Structural Genomics of Membrane Proteins

A program on the structural genomics of membrane proteins has started at the BIRC, AIST, involving other academic institutions and industrial companies. Emphasis is being put on the development of techniques for the structural determination of membrane proteins of biological importance and ligand−re...

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Veröffentlicht in:	Accounts of chemical research 2003-03, Vol.36 (3), p.199-206
Hauptverfasser:	Kyogoku, Yoshimasa, Fujiyoshi, Yoshinori, Shimada, Ichio, Nakamura, Haruki, Tsukihara, Tomitake, Akutsu, Hideo, Odahara, Takayuki, Okada, Tetsuji, Nomura, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriorhodopsins - chemistry Crystallography, X-Ray Genomics - instrumentation Genomics - methods Human Genome Project Membrane Proteins - chemistry Models, Molecular Protein Conformation
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container_title	Accounts of chemical research
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creator	Kyogoku, Yoshimasa Fujiyoshi, Yoshinori Shimada, Ichio Nakamura, Haruki Tsukihara, Tomitake Akutsu, Hideo Odahara, Takayuki Okada, Tetsuji Nomura, Nobuo
description	A program on the structural genomics of membrane proteins has started at the BIRC, AIST, involving other academic institutions and industrial companies. Emphasis is being put on the development of techniques for the structural determination of membrane proteins of biological importance and ligand−receptor interactions by means of electron microscopy, X-ray diffraction, NMR, and computer simulation. Most efforts at the present stage, however, are being directed to finding suitable expression and purification systems and crystallization conditions for such proteins. The program is expected to be linked with the human full-length cDNA project and should lead to medical and industrial uses.
doi_str_mv	10.1021/ar0101279
format	Article
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subjects	Bacteriorhodopsins - chemistry Crystallography, X-Ray Genomics - instrumentation Genomics - methods Human Genome Project Membrane Proteins - chemistry Models, Molecular Protein Conformation
title	Structural Genomics of Membrane Proteins
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