Stimulation of mitogen-activated protein kinase by oncogenic Ras p21 in Xenopus oocytes. Requirement for Ras p21-GTPase-activating protein interaction

p21ras plays an important role in the control of cell proliferation. The molecular mechanisms implicated are unknown. We report that the injection of oncogenic Lys12 Ras into Xenopus laevis oocytes promoted the activation of mitogen-activated protein kinase (MAP kinase) after a lag of about 90 min....

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Veröffentlicht in:	The Journal of biological chemistry 1992-08, Vol.267 (23), p.16155-16160
Hauptverfasser:	POMERANCE, M, SCHWEIGHOFFER, F, TOCQUE, B, PIERRE, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromatography, Ion Exchange Cloning, Molecular Female Fundamental and applied biological sciences. Psychology Genes, ras GTPase-Activating Proteins Kinetics mitogens Molecular and cellular biology oocytes Oocytes - metabolism Polymerase Chain Reaction protein kinase Protein Kinases - isolation & purification Protein Kinases - metabolism Proteins - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism ras GTPase-Activating Proteins Ras p21 Recombinant Proteins - metabolism Ribosomal Protein S6 Kinases stimulation Xenopus Xenopus laevis
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