Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex vivo for their ability to inhibit Ca II in the albino rabbit eye after topical administration. Compound 11a was found to lower intraocular p...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-08, Vol.35 (16), p.3027-3033
Hauptverfasser:	Hartman, George D, Halczenko, Wasyl, Prugh, John D, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - metabolism Chemistry Dansyl Compounds - metabolism Erythrocytes - enzymology Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Humans Intraocular Pressure - drug effects Organic chemistry Preparations and properties Rabbits Solubility Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - pharmacology
Online-Zugang:	Volltext
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