Effects of Anti-Asthma Drugs and Potassium Channel Openers on Neurally-Mediated Contraction of Isolated Guinea Pig Trachea
The effects of anti-asthma drugs, isoproterenol, aminophylline and hydrocortisone, and potassium channel openers on the contraction induced by electrical stimulation or exogenously applied acetylcholine were investigated in isolated guinea pig trachea. Isoproterenol and aminophylline non-selectively...
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| Veröffentlicht in: | Japanese Journal of Pharmacology 1992, Vol.59(1), pp.129-132 |
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| creator | Yamamoto, Akiko Shikada, Ken-ichi Tanaka, Sakuya |
| description | The effects of anti-asthma drugs, isoproterenol, aminophylline and hydrocortisone, and potassium channel openers on the contraction induced by electrical stimulation or exogenously applied acetylcholine were investigated in isolated guinea pig trachea. Isoproterenol and aminophylline non-selectively inhibited both the contraction evoked by vagus nerve- and that by transmural field-stimulation, but had no effect on the response induced by exogenously applied acetylcholine. Hydrocortisone and potassium channel openers, NIP-121 and cromakalim, preferentially inhibited vagus nerve-mediated response. These results suggest that anti-asthma drugs may have an ability to inhibit neurally-mediated contraction in the guinea pig trachea. |
| doi_str_mv | 10.1254/jjp.59.129 |
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Isoproterenol and aminophylline non-selectively inhibited both the contraction evoked by vagus nerve- and that by transmural field-stimulation, but had no effect on the response induced by exogenously applied acetylcholine. Hydrocortisone and potassium channel openers, NIP-121 and cromakalim, preferentially inhibited vagus nerve-mediated response. These results suggest that anti-asthma drugs may have an ability to inhibit neurally-mediated contraction in the guinea pig trachea.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.59.129</identifier><identifier>PMID: 1507653</identifier><identifier>CODEN: JJPAAZ</identifier><language>eng</language><publisher>Kyoto: The Japanese Pharmacological Society</publisher><subject>Acetylcholine - pharmacology ; aminophylline ; Aminophylline - administration & dosage ; Aminophylline - pharmacology ; Animals ; Anti-asthma drugs ; Benzopyrans - pharmacology ; Biological and medical sciences ; contraction ; Cromakalim ; effects on ; Electric Stimulation ; Guinea Pigs ; Histamine and antagonists. Allergy ; Hydrocortisone - administration & dosage ; Hydrocortisone - pharmacology ; isoproterenol ; Isoproterenol - administration & dosage ; Isoproterenol - pharmacology ; Male ; Medical sciences ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Neurally-mediated contraction ; Oxadiazoles - pharmacology ; Pharmacology. Drug treatments ; Piperidines - pharmacology ; Potassium Channels - drug effects ; Pyrroles - pharmacology ; trachea ; Trachea (guinea pig) ; Trachea - drug effects ; Trachea - physiology</subject><ispartof>The Japanese Journal of Pharmacology, 1992, Vol.59(1), pp.129-132</ispartof><rights>1992 Elsevier B.V.</rights><rights>The Japanese PharmacologicalSociety</rights><rights>1992 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6299-11417f96d5fea1dbbad4fbe104618167615e65bc0cbb1a204be175a491fc600d3</citedby><cites>FETCH-LOGICAL-c6299-11417f96d5fea1dbbad4fbe104618167615e65bc0cbb1a204be175a491fc600d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5499152$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1507653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Akiko</creatorcontrib><creatorcontrib>Shikada, Ken-ichi</creatorcontrib><creatorcontrib>Tanaka, Sakuya</creatorcontrib><creatorcontrib>Nissan Chemical Ind</creatorcontrib><creatorcontrib>Shiraoka Research Station of Biological Science</creatorcontrib><creatorcontrib>Ltd</creatorcontrib><title>Effects of Anti-Asthma Drugs and Potassium Channel Openers on Neurally-Mediated Contraction of Isolated Guinea Pig Trachea</title><title>Japanese Journal of Pharmacology</title><addtitle>Jpn.J.Pharmacol.</addtitle><description>The effects of anti-asthma drugs, isoproterenol, aminophylline and hydrocortisone, and potassium channel openers on the contraction induced by electrical stimulation or exogenously applied acetylcholine were investigated in isolated guinea pig trachea. Isoproterenol and aminophylline non-selectively inhibited both the contraction evoked by vagus nerve- and that by transmural field-stimulation, but had no effect on the response induced by exogenously applied acetylcholine. Hydrocortisone and potassium channel openers, NIP-121 and cromakalim, preferentially inhibited vagus nerve-mediated response. These results suggest that anti-asthma drugs may have an ability to inhibit neurally-mediated contraction in the guinea pig trachea.</description><subject>Acetylcholine - pharmacology</subject><subject>aminophylline</subject><subject>Aminophylline - administration & dosage</subject><subject>Aminophylline - pharmacology</subject><subject>Animals</subject><subject>Anti-asthma drugs</subject><subject>Benzopyrans - pharmacology</subject><subject>Biological and medical sciences</subject><subject>contraction</subject><subject>Cromakalim</subject><subject>effects on</subject><subject>Electric Stimulation</subject><subject>Guinea Pigs</subject><subject>Histamine and antagonists. Allergy</subject><subject>Hydrocortisone - administration & dosage</subject><subject>Hydrocortisone - pharmacology</subject><subject>isoproterenol</subject><subject>Isoproterenol - administration & dosage</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Neurally-mediated contraction</subject><subject>Oxadiazoles - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - pharmacology</subject><subject>Potassium Channels - drug effects</subject><subject>Pyrroles - pharmacology</subject><subject>trachea</subject><subject>Trachea (guinea pig)</subject><subject>Trachea - drug effects</subject><subject>Trachea - physiology</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEKkvhwh0pB8QBKcWTxE58XG0_qFRoD-VsOc5k15HXCXZSqfx6ZpulXJA4xLHzPn5szSRJ3gM7g5yXX_p-POOS5vJFsoKirLKCM_EyWTGWQ8ZB1q-TNzH2tKwZlCfJCXBWCV6skl8XXYdmiunQpWs_2Wwdp91ep-dh3sZU-za9GyYdo5336WanvUeX3o7oMdAWn37HOWjnHrNv2Fo9YZtuBj8FbSZLKTmv4-Cevl_N1qNO7-w2vad8h_pt8qrTLuK74_s0-XF5cb_5mt3cXl1v1jeZEbmUGUAJVSdFyzvU0DaNbsuuQWClgBpEJYCj4I1hpmlA56ykrOK6lNAZwVhbnCafFu8Yhp8zxkntbTTonPY4zFFVBeQFr4v_giAKUbNaEvh5AU0YYgzYqTHYvQ6PCpg6dERRRxSXND_AH47Wudlj-xddWkD5x2Ouo9GuC9obG58xXkoJPCfscsHIYYkbvKOCqn6Yg6fqKdOJvh9Gp0DKXDHGJQPFQNKTH4Yil0zyuiLR-SLq46S3-HyQDpM1jozjLoLk8HT_ZTgY_sRmp4NCT5py0SC17sFiUNFY9IZuF-iHUu1g_1WN3-U40_w</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Yamamoto, Akiko</creator><creator>Shikada, Ken-ichi</creator><creator>Tanaka, Sakuya</creator><general>The Japanese Pharmacological Society</general><general>Japanese Pharmacological Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Effects of Anti-Asthma Drugs and Potassium Channel Openers on Neurally-Mediated Contraction of Isolated Guinea Pig Trachea</title><author>Yamamoto, Akiko ; Shikada, Ken-ichi ; Tanaka, Sakuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6299-11417f96d5fea1dbbad4fbe104618167615e65bc0cbb1a204be175a491fc600d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acetylcholine - pharmacology</topic><topic>aminophylline</topic><topic>Aminophylline - administration & dosage</topic><topic>Aminophylline - pharmacology</topic><topic>Animals</topic><topic>Anti-asthma drugs</topic><topic>Benzopyrans - pharmacology</topic><topic>Biological and medical sciences</topic><topic>contraction</topic><topic>Cromakalim</topic><topic>effects on</topic><topic>Electric Stimulation</topic><topic>Guinea Pigs</topic><topic>Histamine and antagonists. Allergy</topic><topic>Hydrocortisone - administration & dosage</topic><topic>Hydrocortisone - pharmacology</topic><topic>isoproterenol</topic><topic>Isoproterenol - administration & dosage</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Neurally-mediated contraction</topic><topic>Oxadiazoles - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - pharmacology</topic><topic>Potassium Channels - drug effects</topic><topic>Pyrroles - pharmacology</topic><topic>trachea</topic><topic>Trachea (guinea pig)</topic><topic>Trachea - drug effects</topic><topic>Trachea - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Akiko</creatorcontrib><creatorcontrib>Shikada, Ken-ichi</creatorcontrib><creatorcontrib>Tanaka, Sakuya</creatorcontrib><creatorcontrib>Nissan Chemical Ind</creatorcontrib><creatorcontrib>Shiraoka Research Station of Biological Science</creatorcontrib><creatorcontrib>Ltd</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Akiko</au><au>Shikada, Ken-ichi</au><au>Tanaka, Sakuya</au><aucorp>Nissan Chemical Ind</aucorp><aucorp>Shiraoka Research Station of Biological Science</aucorp><aucorp>Ltd</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Anti-Asthma Drugs and Potassium Channel Openers on Neurally-Mediated Contraction of Isolated Guinea Pig Trachea</atitle><jtitle>Japanese Journal of Pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>1992</date><risdate>1992</risdate><volume>59</volume><issue>1</issue><spage>129</spage><epage>132</epage><pages>129-132</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><coden>JJPAAZ</coden><abstract>The effects of anti-asthma drugs, isoproterenol, aminophylline and hydrocortisone, and potassium channel openers on the contraction induced by electrical stimulation or exogenously applied acetylcholine were investigated in isolated guinea pig trachea. 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| subjects | Acetylcholine - pharmacology aminophylline Aminophylline - administration & dosage Aminophylline - pharmacology Animals Anti-asthma drugs Benzopyrans - pharmacology Biological and medical sciences contraction Cromakalim effects on Electric Stimulation Guinea Pigs Histamine and antagonists. Allergy Hydrocortisone - administration & dosage Hydrocortisone - pharmacology isoproterenol Isoproterenol - administration & dosage Isoproterenol - pharmacology Male Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Neurally-mediated contraction Oxadiazoles - pharmacology Pharmacology. Drug treatments Piperidines - pharmacology Potassium Channels - drug effects Pyrroles - pharmacology trachea Trachea (guinea pig) Trachea - drug effects Trachea - physiology |
| title | Effects of Anti-Asthma Drugs and Potassium Channel Openers on Neurally-Mediated Contraction of Isolated Guinea Pig Trachea |
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