Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study
Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been associated with poor dietary fish or n-3 PUFA intake, and low docosahexaenoic acid (DHA) status. The present case–control study used an establi...
Gespeichert in:
| Veröffentlicht in: | British journal of nutrition 2003-04, Vol.89 (4), p.483-489 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 489 |
|---|---|
| container_issue | 4 |
| container_start_page | 483 |
| container_title | British journal of nutrition |
| container_volume | 89 |
| creator | Tully, A. M. Roche, H. M. Doyle, R. Fallon, C. Bruce, I. Lawlor, B. Coakley, D. Gibney, M. J. |
| description | Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been associated with poor dietary fish or n-3 PUFA intake, and low docosahexaenoic acid (DHA) status. The present case–control study used an established biomarker of n-3 PUFA intake (serum cholesteryl ester-fatty acid composition) to determine n-3 PUFA status in patients with Alzheimer's disease, who were free-living in the community. All cases fulfilled the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association criteria for Alzheimer's disease. Detailed neuropsychological testing and neuroimaging established the diagnosis in all cases. The subjects (119 females and twenty-nine males) aged 76·5 (SD 6·6) YEARS HAD A CLINICAL DEMENTIA RATING (CDR) OF 1 (sd 0·62) and a mini mental state examination (MMSE) score of 19·5 (sd 4·8). The control subjects (thirty-six females and nine males) aged 70 (sd 6·0) years were not cognitively impaired (defined as MMSE score |
| doi_str_mv | 10.1079/BJN2002804 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73126828</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1079_BJN2002804</cupid><sourcerecordid>1453941851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c548t-18f45380b3f40f5a0cb12bb799c99560fa2e45fc00aa018a3f58ea648c77742f3</originalsourceid><addsrcrecordid>eNqF0c2KFDEUBeBCFKcd3fgAEgQVxNKbVP7K3TjoqLQjA7pxE1KpxM6YqoxJl0678h18Q5_EtF3YIIKrS8jH5R5OVd3G8BiDaJ88e31KAIgEeqVaYCpYTTgnV6sFAIgaY8oOqhs5n5enxNBerw4w4YxizheVW8avKNs0DcisYrB5bdMmoN-z7qOJWa_spbZj9AZp43sU7BcbMvIjOgrfVtYPNj3IqPfZ6myfIo1MmT-__zBxXKcYUF5P_eZmdc3pkO2teR5W7188f3f8sl6-PXl1fLSsDaNyXWPpKGskdI2j4JgG02HSdaJtTdsyDk4TS5kzAFoDlrpxTFrNqTRCCEpcc1jd3-29SPHzVFKowWdjQ9CjjVNWoinRJZH_hbhlQCnQAu_-Bc_jlMYSQhHcyEYwvEUPd8ikmHOyTl0kP-i0URjUtiO176jgO_PGqRtsv6dzKQXcm4HORgeX9Gh83jsqGi6a7aJ653xp6_LPv06fVPkXTPGTMwWnbyRfnhH1ofhH85V66JLvP9p9ln_c-QuiObYO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213837514</pqid></control><display><type>article</type><title>Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Tully, A. M. ; Roche, H. M. ; Doyle, R. ; Fallon, C. ; Bruce, I. ; Lawlor, B. ; Coakley, D. ; Gibney, M. J.</creator><creatorcontrib>Tully, A. M. ; Roche, H. M. ; Doyle, R. ; Fallon, C. ; Bruce, I. ; Lawlor, B. ; Coakley, D. ; Gibney, M. J.</creatorcontrib><description>Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been associated with poor dietary fish or n-3 PUFA intake, and low docosahexaenoic acid (DHA) status. The present case–control study used an established biomarker of n-3 PUFA intake (serum cholesteryl ester-fatty acid composition) to determine n-3 PUFA status in patients with Alzheimer's disease, who were free-living in the community. All cases fulfilled the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association criteria for Alzheimer's disease. Detailed neuropsychological testing and neuroimaging established the diagnosis in all cases. The subjects (119 females and twenty-nine males) aged 76·5 (SD 6·6) YEARS HAD A CLINICAL DEMENTIA RATING (CDR) OF 1 (sd 0·62) and a mini mental state examination (MMSE) score of 19·5 (sd 4·8). The control subjects (thirty-six females and nine males) aged 70 (sd 6·0) years were not cognitively impaired (defined as MMSE score <24): they had a mean MMSE score of 28·9 (sd 1·1). Serum cholesteryl ester-eicosapentaenoic acid and DHA levels were significantly lower (P<0·05 and P<0·001 respectively) in all MMSE score quartiles of patients with Alzheimer's disease compared with control values. Serum cholesteryl ester-DHA levels were progressively reduced with severity of clinical dementia. DHA levels did not differ in patients with Alzheimer's disease across age quartiles: all were consistently lower than in control subjects. Step-wise multiple regression analysis showed that cholesteryl ester-DHA and total saturated fatty acid levels were the important determinants of MMSE score and CDR. It remains to be determined whether low DHA status in Alzheimer's disease is a casual factor in the pathogenesis and progression of Alzheimer's disease.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN2002804</identifier><identifier>PMID: 12654166</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Alzheimer Disease - blood ; Alzheimer's disease ; Analysis of Variance ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Case studies ; Case-Control Studies ; Cholesterol Esters - blood ; Cognitive ability ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Dementia disorders ; Disease ; Docosahexaenoic acid ; Docosahexaenoic Acids - blood ; Fatty acids ; Fatty Acids - blood ; Fatty Acids, Omega-3 - blood ; Female ; Humans ; Industrialized nations ; Male ; Medical imaging ; Medical sciences ; n-3 Polyunsaturated fatty acids ; Neuroimaging ; Neurology ; Neuropsychology ; Nutrition ; Nutritional Status ; Older people ; Polyunsaturated fatty acids ; Regression Analysis</subject><ispartof>British journal of nutrition, 2003-04, Vol.89 (4), p.483-489</ispartof><rights>Copyright © The Nutrition Society 2003</rights><rights>2003 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-18f45380b3f40f5a0cb12bb799c99560fa2e45fc00aa018a3f58ea648c77742f3</citedby><cites>FETCH-LOGICAL-c548t-18f45380b3f40f5a0cb12bb799c99560fa2e45fc00aa018a3f58ea648c77742f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14736734$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12654166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tully, A. M.</creatorcontrib><creatorcontrib>Roche, H. M.</creatorcontrib><creatorcontrib>Doyle, R.</creatorcontrib><creatorcontrib>Fallon, C.</creatorcontrib><creatorcontrib>Bruce, I.</creatorcontrib><creatorcontrib>Lawlor, B.</creatorcontrib><creatorcontrib>Coakley, D.</creatorcontrib><creatorcontrib>Gibney, M. J.</creatorcontrib><title>Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been associated with poor dietary fish or n-3 PUFA intake, and low docosahexaenoic acid (DHA) status. The present case–control study used an established biomarker of n-3 PUFA intake (serum cholesteryl ester-fatty acid composition) to determine n-3 PUFA status in patients with Alzheimer's disease, who were free-living in the community. All cases fulfilled the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association criteria for Alzheimer's disease. Detailed neuropsychological testing and neuroimaging established the diagnosis in all cases. The subjects (119 females and twenty-nine males) aged 76·5 (SD 6·6) YEARS HAD A CLINICAL DEMENTIA RATING (CDR) OF 1 (sd 0·62) and a mini mental state examination (MMSE) score of 19·5 (sd 4·8). The control subjects (thirty-six females and nine males) aged 70 (sd 6·0) years were not cognitively impaired (defined as MMSE score <24): they had a mean MMSE score of 28·9 (sd 1·1). Serum cholesteryl ester-eicosapentaenoic acid and DHA levels were significantly lower (P<0·05 and P<0·001 respectively) in all MMSE score quartiles of patients with Alzheimer's disease compared with control values. Serum cholesteryl ester-DHA levels were progressively reduced with severity of clinical dementia. DHA levels did not differ in patients with Alzheimer's disease across age quartiles: all were consistently lower than in control subjects. Step-wise multiple regression analysis showed that cholesteryl ester-DHA and total saturated fatty acid levels were the important determinants of MMSE score and CDR. It remains to be determined whether low DHA status in Alzheimer's disease is a casual factor in the pathogenesis and progression of Alzheimer's disease.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - blood</subject><subject>Alzheimer's disease</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Case studies</subject><subject>Case-Control Studies</subject><subject>Cholesterol Esters - blood</subject><subject>Cognitive ability</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Disease</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - blood</subject><subject>Fatty acids</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids, Omega-3 - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Industrialized nations</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>n-3 Polyunsaturated fatty acids</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuropsychology</subject><subject>Nutrition</subject><subject>Nutritional Status</subject><subject>Older people</subject><subject>Polyunsaturated fatty acids</subject><subject>Regression Analysis</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c2KFDEUBeBCFKcd3fgAEgQVxNKbVP7K3TjoqLQjA7pxE1KpxM6YqoxJl0678h18Q5_EtF3YIIKrS8jH5R5OVd3G8BiDaJ88e31KAIgEeqVaYCpYTTgnV6sFAIgaY8oOqhs5n5enxNBerw4w4YxizheVW8avKNs0DcisYrB5bdMmoN-z7qOJWa_spbZj9AZp43sU7BcbMvIjOgrfVtYPNj3IqPfZ6myfIo1MmT-__zBxXKcYUF5P_eZmdc3pkO2teR5W7188f3f8sl6-PXl1fLSsDaNyXWPpKGskdI2j4JgG02HSdaJtTdsyDk4TS5kzAFoDlrpxTFrNqTRCCEpcc1jd3-29SPHzVFKowWdjQ9CjjVNWoinRJZH_hbhlQCnQAu_-Bc_jlMYSQhHcyEYwvEUPd8ikmHOyTl0kP-i0URjUtiO176jgO_PGqRtsv6dzKQXcm4HORgeX9Gh83jsqGi6a7aJ653xp6_LPv06fVPkXTPGTMwWnbyRfnhH1ofhH85V66JLvP9p9ln_c-QuiObYO</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Tully, A. M.</creator><creator>Roche, H. M.</creator><creator>Doyle, R.</creator><creator>Fallon, C.</creator><creator>Bruce, I.</creator><creator>Lawlor, B.</creator><creator>Coakley, D.</creator><creator>Gibney, M. J.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study</title><author>Tully, A. M. ; Roche, H. M. ; Doyle, R. ; Fallon, C. ; Bruce, I. ; Lawlor, B. ; Coakley, D. ; Gibney, M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-18f45380b3f40f5a0cb12bb799c99560fa2e45fc00aa018a3f58ea648c77742f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - blood</topic><topic>Alzheimer's disease</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Case studies</topic><topic>Case-Control Studies</topic><topic>Cholesterol Esters - blood</topic><topic>Cognitive ability</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Disease</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - blood</topic><topic>Fatty acids</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids, Omega-3 - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Industrialized nations</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>n-3 Polyunsaturated fatty acids</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neuropsychology</topic><topic>Nutrition</topic><topic>Nutritional Status</topic><topic>Older people</topic><topic>Polyunsaturated fatty acids</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tully, A. M.</creatorcontrib><creatorcontrib>Roche, H. M.</creatorcontrib><creatorcontrib>Doyle, R.</creatorcontrib><creatorcontrib>Fallon, C.</creatorcontrib><creatorcontrib>Bruce, I.</creatorcontrib><creatorcontrib>Lawlor, B.</creatorcontrib><creatorcontrib>Coakley, D.</creatorcontrib><creatorcontrib>Gibney, M. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tully, A. M.</au><au>Roche, H. M.</au><au>Doyle, R.</au><au>Fallon, C.</au><au>Bruce, I.</au><au>Lawlor, B.</au><au>Coakley, D.</au><au>Gibney, M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>89</volume><issue>4</issue><spage>483</spage><epage>489</epage><pages>483-489</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been associated with poor dietary fish or n-3 PUFA intake, and low docosahexaenoic acid (DHA) status. The present case–control study used an established biomarker of n-3 PUFA intake (serum cholesteryl ester-fatty acid composition) to determine n-3 PUFA status in patients with Alzheimer's disease, who were free-living in the community. All cases fulfilled the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association criteria for Alzheimer's disease. Detailed neuropsychological testing and neuroimaging established the diagnosis in all cases. The subjects (119 females and twenty-nine males) aged 76·5 (SD 6·6) YEARS HAD A CLINICAL DEMENTIA RATING (CDR) OF 1 (sd 0·62) and a mini mental state examination (MMSE) score of 19·5 (sd 4·8). The control subjects (thirty-six females and nine males) aged 70 (sd 6·0) years were not cognitively impaired (defined as MMSE score <24): they had a mean MMSE score of 28·9 (sd 1·1). Serum cholesteryl ester-eicosapentaenoic acid and DHA levels were significantly lower (P<0·05 and P<0·001 respectively) in all MMSE score quartiles of patients with Alzheimer's disease compared with control values. Serum cholesteryl ester-DHA levels were progressively reduced with severity of clinical dementia. DHA levels did not differ in patients with Alzheimer's disease across age quartiles: all were consistently lower than in control subjects. Step-wise multiple regression analysis showed that cholesteryl ester-DHA and total saturated fatty acid levels were the important determinants of MMSE score and CDR. It remains to be determined whether low DHA status in Alzheimer's disease is a casual factor in the pathogenesis and progression of Alzheimer's disease.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>12654166</pmid><doi>10.1079/BJN2002804</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2003-04, Vol.89 (4), p.483-489 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73126828 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Age Factors Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer's disease Analysis of Variance Biological and medical sciences Biomarkers Biomarkers - blood Case studies Case-Control Studies Cholesterol Esters - blood Cognitive ability Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia disorders Disease Docosahexaenoic acid Docosahexaenoic Acids - blood Fatty acids Fatty Acids - blood Fatty Acids, Omega-3 - blood Female Humans Industrialized nations Male Medical imaging Medical sciences n-3 Polyunsaturated fatty acids Neuroimaging Neurology Neuropsychology Nutrition Nutritional Status Older people Polyunsaturated fatty acids Regression Analysis |
| title | Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A38%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20serum%20cholesteryl%20ester-docosahexaenoic%20acid%20levels%20in%20Alzheimer's%20disease:%20a%20case%E2%80%93control%20study&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Tully,%20A.%20M.&rft.date=2003-04-01&rft.volume=89&rft.issue=4&rft.spage=483&rft.epage=489&rft.pages=483-489&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1079/BJN2002804&rft_dat=%3Cproquest_cross%3E1453941851%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213837514&rft_id=info:pmid/12654166&rft_cupid=10_1079_BJN2002804&rfr_iscdi=true |