Identification of detomidine carboxylic acid as the major urinary metabolite of detomidine in the horse

Horse urine was investigated for metabolites by chromatography and mass spectrometry following the oral administration of the large animal analgesic sedative detomidine to two stallions and intravenous administration of [3H]-detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine gluc...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1992, Vol.17 (1), p.13-20
Hauptverfasser:	SALONEN, J. S, VUORILEHTO, L, GILBERT, M, MAYLIN, G. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacokinetics Analgesics - urine Animals Biological and medical sciences Biotransformation Chromatography, Liquid Female Horses - urine Hypnotics and Sedatives - pharmacokinetics Hypnotics and Sedatives - urine Hypnotics. Sedatives Imidazoles - pharmacokinetics Imidazoles - urine Male Mass Spectrometry Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Tritium
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