Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides

Objectives. Increased levels of hypomethylated CpG‐containing DNA in sera from patients with systemic lupus erythematosus (SLE) may contribute to the initiation and/or perpetuation of the disease. This study characterizes the in vitro response of peripheral blood mononuclear cells (PBMC) from SLE pa...

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Veröffentlicht in:	British journal of rheumatology 2003-04, Vol.42 (4), p.563-569
Hauptverfasser:	Zeuner, R. A., Klinman, D. M., Illei, G., Yarboro, C., Ishii, K. J., Gursel, M., Verthelyi, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Cell Division - immunology Cells, Cultured CpG Islands - immunology CpG oligodeoxynucleotide Cytokines - blood Dendritic cells Dendritic Cells - immunology Female Humans Immunoglobulin M - blood Innate immune system Leukocytes, Mononuclear - immunology Lupus Erythematosus, Systemic - immunology Male Medical sciences Middle Aged Monocytes - immunology Oligodeoxyribonucleotides - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis SLE Toll‐like receptor Up-Regulation
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