Role of the α-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system
α‐chemokines, which control the activation and directed migration of leukocytes, participate in the inflammatory processes in host defense response. One of the α‐chemokines, CXCL12 or stromal cell‐derived factor 1 (SDF‐1), not only regulates cell growth and migration of hematopoietic stem cells but...
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| Veröffentlicht in: | Glia 2003-04, Vol.42 (2), p.139-148 |
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| creator | Lazarini, Françoise Tham, To Nam Casanova, Philippe Arenzana-Seisdedos, Fernando Dubois-Dalcq, Monique |
| description | α‐chemokines, which control the activation and directed migration of leukocytes, participate in the inflammatory processes in host defense response. One of the α‐chemokines, CXCL12 or stromal cell‐derived factor 1 (SDF‐1), not only regulates cell growth and migration of hematopoietic stem cells but may also play a central role in brain development as we discuss here. SDF‐1 indeed activates the CXCR4 receptor expressed in a variety of neural cells, and this signaling results in diverse biological effects. It enhances migration and proliferation of cerebellar granule cells, chemoattracts microglia, and stimulates cytokine production and glutamate release by astrocytes. Moreover, it elicits postsynaptic currents in Purkinje cells, triggers migration of cortical neuron progenitors, and produces pain by directly exciting nociceptive neurons. By modulating cell signaling and survival during neuroinflammation, SDF‐1 may also play a role in the pathogenesis of brain tumors, experimental allergic encephalitis, and the nervous system dysfunction associated with acquired immunodeficiency syndrome. GLIA 42:139–148, 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/glia.10139 |
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One of the α‐chemokines, CXCL12 or stromal cell‐derived factor 1 (SDF‐1), not only regulates cell growth and migration of hematopoietic stem cells but may also play a central role in brain development as we discuss here. SDF‐1 indeed activates the CXCR4 receptor expressed in a variety of neural cells, and this signaling results in diverse biological effects. It enhances migration and proliferation of cerebellar granule cells, chemoattracts microglia, and stimulates cytokine production and glutamate release by astrocytes. Moreover, it elicits postsynaptic currents in Purkinje cells, triggers migration of cortical neuron progenitors, and produces pain by directly exciting nociceptive neurons. By modulating cell signaling and survival during neuroinflammation, SDF‐1 may also play a role in the pathogenesis of brain tumors, experimental allergic encephalitis, and the nervous system dysfunction associated with acquired immunodeficiency syndrome. GLIA 42:139–148, 2003. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 0894-1491</identifier><identifier>EISSN: 1098-1136</identifier><identifier>DOI: 10.1002/glia.10139</identifier><identifier>PMID: 12655598</identifier><identifier>CODEN: GLIAEJ</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; brain development ; Cell Differentiation - physiology ; cell migration ; Central Nervous System - embryology ; Central Nervous System - growth & development ; Central Nervous System - metabolism ; Chemokine CXCL12 ; Chemokines, CXC - metabolism ; Chemotaxis - physiology ; CXCR4 ; Development. Senescence. Regeneration. Transplantation ; Encephalitis - metabolism ; Fundamental and applied biological sciences. Psychology ; Humans ; Neuroglia - cytology ; Neuroglia - metabolism ; Neurons - cytology ; Neurons - metabolism ; Receptors, CXCR4 - metabolism ; Signal Transduction - physiology ; Stem Cells - cytology ; Stem Cells - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Glia, 2003-04, Vol.42 (2), p.139-148</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3569-43ff73f29c5e051a266e55aff553cdd4435db757d347ee953740a1cf04bac1d83</citedby><cites>FETCH-LOGICAL-c3569-43ff73f29c5e051a266e55aff553cdd4435db757d347ee953740a1cf04bac1d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fglia.10139$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fglia.10139$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14714714$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12655598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lazarini, Françoise</creatorcontrib><creatorcontrib>Tham, To Nam</creatorcontrib><creatorcontrib>Casanova, Philippe</creatorcontrib><creatorcontrib>Arenzana-Seisdedos, Fernando</creatorcontrib><creatorcontrib>Dubois-Dalcq, Monique</creatorcontrib><title>Role of the α-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system</title><title>Glia</title><addtitle>Glia</addtitle><description>α‐chemokines, which control the activation and directed migration of leukocytes, participate in the inflammatory processes in host defense response. One of the α‐chemokines, CXCL12 or stromal cell‐derived factor 1 (SDF‐1), not only regulates cell growth and migration of hematopoietic stem cells but may also play a central role in brain development as we discuss here. SDF‐1 indeed activates the CXCR4 receptor expressed in a variety of neural cells, and this signaling results in diverse biological effects. It enhances migration and proliferation of cerebellar granule cells, chemoattracts microglia, and stimulates cytokine production and glutamate release by astrocytes. Moreover, it elicits postsynaptic currents in Purkinje cells, triggers migration of cortical neuron progenitors, and produces pain by directly exciting nociceptive neurons. By modulating cell signaling and survival during neuroinflammation, SDF‐1 may also play a role in the pathogenesis of brain tumors, experimental allergic encephalitis, and the nervous system dysfunction associated with acquired immunodeficiency syndrome. GLIA 42:139–148, 2003. © 2003 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>brain development</subject><subject>Cell Differentiation - physiology</subject><subject>cell migration</subject><subject>Central Nervous System - embryology</subject><subject>Central Nervous System - growth & development</subject><subject>Central Nervous System - metabolism</subject><subject>Chemokine CXCL12</subject><subject>Chemokines, CXC - metabolism</subject><subject>Chemotaxis - physiology</subject><subject>CXCR4</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Encephalitis - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Neuroglia - cytology</subject><subject>Neuroglia - metabolism</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0894-1491</issn><issn>1098-1136</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1uEzEQhS0EoqFwwwMg34AAacGzttfry6rQpCiABEVI3FiOPW5N9yfYm0Aeixfhmdj8QO9AsjS29J0znjmEPAT2AhgrX1420Y434PoWmQDTdQHAq9tkwmotChAajsi9nL8yBuND3SVHUFZSSl1PyPJD3yDtAx2ukP76WbgrbPvr2CHNQ-pb21CHTVN4THGNngbrhj7Rpx9fnRXwjMZup_O4xqZfxu6S2s7T1g6rhKOwG9Jo0GFa96tM8yYP2N4nd4JtMj441GPy6ez1xemsmL-fnp-ezAvHZaULwUNQPJTaSWQSbFlVKKUNQUruvBeCS79QUnkuFKKWXAlmwQUmFtaBr_kxebL3Xab-2wrzYNqYt7PYDsffGMUBatDsv2DJRFlp2Do-34Mu9TknDGaZYmvTxgAz2yDMNgizC2KEHx1cV4sW_Q162PwIPD4ANjvbhGQ7F_MNJ9TujBzsue-xwc0_Wprp_PzkT_Nir4njxn_81dh0bSrFlTSf303NF8XeXOi3MzPjvwH_da-M</recordid><startdate>20030415</startdate><enddate>20030415</enddate><creator>Lazarini, Françoise</creator><creator>Tham, To Nam</creator><creator>Casanova, Philippe</creator><creator>Arenzana-Seisdedos, Fernando</creator><creator>Dubois-Dalcq, Monique</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030415</creationdate><title>Role of the α-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system</title><author>Lazarini, Françoise ; Tham, To Nam ; Casanova, Philippe ; Arenzana-Seisdedos, Fernando ; Dubois-Dalcq, Monique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3569-43ff73f29c5e051a266e55aff553cdd4435db757d347ee953740a1cf04bac1d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>brain development</topic><topic>Cell Differentiation - physiology</topic><topic>cell migration</topic><topic>Central Nervous System - embryology</topic><topic>Central Nervous System - growth & development</topic><topic>Central Nervous System - metabolism</topic><topic>Chemokine CXCL12</topic><topic>Chemokines, CXC - metabolism</topic><topic>Chemotaxis - physiology</topic><topic>CXCR4</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Encephalitis - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Neuroglia - cytology</topic><topic>Neuroglia - metabolism</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Receptors, CXCR4 - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lazarini, Françoise</creatorcontrib><creatorcontrib>Tham, To Nam</creatorcontrib><creatorcontrib>Casanova, Philippe</creatorcontrib><creatorcontrib>Arenzana-Seisdedos, Fernando</creatorcontrib><creatorcontrib>Dubois-Dalcq, Monique</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Glia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lazarini, Françoise</au><au>Tham, To Nam</au><au>Casanova, Philippe</au><au>Arenzana-Seisdedos, Fernando</au><au>Dubois-Dalcq, Monique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the α-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system</atitle><jtitle>Glia</jtitle><addtitle>Glia</addtitle><date>2003-04-15</date><risdate>2003</risdate><volume>42</volume><issue>2</issue><spage>139</spage><epage>148</epage><pages>139-148</pages><issn>0894-1491</issn><eissn>1098-1136</eissn><coden>GLIAEJ</coden><abstract>α‐chemokines, which control the activation and directed migration of leukocytes, participate in the inflammatory processes in host defense response. One of the α‐chemokines, CXCL12 or stromal cell‐derived factor 1 (SDF‐1), not only regulates cell growth and migration of hematopoietic stem cells but may also play a central role in brain development as we discuss here. SDF‐1 indeed activates the CXCR4 receptor expressed in a variety of neural cells, and this signaling results in diverse biological effects. It enhances migration and proliferation of cerebellar granule cells, chemoattracts microglia, and stimulates cytokine production and glutamate release by astrocytes. Moreover, it elicits postsynaptic currents in Purkinje cells, triggers migration of cortical neuron progenitors, and produces pain by directly exciting nociceptive neurons. By modulating cell signaling and survival during neuroinflammation, SDF‐1 may also play a role in the pathogenesis of brain tumors, experimental allergic encephalitis, and the nervous system dysfunction associated with acquired immunodeficiency syndrome. GLIA 42:139–148, 2003. © 2003 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12655598</pmid><doi>10.1002/glia.10139</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences brain development Cell Differentiation - physiology cell migration Central Nervous System - embryology Central Nervous System - growth & development Central Nervous System - metabolism Chemokine CXCL12 Chemokines, CXC - metabolism Chemotaxis - physiology CXCR4 Development. Senescence. Regeneration. Transplantation Encephalitis - metabolism Fundamental and applied biological sciences. Psychology Humans Neuroglia - cytology Neuroglia - metabolism Neurons - cytology Neurons - metabolism Receptors, CXCR4 - metabolism Signal Transduction - physiology Stem Cells - cytology Stem Cells - metabolism Vertebrates: nervous system and sense organs |
| title | Role of the α-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system |
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