On A Four-Dimensional Representation of DNA Primary Sequences
We consider a four-dimensional representation of DNA primary sequences by assigning to each of the four basic amino acids A, T, G, C directions along the four orthogonal coordinate axes. Advantages and limitations of the novel representation of DNA primary sequences are discussed, and the use of the...
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| Veröffentlicht in: | Journal of Chemical Information and Computer Sciences 2003-03, Vol.43 (2), p.532-539 |
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| container_title | Journal of Chemical Information and Computer Sciences |
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| creator | Randić, Milan Balaban, Alexandru T |
| description | We consider a four-dimensional representation of DNA primary sequences by assigning to each of the four basic amino acids A, T, G, C directions along the four orthogonal coordinate axes. Advantages and limitations of the novel representation of DNA primary sequences are discussed, and the use of the 4-D representation is illustrated by constructing novel sequence invariants. Comparisons with the similarity/dissimilarity results based on 2-D and 3-D representations for a set of eight short DNA sequences corresponding to the first exon of beta globin in eight species, including human, are considered to illustrate the use of our novel sequence invariants based on the entries in derived sequence matrices restricted to a selected width of a band along the main diagonal. |
| doi_str_mv | 10.1021/ci020051a |
| format | Article |
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Advantages and limitations of the novel representation of DNA primary sequences are discussed, and the use of the 4-D representation is illustrated by constructing novel sequence invariants. Comparisons with the similarity/dissimilarity results based on 2-D and 3-D representations for a set of eight short DNA sequences corresponding to the first exon of beta globin in eight species, including human, are considered to illustrate the use of our novel sequence invariants based on the entries in derived sequence matrices restricted to a selected width of a band along the main diagonal.</description><identifier>ISSN: 0095-2338</identifier><identifier>EISSN: 1549-960X</identifier><identifier>EISSN: 1520-5142</identifier><identifier>DOI: 10.1021/ci020051a</identifier><identifier>PMID: 12653518</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Base Sequence ; Databases, Factual ; DNA - chemistry ; Exons ; Globins - genetics ; Humans ; Molecular Sequence Data ; Regression Analysis ; Sequence Analysis, DNA - methods ; Sequence Homology, Nucleic Acid</subject><ispartof>Journal of Chemical Information and Computer Sciences, 2003-03, Vol.43 (2), p.532-539</ispartof><rights>Copyright © 2003 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a349t-a12d5f17d2ea2da741517569ac56fa7537f35db8ed5897cc7bf252ad38fc904a3</citedby><cites>FETCH-LOGICAL-a349t-a12d5f17d2ea2da741517569ac56fa7537f35db8ed5897cc7bf252ad38fc904a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ci020051a$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ci020051a$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12653518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Randić, Milan</creatorcontrib><creatorcontrib>Balaban, Alexandru T</creatorcontrib><title>On A Four-Dimensional Representation of DNA Primary Sequences</title><title>Journal of Chemical Information and Computer Sciences</title><addtitle>J. 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Comparisons with the similarity/dissimilarity results based on 2-D and 3-D representations for a set of eight short DNA sequences corresponding to the first exon of beta globin in eight species, including human, are considered to illustrate the use of our novel sequence invariants based on the entries in derived sequence matrices restricted to a selected width of a band along the main diagonal.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Databases, Factual</subject><subject>DNA - chemistry</subject><subject>Exons</subject><subject>Globins - genetics</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Regression Analysis</subject><subject>Sequence Analysis, DNA - methods</subject><subject>Sequence Homology, Nucleic Acid</subject><issn>0095-2338</issn><issn>1549-960X</issn><issn>1520-5142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1Lw0AQhhdRbK0e_AOSi4KH6H5kd5ODh9JaK5S2thW8LdPNLqSmSd1NQP-9KSn14mlg5uF9hweha4IfCKbkUWeYYswJnKAu4VESJgJ_nKIuxgkPKWNxB114v8GYsUTQc9QhVHDGSdxFT7Mi6AejsnbhMNuawmdlAXmwMDtnvCkqqJpFUNpgOO0Hc5dtwf0ES_NVm0Ibf4nOLOTeXB1mD72PnleDcTiZvbwO-pMQWJRUIRCacktkSg3QFGREOJFcJKC5sCA5k5bxdB2blMeJ1FquLeUUUhZbneAIWA_dtbk7VzbVvlLbzGuT51CYsvZKMsKwIKIB71tQu9J7Z6zatT8rgtXelTq6atibQ2i93pr0jzzIaYCwBTJfme_jHdynEpJJrlbzpZq-LZbj4ShWe_625UF7tWmUNib9P8W_gmt-BA</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Randić, Milan</creator><creator>Balaban, Alexandru T</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>On A Four-Dimensional Representation of DNA Primary Sequences</title><author>Randić, Milan ; Balaban, Alexandru T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a349t-a12d5f17d2ea2da741517569ac56fa7537f35db8ed5897cc7bf252ad38fc904a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Databases, Factual</topic><topic>DNA - chemistry</topic><topic>Exons</topic><topic>Globins - genetics</topic><topic>Humans</topic><topic>Molecular Sequence Data</topic><topic>Regression Analysis</topic><topic>Sequence Analysis, DNA - methods</topic><topic>Sequence Homology, Nucleic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Randić, Milan</creatorcontrib><creatorcontrib>Balaban, Alexandru T</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chemical Information and Computer Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Randić, Milan</au><au>Balaban, Alexandru T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On A Four-Dimensional Representation of DNA Primary Sequences</atitle><jtitle>Journal of Chemical Information and Computer Sciences</jtitle><addtitle>J. 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| issn | 0095-2338 1549-960X 1520-5142 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Base Sequence Databases, Factual DNA - chemistry Exons Globins - genetics Humans Molecular Sequence Data Regression Analysis Sequence Analysis, DNA - methods Sequence Homology, Nucleic Acid |
| title | On A Four-Dimensional Representation of DNA Primary Sequences |
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