Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial
. Lantz H, Peltonen M, Ågren L, Torgerson JS (Sahlgrenska University Hospital, Göteborg, Sweden). Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial. J Intern Med 2003; 253: 463–471. Objectives. To compare two different very low calorie diet (VLCD)‐bas...
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| description | . Lantz H, Peltonen M, Ågren L, Torgerson JS (Sahlgrenska University Hospital, Göteborg, Sweden). Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial. J Intern Med 2003; 253: 463–471.
Objectives. To compare two different very low calorie diet (VLCD)‐based weight maintenance strategies.
Design and setting. A randomized 2‐year clinical trial performed at the Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Sweden.
Subjects. A total of 334 patients, body mass index (BMI) >30 kg m−2, aged 18–60 years.
Interventions. All the patients started with 16 VLCD weeks. Subjects in the intermittent group were then scheduled to use VLCD for 2 weeks every third month, whilst patients in the on‐demand group were instructed to use VLCD whenever their body weight passed an individualized cut‐off level. Irrespective of the treatment group, all the subjects were recommended a hypocaloric diet during VLCD‐free periods.
Main outcome measures. Changes in body weight, body composition, anthropometric variables and cardiovascular risk factors.
Results. Completers in both groups maintained highly significant weight losses after 2 years: 7.0 ± 11.0 kg (6.2 ± 9.5%) in the intermittent group and 9.1 ± 9.7 kg (7.7 ± 8.1%) in the on‐demand group (P |
| doi_str_mv | 10.1046/j.1365-2796.2003.01131.x |
| format | Article |
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Objectives. To compare two different very low calorie diet (VLCD)‐based weight maintenance strategies.
Design and setting. A randomized 2‐year clinical trial performed at the Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Sweden.
Subjects. A total of 334 patients, body mass index (BMI) >30 kg m−2, aged 18–60 years.
Interventions. All the patients started with 16 VLCD weeks. Subjects in the intermittent group were then scheduled to use VLCD for 2 weeks every third month, whilst patients in the on‐demand group were instructed to use VLCD whenever their body weight passed an individualized cut‐off level. Irrespective of the treatment group, all the subjects were recommended a hypocaloric diet during VLCD‐free periods.
Main outcome measures. Changes in body weight, body composition, anthropometric variables and cardiovascular risk factors.
Results. Completers in both groups maintained highly significant weight losses after 2 years: 7.0 ± 11.0 kg (6.2 ± 9.5%) in the intermittent group and 9.1 ± 9.7 kg (7.7 ± 8.1%) in the on‐demand group (P < 0.001, ns between groups). Male completers in the on‐demand group lost significantly more weight than men in the intermittent group, 14.5 ± 11.0 kg vs. 4.0 ± 10.5 kg, respectively (P < 0.01). Most cardiovascular risk factors improved during the first year, whilst anthropometric measures, insulin, HDL‐ and LDL‐cholesterol were also significantly improved after 2 years of treatment.
Conclusion. Clinically significant weight reductions were achieved after 2 years of VLCD‐based treatment. The structure of VLCD treatment during the maintenance phase did not affect weight loss in the total study population, whilst male subjects might benefit from the VLCD on‐demand strategy.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1046/j.1365-2796.2003.01131.x</identifier><identifier>PMID: 12653876</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Body Composition ; Body Mass Index ; Body Weight ; Caloric Restriction - methods ; Cardiovascular Diseases - etiology ; cardiovascular risk factors ; Confidence Intervals ; Diet, Reducing ; Female ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Obesity ; Obesity - diet therapy ; Patient Dropouts ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Risk Factors ; Secondary Prevention ; Sex Factors ; treatment ; VLCD ; weight maintenance</subject><ispartof>Journal of internal medicine, 2003-04, Vol.253 (4), p.463-471</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Apr 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4731-72d95a58ab243efab2f00b851074ef712eac9e9d4c14e13a98d119cf7e9c3aed3</citedby><cites>FETCH-LOGICAL-c4731-72d95a58ab243efab2f00b851074ef712eac9e9d4c14e13a98d119cf7e9c3aed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2796.2003.01131.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2796.2003.01131.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27915,27916,45565,45566,46400,46824</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14616619$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12653876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lantz, H.</creatorcontrib><creatorcontrib>Peltonen, M.</creatorcontrib><creatorcontrib>Ågren, L.</creatorcontrib><creatorcontrib>Torgerson, J. S.</creatorcontrib><title>Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>. Lantz H, Peltonen M, Ågren L, Torgerson JS (Sahlgrenska University Hospital, Göteborg, Sweden). Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial. J Intern Med 2003; 253: 463–471.
Objectives. To compare two different very low calorie diet (VLCD)‐based weight maintenance strategies.
Design and setting. A randomized 2‐year clinical trial performed at the Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Sweden.
Subjects. A total of 334 patients, body mass index (BMI) >30 kg m−2, aged 18–60 years.
Interventions. All the patients started with 16 VLCD weeks. Subjects in the intermittent group were then scheduled to use VLCD for 2 weeks every third month, whilst patients in the on‐demand group were instructed to use VLCD whenever their body weight passed an individualized cut‐off level. Irrespective of the treatment group, all the subjects were recommended a hypocaloric diet during VLCD‐free periods.
Main outcome measures. Changes in body weight, body composition, anthropometric variables and cardiovascular risk factors.
Results. Completers in both groups maintained highly significant weight losses after 2 years: 7.0 ± 11.0 kg (6.2 ± 9.5%) in the intermittent group and 9.1 ± 9.7 kg (7.7 ± 8.1%) in the on‐demand group (P < 0.001, ns between groups). Male completers in the on‐demand group lost significantly more weight than men in the intermittent group, 14.5 ± 11.0 kg vs. 4.0 ± 10.5 kg, respectively (P < 0.01). Most cardiovascular risk factors improved during the first year, whilst anthropometric measures, insulin, HDL‐ and LDL‐cholesterol were also significantly improved after 2 years of treatment.
Conclusion. Clinically significant weight reductions were achieved after 2 years of VLCD‐based treatment. The structure of VLCD treatment during the maintenance phase did not affect weight loss in the total study population, whilst male subjects might benefit from the VLCD on‐demand strategy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Caloric Restriction - methods</subject><subject>Cardiovascular Diseases - etiology</subject><subject>cardiovascular risk factors</subject><subject>Confidence Intervals</subject><subject>Diet, Reducing</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Obesity</subject><subject>Obesity - diet therapy</subject><subject>Patient Dropouts</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Risk Factors</subject><subject>Secondary Prevention</subject><subject>Sex Factors</subject><subject>treatment</subject><subject>VLCD</subject><subject>weight maintenance</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-KFDEQh4Mo7rj6ChIEvXWbSrqTjgdBFv-MrOxFzyGTVEOG7s6adLs7nnwEn9EnMe0MLnjyVIH6qlJ8P0IosBpYI1_uaxCyrbjSsuaMiZoBCKhv75HN38Z9smG6bSrZcXZGHuW8ZwwEk-whOQMuW9EpuSF-O82YxjDPOM30G6a8ZBqnXz9-ehzt5OmSkcae2rV3oEO8oc4OMQWkPuD8qjRSweIYvqOnvMwd0CbqhjCFAtI5BTs8Jg96O2R8cqrn5Mu7t58vPlSXV--3F28uK9coAZXiXre27eyONwL7UnrGdl0LTDXYK-BonUbtGwcNgrC68wDa9Qq1Exa9OCcvjnuvU_y6YJ7NGLLDYbATxiWb8gkXRVABn_0D7uOSpnKbAV3cKSZUgboj5FLMOWFvrlMYbToYYGaNwezNatusts0ag_kTg7kto09P-5fdiP5u8OS9AM9PgM1FU18cupDvuEaClKAL9_rI3YQBD_99gPl4tf20PsVvLfOlVA</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Lantz, H.</creator><creator>Peltonen, M.</creator><creator>Ågren, L.</creator><creator>Torgerson, J. S.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200304</creationdate><title>Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial</title><author>Lantz, H. ; Peltonen, M. ; Ågren, L. ; Torgerson, J. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4731-72d95a58ab243efab2f00b851074ef712eac9e9d4c14e13a98d119cf7e9c3aed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Caloric Restriction - methods</topic><topic>Cardiovascular Diseases - etiology</topic><topic>cardiovascular risk factors</topic><topic>Confidence Intervals</topic><topic>Diet, Reducing</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Obesity</topic><topic>Obesity - diet therapy</topic><topic>Patient Dropouts</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Risk Factors</topic><topic>Secondary Prevention</topic><topic>Sex Factors</topic><topic>treatment</topic><topic>VLCD</topic><topic>weight maintenance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lantz, H.</creatorcontrib><creatorcontrib>Peltonen, M.</creatorcontrib><creatorcontrib>Ågren, L.</creatorcontrib><creatorcontrib>Torgerson, J. S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lantz, H.</au><au>Peltonen, M.</au><au>Ågren, L.</au><au>Torgerson, J. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2003-04</date><risdate>2003</risdate><volume>253</volume><issue>4</issue><spage>463</spage><epage>471</epage><pages>463-471</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>. Lantz H, Peltonen M, Ågren L, Torgerson JS (Sahlgrenska University Hospital, Göteborg, Sweden). Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial. J Intern Med 2003; 253: 463–471.
Objectives. To compare two different very low calorie diet (VLCD)‐based weight maintenance strategies.
Design and setting. A randomized 2‐year clinical trial performed at the Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Sweden.
Subjects. A total of 334 patients, body mass index (BMI) >30 kg m−2, aged 18–60 years.
Interventions. All the patients started with 16 VLCD weeks. Subjects in the intermittent group were then scheduled to use VLCD for 2 weeks every third month, whilst patients in the on‐demand group were instructed to use VLCD whenever their body weight passed an individualized cut‐off level. Irrespective of the treatment group, all the subjects were recommended a hypocaloric diet during VLCD‐free periods.
Main outcome measures. Changes in body weight, body composition, anthropometric variables and cardiovascular risk factors.
Results. Completers in both groups maintained highly significant weight losses after 2 years: 7.0 ± 11.0 kg (6.2 ± 9.5%) in the intermittent group and 9.1 ± 9.7 kg (7.7 ± 8.1%) in the on‐demand group (P < 0.001, ns between groups). Male completers in the on‐demand group lost significantly more weight than men in the intermittent group, 14.5 ± 11.0 kg vs. 4.0 ± 10.5 kg, respectively (P < 0.01). Most cardiovascular risk factors improved during the first year, whilst anthropometric measures, insulin, HDL‐ and LDL‐cholesterol were also significantly improved after 2 years of treatment.
Conclusion. Clinically significant weight reductions were achieved after 2 years of VLCD‐based treatment. The structure of VLCD treatment during the maintenance phase did not affect weight loss in the total study population, whilst male subjects might benefit from the VLCD on‐demand strategy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12653876</pmid><doi>10.1046/j.1365-2796.2003.01131.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Body Composition Body Mass Index Body Weight Caloric Restriction - methods Cardiovascular Diseases - etiology cardiovascular risk factors Confidence Intervals Diet, Reducing Female Humans Male Medical sciences Metabolic diseases Middle Aged Miscellaneous Obesity Obesity - diet therapy Patient Dropouts Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Risk Factors Secondary Prevention Sex Factors treatment VLCD weight maintenance |
| title | Intermittent versus on‐demand use of a very low calorie diet: a randomized 2‐year clinical trial |
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