Sigma receptors in schizophrenic cerebral cortices
Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma rece...
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| Veröffentlicht in: | Neurochemical research 1992-10, Vol.17 (10), p.983-990 |
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| container_end_page | 990 |
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| container_title | Neurochemical research |
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| creator | SHIBUYA, H MORI, H TORU, M |
| description | Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1, 3, di-o-tolylguanidine (DTG) and non-specific binding of [3H]DTG was determined in the presence of 10(-5)M haloperidol. Monovalent and divalent cations strongly inhibited [3H]DTG binding. Glutamate, aspartate and glycine also decreased the binding to human cerebral membranes. With post-mortem brain samples from 12 schizophrenics and 10 controls, sigma receptors were measured in 17 areas of cerebral cortex. Sigma receptors binding showed the regional differences in the cortex, but no significant differences between schizophrenics and controls were observed except the superior parietal cortex where the binding significantly increased in the schizophrenic group. These results suggest that sigma receptors in cerebral cortices might not be directly concerned with the pathophysiological role in schizophrenia. |
| doi_str_mv | 10.1007/bf00966825 |
| format | Article |
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Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1, 3, di-o-tolylguanidine (DTG) and non-specific binding of [3H]DTG was determined in the presence of 10(-5)M haloperidol. Monovalent and divalent cations strongly inhibited [3H]DTG binding. Glutamate, aspartate and glycine also decreased the binding to human cerebral membranes. With post-mortem brain samples from 12 schizophrenics and 10 controls, sigma receptors were measured in 17 areas of cerebral cortex. Sigma receptors binding showed the regional differences in the cortex, but no significant differences between schizophrenics and controls were observed except the superior parietal cortex where the binding significantly increased in the schizophrenic group. These results suggest that sigma receptors in cerebral cortices might not be directly concerned with the pathophysiological role in schizophrenia.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/bf00966825</identifier><identifier>PMID: 1324440</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Amino Acids - pharmacology ; Animals ; Biological and medical sciences ; Cations - pharmacology ; Cerebral Cortex - chemistry ; Cerebral Cortex - drug effects ; cerebrum ; cortex ; Female ; Guanidines - metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Radioligand Assay ; Rats ; Rats, Inbred Strains ; Receptors, Opioid - analysis ; Receptors, sigma ; schizophrenia ; Schizophrenia - metabolism</subject><ispartof>Neurochemical research, 1992-10, Vol.17 (10), p.983-990</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-b8fd72ca9881d341c9f0ea665411016dca202e78e13b858a920816f8fb68463d3</citedby><cites>FETCH-LOGICAL-c408t-b8fd72ca9881d341c9f0ea665411016dca202e78e13b858a920816f8fb68463d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4482875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1324440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIBUYA, H</creatorcontrib><creatorcontrib>MORI, H</creatorcontrib><creatorcontrib>TORU, M</creatorcontrib><title>Sigma receptors in schizophrenic cerebral cortices</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1, 3, di-o-tolylguanidine (DTG) and non-specific binding of [3H]DTG was determined in the presence of 10(-5)M haloperidol. Monovalent and divalent cations strongly inhibited [3H]DTG binding. Glutamate, aspartate and glycine also decreased the binding to human cerebral membranes. With post-mortem brain samples from 12 schizophrenics and 10 controls, sigma receptors were measured in 17 areas of cerebral cortex. Sigma receptors binding showed the regional differences in the cortex, but no significant differences between schizophrenics and controls were observed except the superior parietal cortex where the binding significantly increased in the schizophrenic group. These results suggest that sigma receptors in cerebral cortices might not be directly concerned with the pathophysiological role in schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Amino Acids - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cations - pharmacology</subject><subject>Cerebral Cortex - chemistry</subject><subject>Cerebral Cortex - drug effects</subject><subject>cerebrum</subject><subject>cortex</subject><subject>Female</subject><subject>Guanidines - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Radioligand Assay</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Opioid - analysis</subject><subject>Receptors, sigma</subject><subject>schizophrenia</subject><subject>Schizophrenia - metabolism</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0D1PwzAYBGALgUopLOxIGRADUuB9bcexR1pRQKrEAMyR49jUKF_Y6QC_nqAWGJluuEc3HCGnCFcIkF-XDkAJIWm2R6aY5SwVCtg-mQITPGWo4JAcxfgGMHKKEzJBRjnnMCX0yb82OgnW2H7oQkx8m0Sz9p9dvw629SYxNtgy6DoxXRi8sfGYHDhdR3uyyxl5Wd4-L-7T1ePdw-JmlRoOckhL6aqcGq2kxIpxNMqB1UJkHBFQVEZToDaXFlkpM6kVBYnCSVcKyQWr2IxcbHf70L1vbByKxkdj61q3ttvEImdIuRL4L0TBIVdKjfByC03oYgzWFX3wjQ4fBULx_WQxX_48OeKz3eqmbGz1R7fXjf35rtfR6NoF3Roffxnnkso8Y1_tiXiX</recordid><startdate>19921001</startdate><enddate>19921001</enddate><creator>SHIBUYA, H</creator><creator>MORI, H</creator><creator>TORU, M</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19921001</creationdate><title>Sigma receptors in schizophrenic cerebral cortices</title><author>SHIBUYA, H ; MORI, H ; TORU, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-b8fd72ca9881d341c9f0ea665411016dca202e78e13b858a920816f8fb68463d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Amino Acids - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cations - pharmacology</topic><topic>Cerebral Cortex - chemistry</topic><topic>Cerebral Cortex - drug effects</topic><topic>cerebrum</topic><topic>cortex</topic><topic>Female</topic><topic>Guanidines - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Radioligand Assay</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Opioid - analysis</topic><topic>Receptors, sigma</topic><topic>schizophrenia</topic><topic>Schizophrenia - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIBUYA, H</creatorcontrib><creatorcontrib>MORI, H</creatorcontrib><creatorcontrib>TORU, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIBUYA, H</au><au>MORI, H</au><au>TORU, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sigma receptors in schizophrenic cerebral cortices</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>1992-10-01</date><risdate>1992</risdate><volume>17</volume><issue>10</issue><spage>983</spage><epage>990</epage><pages>983-990</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><coden>NEREDZ</coden><abstract>Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1, 3, di-o-tolylguanidine (DTG) and non-specific binding of [3H]DTG was determined in the presence of 10(-5)M haloperidol. Monovalent and divalent cations strongly inhibited [3H]DTG binding. Glutamate, aspartate and glycine also decreased the binding to human cerebral membranes. With post-mortem brain samples from 12 schizophrenics and 10 controls, sigma receptors were measured in 17 areas of cerebral cortex. Sigma receptors binding showed the regional differences in the cortex, but no significant differences between schizophrenics and controls were observed except the superior parietal cortex where the binding significantly increased in the schizophrenic group. These results suggest that sigma receptors in cerebral cortices might not be directly concerned with the pathophysiological role in schizophrenia.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>1324440</pmid><doi>10.1007/bf00966825</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Aged Amino Acids - pharmacology Animals Biological and medical sciences Cations - pharmacology Cerebral Cortex - chemistry Cerebral Cortex - drug effects cerebrum cortex Female Guanidines - metabolism Humans Male Medical sciences Middle Aged Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Radioligand Assay Rats Rats, Inbred Strains Receptors, Opioid - analysis Receptors, sigma schizophrenia Schizophrenia - metabolism |
| title | Sigma receptors in schizophrenic cerebral cortices |
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