Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules
In mice, the NK1.1 alloantigen is expressed on all NK cells and it initiates transmembrane signals that activate cytotoxicity. NK1.1 has been mapped to a chromosomal region that encodes two families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encod...
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| Veröffentlicht in: | The Journal of immunology (1950) 1992-09, Vol.149 (5), p.1631-1635 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 149 |
| creator | Ryan, JC Turck, J Niemi, EC Yokoyama, WM Seaman, WE |
| description | In mice, the NK1.1 alloantigen is expressed on all NK cells and it initiates transmembrane signals that activate cytotoxicity. NK1.1 has been mapped to a chromosomal region that encodes two families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encode type II integral membrane proteins whose extracellular domains are homologous with known C-type lectins. We have isolated and expressed a member of the NKR-P1 gene family (mNKR-P1.9) and have demonstrated both by immunofluorescence and by immunoprecipitation that this cDNA encodes NK1.1. These findings, which demonstrate the receptor-like structure of NK1.1, will facilitate studies regarding the role of NK1.1 in natural killing and regarding the identification of possible NK1.1 ligands. |
| doi_str_mv | 10.4049/jimmunol.149.5.1631 |
| format | Article |
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NK1.1 has been mapped to a chromosomal region that encodes two families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encode type II integral membrane proteins whose extracellular domains are homologous with known C-type lectins. We have isolated and expressed a member of the NKR-P1 gene family (mNKR-P1.9) and have demonstrated both by immunofluorescence and by immunoprecipitation that this cDNA encodes NK1.1. These findings, which demonstrate the receptor-like structure of NK1.1, will facilitate studies regarding the role of NK1.1 in natural killing and regarding the identification of possible NK1.1 ligands.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.149.5.1631</identifier><identifier>PMID: 1506685</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; cDNA ; Cloning, Molecular ; DNA - chemistry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; genes ; Immunobiology ; Isoantigens - analysis ; Isoantigens - genetics ; Isoantigens - physiology ; Killer Cells, Natural - immunology ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; man ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; natural killer cells ; NK1.1 antigen ; nucleotide sequence ; predictions</subject><ispartof>The Journal of immunology (1950), 1992-09, Vol.149 (5), p.1631-1635</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-805856466eaeb57bfd583c1af919b676911dece26c2413e8aedd1f8809dc72e53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4398033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1506685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryan, JC</creatorcontrib><creatorcontrib>Turck, J</creatorcontrib><creatorcontrib>Niemi, EC</creatorcontrib><creatorcontrib>Yokoyama, WM</creatorcontrib><creatorcontrib>Seaman, WE</creatorcontrib><title>Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>In mice, the NK1.1 alloantigen is expressed on all NK cells and it initiates transmembrane signals that activate cytotoxicity. NK1.1 has been mapped to a chromosomal region that encodes two families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encode type II integral membrane proteins whose extracellular domains are homologous with known C-type lectins. We have isolated and expressed a member of the NKR-P1 gene family (mNKR-P1.9) and have demonstrated both by immunofluorescence and by immunoprecipitation that this cDNA encodes NK1.1. These findings, which demonstrate the receptor-like structure of NK1.1, will facilitate studies regarding the role of NK1.1 in natural killing and regarding the identification of possible NK1.1 ligands.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>cDNA</subject><subject>Cloning, Molecular</subject><subject>DNA - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>genes</subject><subject>Immunobiology</subject><subject>Isoantigens - analysis</subject><subject>Isoantigens - genetics</subject><subject>Isoantigens - physiology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</subject><subject>man</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>natural killer cells</subject><subject>NK1.1 antigen</subject><subject>nucleotide sequence</subject><subject>predictions</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhFyAkHxBcmuCJYyc5VhVQRPkQgrM1cSa7LnbS2gmr_nuyykK5cbLk95l3RnoYew4iL0XZvLl2IczD6HMom1zloCU8YBtQSmRaC_2QbYQoigwqXT1mT1K6FkJoUZQn7ASU0LpWG3b7afRkZ4-RWz8ObtjysefTjvjnj5ADx2FyWxrOOPJAoaV4H3_LvgLvMTh_d_gccJojev7Teb9glrznaCf3Cyc3Djyseyg9ZY969ImeHd9T9uPd2-8Xl9nVl_cfLs6vMquEnLJaqFrpUmtCalXV9p2qpQXsG2haXekGoCNLhbZFCZJqpK6Dvq5F09mqICVP2au19yaOtzOlyQSXDlfhQOOcTCVBikYX_wVBL2eUUC2gXEEbx5Qi9eYmuoDxzoAwByPmjxGzGDHKHIwsUy-O9XMbqLufWRUs-ctjjsmi7yMO1qW_WCmbWki5YK9XbOe2u72LZFJA75dSMPv9_p-FvwGHn6Ly</recordid><startdate>19920901</startdate><enddate>19920901</enddate><creator>Ryan, JC</creator><creator>Turck, J</creator><creator>Niemi, EC</creator><creator>Yokoyama, WM</creator><creator>Seaman, WE</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19920901</creationdate><title>Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules</title><author>Ryan, JC ; Turck, J ; Niemi, EC ; Yokoyama, WM ; Seaman, WE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-805856466eaeb57bfd583c1af919b676911dece26c2413e8aedd1f8809dc72e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>cDNA</topic><topic>Cloning, Molecular</topic><topic>DNA - chemistry</topic><topic>Fundamental and applied biological sciences. 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NK1.1 has been mapped to a chromosomal region that encodes two families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encode type II integral membrane proteins whose extracellular domains are homologous with known C-type lectins. We have isolated and expressed a member of the NKR-P1 gene family (mNKR-P1.9) and have demonstrated both by immunofluorescence and by immunoprecipitation that this cDNA encodes NK1.1. These findings, which demonstrate the receptor-like structure of NK1.1, will facilitate studies regarding the role of NK1.1 in natural killing and regarding the identification of possible NK1.1 ligands.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>1506685</pmid><doi>10.4049/jimmunol.149.5.1631</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences cDNA Cloning, Molecular DNA - chemistry Fundamental and applied biological sciences. Psychology Fundamental immunology genes Immunobiology Isoantigens - analysis Isoantigens - genetics Isoantigens - physiology Killer Cells, Natural - immunology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation man Mice Mice, Inbred C57BL Molecular Sequence Data natural killer cells NK1.1 antigen nucleotide sequence predictions |
| title | Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules |
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