Effect of exercise mode on blood glucose disposal during physiological hyperinsulinaemia in humans
The aim of this study was to compare whole-body glucose uptake in cycling and running performed during physiological hyperinsulinaemia. On three occasions, seven male subjects underwent a hyperinsulinaemic (30 mU m(-2) min(-1)), euglycaemic (5 mmol l(-1)) clamp for 120 min. On one occasion, subjects...
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| Veröffentlicht in: | European journal of applied physiology 2003-04, Vol.89 (2), p.217-220 |
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| creator | Tsintzas, K Simpson, E J Seevaratnam, N Jones, S |
| description | The aim of this study was to compare whole-body glucose uptake in cycling and running performed during physiological hyperinsulinaemia. On three occasions, seven male subjects underwent a hyperinsulinaemic (30 mU m(-2) min(-1)), euglycaemic (5 mmol l(-1)) clamp for 120 min. On one occasion, subjects rested for the duration of the trial (CON). On the other two occasions, after an initial resting period of 30 min, subjects either cycled (CYC) or ran (RUN) for 90 min at 65% of maximal O(2) uptake (VO(2max)). Insulin infusion resulted in physiological hyperinsulinaemia that was maintained for the duration of each trial [CON: 61 (3) mU l(-1); CYC: 77 (7) mU l(-1); RUN: 77 (5) mU l(-1)]. The rate of glucose uptake was greater during RUN than during CYC [last 30 min of exercise: 140 (4) vs 109 (8) micromol kg(-1) min(-1), respectively; P |
| doi_str_mv | 10.1007/s00421-002-0781-3 |
| format | Article |
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On three occasions, seven male subjects underwent a hyperinsulinaemic (30 mU m(-2) min(-1)), euglycaemic (5 mmol l(-1)) clamp for 120 min. On one occasion, subjects rested for the duration of the trial (CON). On the other two occasions, after an initial resting period of 30 min, subjects either cycled (CYC) or ran (RUN) for 90 min at 65% of maximal O(2) uptake (VO(2max)). Insulin infusion resulted in physiological hyperinsulinaemia that was maintained for the duration of each trial [CON: 61 (3) mU l(-1); CYC: 77 (7) mU l(-1); RUN: 77 (5) mU l(-1)]. The rate of glucose uptake was greater during RUN than during CYC [last 30 min of exercise: 140 (4) vs 109 (8) micromol kg(-1) min(-1), respectively; P <0.01]. A differential amount of active muscle mass and/or muscle fibre type recruitment might account for the observed differences in glucose disposal between cycling and running.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-002-0781-3</identifier><identifier>PMID: 12665988</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Bicycling - physiology ; Blood Glucose - analysis ; Fasting - blood ; Glucose ; Glucose - metabolism ; Humans ; Hyperinsulinism - blood ; Infusions, Intravenous ; Insulin ; Insulin - administration & dosage ; Male ; Physiology ; Running - physiology ; Time Factors ; Variance analysis</subject><ispartof>European journal of applied physiology, 2003-04, Vol.89 (2), p.217-220</ispartof><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-233ccd7b19b374b91f3a53ab9425d53f3192390b5c11bd826dac492861637bd23</citedby><cites>FETCH-LOGICAL-c421t-233ccd7b19b374b91f3a53ab9425d53f3192390b5c11bd826dac492861637bd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12665988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsintzas, K</creatorcontrib><creatorcontrib>Simpson, E J</creatorcontrib><creatorcontrib>Seevaratnam, N</creatorcontrib><creatorcontrib>Jones, S</creatorcontrib><title>Effect of exercise mode on blood glucose disposal during physiological hyperinsulinaemia in humans</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><description>The aim of this study was to compare whole-body glucose uptake in cycling and running performed during physiological hyperinsulinaemia. On three occasions, seven male subjects underwent a hyperinsulinaemic (30 mU m(-2) min(-1)), euglycaemic (5 mmol l(-1)) clamp for 120 min. On one occasion, subjects rested for the duration of the trial (CON). On the other two occasions, after an initial resting period of 30 min, subjects either cycled (CYC) or ran (RUN) for 90 min at 65% of maximal O(2) uptake (VO(2max)). Insulin infusion resulted in physiological hyperinsulinaemia that was maintained for the duration of each trial [CON: 61 (3) mU l(-1); CYC: 77 (7) mU l(-1); RUN: 77 (5) mU l(-1)]. The rate of glucose uptake was greater during RUN than during CYC [last 30 min of exercise: 140 (4) vs 109 (8) micromol kg(-1) min(-1), respectively; P <0.01]. A differential amount of active muscle mass and/or muscle fibre type recruitment might account for the observed differences in glucose disposal between cycling and running.</description><subject>Adult</subject><subject>Bicycling - physiology</subject><subject>Blood Glucose - analysis</subject><subject>Fasting - blood</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Hyperinsulinism - blood</subject><subject>Infusions, Intravenous</subject><subject>Insulin</subject><subject>Insulin - administration & dosage</subject><subject>Male</subject><subject>Physiology</subject><subject>Running - physiology</subject><subject>Time Factors</subject><subject>Variance analysis</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1qGzEUhUVJqR23D9BNEVl0N6mu7vxIy2KcJmDIpl0L_Y0tMzOajjwQv31kbFrIJiCQOHz3isNHyFdg98BY8yMxVnIoGOMFawQU-IEsoURZ1Mibm39vkAtym9KBMSY4iE9kAbyuKynEkphN23p7pLGl_sVPNiRP--g8jQM1XYyO7rrZxpy6kMaYdEfdPIVhR8f9KYXYxV2wOdyfRp_jNHdh0L4PmoaB7udeD-kz-djqLvkv13tF_jxsfq8fi-3zr6f1z21hc4ljwRGtdY0BabApjYQWdYXayJJXrsI21-AomaksgHGC107bUnJRQ42NcRxX5Ptl7zjFv7NPR9WHZH3X6cHHOakGgUsU8l0QRFNmjGXw7g14iPM05BIqf1tChfmsCFwgO8WUJt-qcQq9nk4KmDprUhdNKmtSZ00K88y36-LZ9N79n7h6wVckEo16</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Tsintzas, K</creator><creator>Simpson, E J</creator><creator>Seevaratnam, N</creator><creator>Jones, S</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Effect of exercise mode on blood glucose disposal during physiological hyperinsulinaemia in humans</title><author>Tsintzas, K ; 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On three occasions, seven male subjects underwent a hyperinsulinaemic (30 mU m(-2) min(-1)), euglycaemic (5 mmol l(-1)) clamp for 120 min. On one occasion, subjects rested for the duration of the trial (CON). On the other two occasions, after an initial resting period of 30 min, subjects either cycled (CYC) or ran (RUN) for 90 min at 65% of maximal O(2) uptake (VO(2max)). Insulin infusion resulted in physiological hyperinsulinaemia that was maintained for the duration of each trial [CON: 61 (3) mU l(-1); CYC: 77 (7) mU l(-1); RUN: 77 (5) mU l(-1)]. The rate of glucose uptake was greater during RUN than during CYC [last 30 min of exercise: 140 (4) vs 109 (8) micromol kg(-1) min(-1), respectively; P <0.01]. 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| subjects | Adult Bicycling - physiology Blood Glucose - analysis Fasting - blood Glucose Glucose - metabolism Humans Hyperinsulinism - blood Infusions, Intravenous Insulin Insulin - administration & dosage Male Physiology Running - physiology Time Factors Variance analysis |
| title | Effect of exercise mode on blood glucose disposal during physiological hyperinsulinaemia in humans |
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