Prolonged survival of rat hepatic allografts after total-body irradiation of the donors
The effect of total-body irradiation of the donor on hepatic allograft survival was studied in the rat, with ACI(RT1a) as the donor and LEW(RT1(1)) as the recipient. LEW recipients of ACI liver transplants experienced severe acute rejection, with a mean survival of only 10.2 +/- 0.3 days. The doses...
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| Veröffentlicht in: | Transplantation 1992-08, Vol.54 (2), p.215-218 |
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| container_title | Transplantation |
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| creator | TAKATA, N YAMAGUCHI, Y MORI, K MISUMI, M KATSUMORI, T GOTO, M MAKINO, Y KIKUCHI, N HAMAGUCHI, H OGAWA, M |
| description | The effect of total-body irradiation of the donor on hepatic allograft survival was studied in the rat, with ACI(RT1a) as the donor and LEW(RT1(1)) as the recipient. LEW recipients of ACI liver transplants experienced severe acute rejection, with a mean survival of only 10.2 +/- 0.3 days. The doses of irradiation were 450, 750, and 1000 rads administered 24 hr prior to harvesting or subsequent transplantation. TBI with a dose of 750 rads significantly prolonged the survival of the hepatic allograft to 30.3 +/- 1.7 days, without concomitant immunosuppression. However, neither 450 rads nor 1000 rads of TBI resulted in successful suppression of graft rejection. TBI appeared to have a beneficial effect on hepatic allograft survival and to have no deleterious effect on isograft survival, suggesting a possible modulation of the immunogenicity of the donor organ. Although the cause of this beneficial effect is not clear, TBI with a dose of 750 rads 24 hr prior to organ harvest seems to be optimal to eliminate-antigen presenting cells in the donor organs. |
| doi_str_mv | 10.1097/00007890-199208000-00005 |
| format | Article |
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LEW recipients of ACI liver transplants experienced severe acute rejection, with a mean survival of only 10.2 +/- 0.3 days. The doses of irradiation were 450, 750, and 1000 rads administered 24 hr prior to harvesting or subsequent transplantation. TBI with a dose of 750 rads significantly prolonged the survival of the hepatic allograft to 30.3 +/- 1.7 days, without concomitant immunosuppression. However, neither 450 rads nor 1000 rads of TBI resulted in successful suppression of graft rejection. TBI appeared to have a beneficial effect on hepatic allograft survival and to have no deleterious effect on isograft survival, suggesting a possible modulation of the immunogenicity of the donor organ. Although the cause of this beneficial effect is not clear, TBI with a dose of 750 rads 24 hr prior to organ harvest seems to be optimal to eliminate-antigen presenting cells in the donor organs.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199208000-00005</identifier><identifier>PMID: 1496532</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Dendritic Cells - immunology ; Graft Survival ; Histocompatibility Antigens Class II - analysis ; Liver Transplantation - immunology ; Male ; Medical sciences ; Rats ; Rats, Inbred Strains ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Tissue Donors ; Whole-Body Irradiation</subject><ispartof>Transplantation, 1992-08, Vol.54 (2), p.215-218</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-f4d544775c29d1db0d09f210f0fc2be1e040c70a1c5255e469f773ff9c30ff6c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4369921$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1496532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKATA, N</creatorcontrib><creatorcontrib>YAMAGUCHI, Y</creatorcontrib><creatorcontrib>MORI, K</creatorcontrib><creatorcontrib>MISUMI, M</creatorcontrib><creatorcontrib>KATSUMORI, T</creatorcontrib><creatorcontrib>GOTO, M</creatorcontrib><creatorcontrib>MAKINO, Y</creatorcontrib><creatorcontrib>KIKUCHI, N</creatorcontrib><creatorcontrib>HAMAGUCHI, H</creatorcontrib><creatorcontrib>OGAWA, M</creatorcontrib><title>Prolonged survival of rat hepatic allografts after total-body irradiation of the donors</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>The effect of total-body irradiation of the donor on hepatic allograft survival was studied in the rat, with ACI(RT1a) as the donor and LEW(RT1(1)) as the recipient. LEW recipients of ACI liver transplants experienced severe acute rejection, with a mean survival of only 10.2 +/- 0.3 days. The doses of irradiation were 450, 750, and 1000 rads administered 24 hr prior to harvesting or subsequent transplantation. TBI with a dose of 750 rads significantly prolonged the survival of the hepatic allograft to 30.3 +/- 1.7 days, without concomitant immunosuppression. However, neither 450 rads nor 1000 rads of TBI resulted in successful suppression of graft rejection. TBI appeared to have a beneficial effect on hepatic allograft survival and to have no deleterious effect on isograft survival, suggesting a possible modulation of the immunogenicity of the donor organ. Although the cause of this beneficial effect is not clear, TBI with a dose of 750 rads 24 hr prior to organ harvest seems to be optimal to eliminate-antigen presenting cells in the donor organs.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dendritic Cells - immunology</subject><subject>Graft Survival</subject><subject>Histocompatibility Antigens Class II - analysis</subject><subject>Liver Transplantation - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Tissue Donors</subject><subject>Whole-Body Irradiation</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOIzEQRS00CMLjE5C8GLFrqPKjHS9HiBmQkGABYtly_EgaOe1gd5D4exwSYDlelFW3zq2SLiEU4QJBq0uoT001NKg1g2ntmo0k98gEJRdNW7VfZAIgsEHO1SE5KuVlQ3ClDsgBCt1Kzibk-SGnmIa5d7Ss81v_ZiJNgWYz0oVfmbG31MSY5tmEsdBafKZjGk1sZsm90z5n4_qKpWFjGxeeujSkXE7IfjCx-NPdf0ye_l4_Xt00d_f_bq_-3DVWMBibIJwUQilpmXboZuBAB4YQIFg28-hBgFVg0EompRetDkrxELTlEEJr-TE53-5d5fS69mXsln2xPkYz-LQuneLImODqvyC2HBVyrOB0C9qcSsk-dKvcL01-7xC6TfjdV_jdd_ifkqzWs92N9Wzp3Y9xm3ad_97NTbEmhmwG25dvTPC2LkT-AfmFjHQ</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>TAKATA, N</creator><creator>YAMAGUCHI, Y</creator><creator>MORI, K</creator><creator>MISUMI, M</creator><creator>KATSUMORI, T</creator><creator>GOTO, M</creator><creator>MAKINO, Y</creator><creator>KIKUCHI, N</creator><creator>HAMAGUCHI, H</creator><creator>OGAWA, M</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>Prolonged survival of rat hepatic allografts after total-body irradiation of the donors</title><author>TAKATA, N ; YAMAGUCHI, Y ; MORI, K ; MISUMI, M ; KATSUMORI, T ; GOTO, M ; MAKINO, Y ; KIKUCHI, N ; HAMAGUCHI, H ; OGAWA, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-f4d544775c29d1db0d09f210f0fc2be1e040c70a1c5255e469f773ff9c30ff6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dendritic Cells - immunology</topic><topic>Graft Survival</topic><topic>Histocompatibility Antigens Class II - analysis</topic><topic>Liver Transplantation - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Tissue Donors</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAKATA, N</creatorcontrib><creatorcontrib>YAMAGUCHI, Y</creatorcontrib><creatorcontrib>MORI, K</creatorcontrib><creatorcontrib>MISUMI, M</creatorcontrib><creatorcontrib>KATSUMORI, T</creatorcontrib><creatorcontrib>GOTO, M</creatorcontrib><creatorcontrib>MAKINO, Y</creatorcontrib><creatorcontrib>KIKUCHI, N</creatorcontrib><creatorcontrib>HAMAGUCHI, H</creatorcontrib><creatorcontrib>OGAWA, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKATA, N</au><au>YAMAGUCHI, Y</au><au>MORI, K</au><au>MISUMI, M</au><au>KATSUMORI, T</au><au>GOTO, M</au><au>MAKINO, Y</au><au>KIKUCHI, N</au><au>HAMAGUCHI, H</au><au>OGAWA, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged survival of rat hepatic allografts after total-body irradiation of the donors</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>54</volume><issue>2</issue><spage>215</spage><epage>218</epage><pages>215-218</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>The effect of total-body irradiation of the donor on hepatic allograft survival was studied in the rat, with ACI(RT1a) as the donor and LEW(RT1(1)) as the recipient. LEW recipients of ACI liver transplants experienced severe acute rejection, with a mean survival of only 10.2 +/- 0.3 days. The doses of irradiation were 450, 750, and 1000 rads administered 24 hr prior to harvesting or subsequent transplantation. TBI with a dose of 750 rads significantly prolonged the survival of the hepatic allograft to 30.3 +/- 1.7 days, without concomitant immunosuppression. However, neither 450 rads nor 1000 rads of TBI resulted in successful suppression of graft rejection. TBI appeared to have a beneficial effect on hepatic allograft survival and to have no deleterious effect on isograft survival, suggesting a possible modulation of the immunogenicity of the donor organ. 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| ispartof | Transplantation, 1992-08, Vol.54 (2), p.215-218 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Dendritic Cells - immunology Graft Survival Histocompatibility Antigens Class II - analysis Liver Transplantation - immunology Male Medical sciences Rats Rats, Inbred Strains Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tissue Donors Whole-Body Irradiation |
| title | Prolonged survival of rat hepatic allografts after total-body irradiation of the donors |
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