Interleukin-6/Glycoprotein 130-dependent Pathways Are Protective during Liver Regeneration

After tissue loss the liver has the unique capacity to restore its mass by hepatocyte proliferation. Interleukin-6 (IL6)-deficient mice show a lack in DNA synthesis after partial hepatectomy (PH). To define better the role of IL6 and its family members for liver regeneration after PH, we used condit...

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Veröffentlicht in:	The Journal of biological chemistry 2003-03, Vol.278 (13), p.11281-11288
Hauptverfasser:	Wuestefeld, Torsten, Klein, Christian, Streetz, Konrad L, Betz, Ulrich, Lauber, Jörg, Buer, Jan, Manns, Michael P, Müller, Werner, Trautwein, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - physiology Base Sequence Cytokine Receptor gp130 DNA Primers DNA Replication DNA-Binding Proteins - metabolism Genes, Immediate-Early Hepatectomy Interleukin-6 - genetics Interleukin-6 - physiology Liver - cytology Liver - metabolism Liver Regeneration - physiology Membrane Glycoproteins - physiology Mice Mice, Knockout Oligonucleotide Array Sequence Analysis STAT3 Transcription Factor Trans-Activators - metabolism
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