HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients
To investigate the association between autoimmune hepatitis and HLA alleles in Japanese patients, serological typing and class II genotyping were performed using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. Serological typing showed that HLA-B54, -DR4, -...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1992-09, Vol.103 (3), p.1041-1047 |
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| creator | Seki, Takeshi Ota, Masao Furuta, Seiichi Fukushima, Hirohumi Kondo, Toshiro Hino, Kunihiko Mizuki, Nobuhisa Ando, Asako Tsuji, Kimiyoshi Inoko, Hidetoshi Kiyosawa, Kendo |
| description | To investigate the association between autoimmune hepatitis and HLA alleles in Japanese patients, serological typing and class II genotyping were performed using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. Serological typing showed that HLA-B54, -DR4, -DR53, and -DQ4 were significantly more frequent in patients with autoimmune hepatitis than in controls. HLA-DR4 was most frequently associated with autoimmune hepatitis (88.7%). In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls. However, there was no significant difference in the frequency of Dw between the patients and the controls who were DR4-positive. The significant increase observed in DQA1*0301 and DQB1*0401 was explained by a linkage disequilibrium with DR4. Six DR4-negative patients had DR2, but there was no significant difference in the frequency of the DR2-associated Dwalleles compared with the DR2-positive controls. No DPB1 allele was significantly associated with autoimmune hepatitis. These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese. |
| doi_str_mv | 10.1016/0016-5085(92)90041-V |
| format | Article |
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Serological typing showed that HLA-B54, -DR4, -DR53, and -DQ4 were significantly more frequent in patients with autoimmune hepatitis than in controls. HLA-DR4 was most frequently associated with autoimmune hepatitis (88.7%). In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls. However, there was no significant difference in the frequency of Dw between the patients and the controls who were DR4-positive. The significant increase observed in DQA1*0301 and DQB1*0401 was explained by a linkage disequilibrium with DR4. Six DR4-negative patients had DR2, but there was no significant difference in the frequency of the DR2-associated Dwalleles compared with the DR2-positive controls. No DPB1 allele was significantly associated with autoimmune hepatitis. These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(92)90041-V</identifier><identifier>PMID: 1354193</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Alleles ; Autoimmune Diseases - ethnology ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Biomarkers ; Disease Susceptibility ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Frequency ; Genotype ; Hepatitis, Chronic - ethnology ; Hepatitis, Chronic - immunology ; Histocompatibility Antigens Class II - genetics ; HLA-DQ Antigens - genetics ; HLA-DQ beta-Chains ; HLA-DR4 Antigen - genetics ; Humans ; Japan ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1992-09, Vol.103 (3), p.1041-1047</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-3dc0f5344139179af6f3295ad1b05be33c2285e732b55bf76b0822a819adea8b3</citedby><cites>FETCH-LOGICAL-c437t-3dc0f5344139179af6f3295ad1b05be33c2285e732b55bf76b0822a819adea8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0016-5085(92)90041-V$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4355674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1354193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seki, Takeshi</creatorcontrib><creatorcontrib>Ota, Masao</creatorcontrib><creatorcontrib>Furuta, Seiichi</creatorcontrib><creatorcontrib>Fukushima, Hirohumi</creatorcontrib><creatorcontrib>Kondo, Toshiro</creatorcontrib><creatorcontrib>Hino, Kunihiko</creatorcontrib><creatorcontrib>Mizuki, Nobuhisa</creatorcontrib><creatorcontrib>Ando, Asako</creatorcontrib><creatorcontrib>Tsuji, Kimiyoshi</creatorcontrib><creatorcontrib>Inoko, Hidetoshi</creatorcontrib><creatorcontrib>Kiyosawa, Kendo</creatorcontrib><title>HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>To investigate the association between autoimmune hepatitis and HLA alleles in Japanese patients, serological typing and class II genotyping were performed using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. Serological typing showed that HLA-B54, -DR4, -DR53, and -DQ4 were significantly more frequent in patients with autoimmune hepatitis than in controls. HLA-DR4 was most frequently associated with autoimmune hepatitis (88.7%). In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls. However, there was no significant difference in the frequency of Dw between the patients and the controls who were DR4-positive. The significant increase observed in DQA1*0301 and DQB1*0401 was explained by a linkage disequilibrium with DR4. Six DR4-negative patients had DR2, but there was no significant difference in the frequency of the DR2-associated Dwalleles compared with the DR2-positive controls. No DPB1 allele was significantly associated with autoimmune hepatitis. These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Autoimmune Diseases - ethnology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Hepatitis, Chronic - ethnology</subject><subject>Hepatitis, Chronic - immunology</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ beta-Chains</subject><subject>HLA-DR4 Antigen - genetics</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKBDEQRYMoOj7-QCELEV205tGZ7mwEGXyMDLhQZxvS6WqM9MuutODfm3EG3bmpWtxTxeUQcszZJWd8esXiSBTL1bkWF5qxlCfLLTLhSuRJzMQ2mfwie2Qf8Z0xpmXOd8kulyrlWk7I88PihrraItL5nDZdDW6sAaltS2rH0PmmGVugb9Db4INHiiM66IMvfO3DF_UtfbS9bQGBrhBoAx6SncrWCEebfUBe725fZg_J4ul-PrtZJC6VWUhk6VilZJpyqXmmbTWtpNDKlrxgqgApnRC5gkyKQqmiyqYFy4WwOde2BJsX8oCcrf_2Q_cxAgbT-FiurmOdbkSTSS50NBDBdA26oUMcoDL94Bs7fBnOzMqlWYkyK1FGC_Pj0izj2cnm_1g0UP4dreXF_HSTW3S2rgbbOo-_WCqVmmZpxK7XGEQXnx4Ggy56clD6AVwwZef_7_EN0OWPuA</recordid><startdate>19920901</startdate><enddate>19920901</enddate><creator>Seki, Takeshi</creator><creator>Ota, Masao</creator><creator>Furuta, Seiichi</creator><creator>Fukushima, Hirohumi</creator><creator>Kondo, Toshiro</creator><creator>Hino, Kunihiko</creator><creator>Mizuki, Nobuhisa</creator><creator>Ando, Asako</creator><creator>Tsuji, Kimiyoshi</creator><creator>Inoko, Hidetoshi</creator><creator>Kiyosawa, Kendo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920901</creationdate><title>HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients</title><author>Seki, Takeshi ; Ota, Masao ; Furuta, Seiichi ; Fukushima, Hirohumi ; Kondo, Toshiro ; Hino, Kunihiko ; Mizuki, Nobuhisa ; Ando, Asako ; Tsuji, Kimiyoshi ; Inoko, Hidetoshi ; Kiyosawa, Kendo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-3dc0f5344139179af6f3295ad1b05be33c2285e732b55bf76b0822a819adea8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Autoimmune Diseases - ethnology</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Hepatitis, Chronic - ethnology</topic><topic>Hepatitis, Chronic - immunology</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ beta-Chains</topic><topic>HLA-DR4 Antigen - genetics</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seki, Takeshi</creatorcontrib><creatorcontrib>Ota, Masao</creatorcontrib><creatorcontrib>Furuta, Seiichi</creatorcontrib><creatorcontrib>Fukushima, Hirohumi</creatorcontrib><creatorcontrib>Kondo, Toshiro</creatorcontrib><creatorcontrib>Hino, Kunihiko</creatorcontrib><creatorcontrib>Mizuki, Nobuhisa</creatorcontrib><creatorcontrib>Ando, Asako</creatorcontrib><creatorcontrib>Tsuji, Kimiyoshi</creatorcontrib><creatorcontrib>Inoko, Hidetoshi</creatorcontrib><creatorcontrib>Kiyosawa, Kendo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seki, Takeshi</au><au>Ota, Masao</au><au>Furuta, Seiichi</au><au>Fukushima, Hirohumi</au><au>Kondo, Toshiro</au><au>Hino, Kunihiko</au><au>Mizuki, Nobuhisa</au><au>Ando, Asako</au><au>Tsuji, Kimiyoshi</au><au>Inoko, Hidetoshi</au><au>Kiyosawa, Kendo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1992-09-01</date><risdate>1992</risdate><volume>103</volume><issue>3</issue><spage>1041</spage><epage>1047</epage><pages>1041-1047</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>To investigate the association between autoimmune hepatitis and HLA alleles in Japanese patients, serological typing and class II genotyping were performed using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. Serological typing showed that HLA-B54, -DR4, -DR53, and -DQ4 were significantly more frequent in patients with autoimmune hepatitis than in controls. HLA-DR4 was most frequently associated with autoimmune hepatitis (88.7%). In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls. However, there was no significant difference in the frequency of Dw between the patients and the controls who were DR4-positive. The significant increase observed in DQA1*0301 and DQB1*0401 was explained by a linkage disequilibrium with DR4. Six DR4-negative patients had DR2, but there was no significant difference in the frequency of the DR2-associated Dwalleles compared with the DR2-positive controls. No DPB1 allele was significantly associated with autoimmune hepatitis. These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1354193</pmid><doi>10.1016/0016-5085(92)90041-V</doi><tpages>7</tpages></addata></record> |
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| ispartof | Gastroenterology (New York, N.Y. 1943), 1992-09, Vol.103 (3), p.1041-1047 |
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| subjects | Adult Aged Alleles Autoimmune Diseases - ethnology Autoimmune Diseases - immunology Biological and medical sciences Biomarkers Disease Susceptibility Female Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genotype Hepatitis, Chronic - ethnology Hepatitis, Chronic - immunology Histocompatibility Antigens Class II - genetics HLA-DQ Antigens - genetics HLA-DQ beta-Chains HLA-DR4 Antigen - genetics Humans Japan Male Medical sciences Middle Aged Polymerase Chain Reaction Polymorphism, Restriction Fragment Length |
| title | HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients |
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