Inhibition of bacterial IF2 binding to fMet-tRNA (fMet) by aminoglycosides

Screening for inhibitors of bacterial protein synthesis Initiation Factor 2 (IF2) binding to N-formyl-Methionyl-transfer RNA (fMet-tRNA (fMet)) identified a series of aminoglycosides, that included amikacin and kanamycin A1, as inhibitors of this interaction. Subsequent testing revealed that aminogl...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-03, Vol.13 (6), p.993-996
Hauptverfasser:	Evans, J.M, Turner, B.A, Bowen, S, Ho, A.M, Sarver, R.W, Benson, E, Parker, C.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Bacteria - metabolism Biological and medical sciences Carbohydrate Sequence Escherichia coli - drug effects Escherichia coli - metabolism Kanamycin - pharmacology Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Prokaryotic Initiation Factor-2 - drug effects Prokaryotic Initiation Factor-2 - metabolism Protein Denaturation RNA, Transfer, Met - drug effects RNA, Transfer, Met - metabolism
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