the postweaning test and with mean IGF-I concentration. The associated effects of the markers need to be verified in other populations.
doi_str_mv 10.2527/2003.813641x
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Psychology</subject><subject>genes</subject><subject>Genetic Markers</subject><subject>Genotype</subject><subject>Growth Hormone - genetics</subject><subject>growth traits</subject><subject>insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Point Mutation - genetics</subject><subject>polymerase chain reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>promoter regions</subject><subject>Promoter Regions, Genetic</subject><subject>Receptors, Somatotropin - genetics</subject><subject>restriction fragment length polymorphism</subject><subject>single nucleotide polymorphism</subject><subject>somatotropin</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><issn>0021-8812</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0Eokvhxhl8gVuKx05s57iq-KhUiQP0HDmOnbg4drAdLf1__DACu1DEhdNI7zzzaKQZhJ4DuaANFW8oIexCAuM1fHuAdtDQpmLA2UO0I4RCJSXQM_Qk51tCgDZt8xidAeUceF3v0Pd9zlE7VVwMOFqcXRi9wWHV3sTiBoOX6O_mmJbJ5TljF3CZDB5TPJQJTzHNMRiswvBvlIw2S4kJjyaYjA9u6_U-xgFnk9Z5E-XVu1B59-WPzir9c-IK6xi0CSUd1_rLvkWu_NpiH8Y1Y61K8eYpemSVz-bZqZ6jm3dvP19-qK4_vr-63F9XllFaKtESq1kjKFgqW6OoYoNouBVaEiuNakAJaFmvGNdCaCBbatsegPUCNG_YOXp99C4pfl1NLt3ssjbeq2DimjvBgDEi_g-ClJKImmzgixO49rMZuiW5WaW77veBNuDVCVBZK2-TCtrle65uWl6T9p6b3DgdXDJdnpX3mxa6W5UldKzbPmTjXh45q2KnxrS5bj5RAjUhpBU1B_YDFe25zg</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Ge, W</creator><creator>Davis, M.E</creator><creator>Hines, H.C</creator><creator>Irvin, K.M</creator><creator>Simmen, R.C.M</creator><general>Am Soc Animal Sci</general><general>American Society of Animal Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle</title><author>Ge, W ; Davis, M.E ; Hines, H.C ; Irvin, K.M ; Simmen, R.C.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f322t-790fc35721f289ea2a3d756f7c80f8ea51a7193ba36c77c100f8f9b113b71c653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Angus</topic><topic>animal models</topic><topic>Animal productions</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>cattle</topic><topic>Cattle - blood</topic><topic>Cattle - genetics</topic><topic>Cattle - growth &amp; development</topic><topic>denaturing gradient gel electrophoresis</topic><topic>Fundamental and applied biological sciences. 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source MEDLINE; Oxford Journals
subjects Angus
animal models
Animal productions
Animals
Biological and medical sciences
blood serum
cattle
Cattle - blood
Cattle - genetics
Cattle - growth & development
denaturing gradient gel electrophoresis
Fundamental and applied biological sciences. Psychology
genes
Genetic Markers
Genotype
Growth Hormone - genetics
growth traits
insulin-like growth factor I
Insulin-Like Growth Factor I - analysis
Point Mutation - genetics
polymerase chain reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
promoter regions
Promoter Regions, Genetic
Receptors, Somatotropin - genetics
restriction fragment length polymorphism
single nucleotide polymorphism
somatotropin
Terrestrial animal productions
Vertebrates
title Association of single nucleotide polymorphisms in the growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in Angus cattle
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